Detection of SARS-CoV-2 antibodies in febrile patients from an endemic region of dengue and chikungunya in Peru
Average rating
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Star rating
Your vote was cast
Thank you for your feedback
Thank you for your feedback
Authors
Tarazona-Castro, YordiTroyes-Rivera, Lucinda
Martins-Luna, Johanna
Cabellos-Altamirano, Felipe
Aguilar-Luis, Miguel Angel
Carrillo-Ng, Hugo
Del Valle, Luis J.
Kym, Sungmin
Miranda-Maravi, Sebastian
Silva-Caso, Wilmer
Levy-Blitchtein, Saul
del Valle-Mendoza, Juana
Issue Date
2022-04-01Keywords
AntibodiesArthralgia
Chikungunya fever
Chikungunya virus
Coinfection
COVID-19
Cross-Sectional studies
Dengue
Fever
Humans
Immunoglobulin M
Peru
SARS-CoV-2
Zika virus infection
Metadata
Show full item recordPublisher
Public Library of ScienceJournal
PLoS ONEDOI
10.1371/journal.pone.0265820Abstract
Introduction The rapid expansion of the novel SARS-CoV-2 virus has raised serious public health concerns due to the possibility of misdiagnosis in regions where arboviral diseases are endemic. We performed the first study in northern Peru to describe the detection of SARSCoV-2 IgM antibodies in febrile patients with a suspected diagnosis of dengue and chikungunya fever. Materials and methods A consecutive cross-sectional study was performed in febrile patients attending primary healthcare centers from April 2020 through March 2021. Patients enrolled underwent serum sample collection for the molecular and serological detection of DENV and CHIKV. Also, serological detection of IgM antibodies against SARS-CoV-2 was performed. Results 464 patients were included during the study period, of which (40.51%) were positive for one pathogen, meanwhile (6.90%) presented co-infections between 2 or more pathogens. The majority of patients with monoinfections were positive for SARS-CoV-2 IgM with (73.40%), followed by DENV 18.09% and CHIKV (8.51%). The most frequent co-infection was DENV + SARS-CoV-2 with (65.63%), followed by DENV + CHIKV and DENV + CHIKV + SARSCoV-2, both with (12.50%). The presence of polyarthralgias in hands (43.75%, p<0.01) and feet (31.25%, p = 0.05) were more frequently reported in patients with CHIKV monoinfection. Also, conjunctivitis was more common in patients positive for SARS-CoV-2 IgM (11.45%, p<0.01). The rest of the symptoms were similar among all the study groups. Conclusion SARS-CoV-2 IgM antibodies were frequently detected in acute sera from febrile patients with a clinical suspicion of arboviral disease. The presence of polyarthralgias in hands and feet may be suggestive of CHIKV infection. These results reaffirm the need to consider SARS-CoV-2 infection as a main differential diagnosis of acute febrile illness in arboviruses endemic areas, as well as to consider co-infections between these pathogens. Copyright:Type
info:eu-repo/semantics/articleRights
info:eu-repo/semantics/openAccessAttribution-NonCommercial-ShareAlike 4.0 International
Language
engEISSN
19326203ae974a485f413a2113503eed53cd6c53
10.1371/journal.pone.0265820
Scopus Count
Collections
The following license files are associated with this item:
- Creative Commons