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dc.contributor.authordel Valle-Mendoza, Juana
dc.contributor.authorTarazona-Castro, Yordi
dc.contributor.authorMerino-Luna, Alfredo
dc.contributor.authorCarrillo-Ng, Hugo
dc.contributor.authorKym, Sungmin
dc.contributor.authorAguilar-luis, Miguel Angel
dc.contributor.authorDel Valle, Luis J.
dc.contributor.authorAquino-Ortega, Ronald
dc.contributor.authorMartins-Luna, Johanna
dc.contributor.authorPeña-Tuesta, Isaac
dc.contributor.authorSilva-Caso, Wilmer
dc.date.accessioned2022-03-04T03:46:27Z
dc.date.available2022-03-04T03:46:27Z
dc.date.issued2022-12-01
dc.identifier.doi10.1186/s12879-022-07079-x
dc.identifier.urihttp://hdl.handle.net/10757/659236
dc.description.abstractBackground: At the end of 2019, a novel coronavirus denominated SARS-CoV-2 rapidly spread through the world causing the pandemic coronavirus disease known as COVID-19. The difference in the inflammatory response against SARS-CoV-2 infection among people living at different altitudes is a variable not yet studied. Methods: A descriptive cross-sectional study was performed in two Peruvian cities at different altitudes for comparison: Lima and Huaraz. Five important proinflammatory cytokines were measured including: IL-6, IL-2, IL-10, IFN-γ and TNF-α using ELISA assays. Results: A total of 35 COVID-19 patients and 10 healthy subjects were recruited from each study site. The mean levels of IL-6 (p < 0.03) and TNF-α (p < 0.01) were significantly different among the study groups. In the case of IL-6, patients from Lima had a mean level of 16.2 pg/ml (healthy) and 48.3 pg/ml (COVID-19), meanwhile, patients from Huaraz had levels of 67.3 pg/ml (healthy) and 97.9 pg/ml (COVID-19). Regarding TNF-α, patients from Lima had a mean level of 25.9 pg/ml (healthy) and 61.6 pg/ml (COVID-19), meanwhile, patients from Huaraz had levels of 89.0 pg/ml (healthy) and 120.6 pg/ml (COVID-19). The levels of IL-2, IL-10 and IFN-γ were not significantly different in the study groups. Conclusion: Patients with COVID-19 residing at high-altitude tend to have higher levels of inflammatory cytokines compared to patients living at sea level, particularly IL-6 and TNF-α. A better understanding of the inflammatory response in different populations can contribute to the implementation of therapeutic and preventive approaches. Further studies evaluating more patients, a greater variety of cytokines and their clinical impact are required.es_PE
dc.description.sponsorshipNational Research Foundation of Koreaes_PE
dc.formatapplication/pdfes_PE
dc.language.isoenges_PE
dc.publisherBioMed Central Ltdes_PE
dc.relation.urlhttps://bmcinfectdis.biomedcentral.com/articles/10.1186/s12879-022-07079-xes_PE
dc.rightsinfo:eu-repo/semantics/openAccesses_PE
dc.rightsAttribution-NonCommercial-ShareAlike 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.sourceUniversidad Peruana de Ciencias Aplicadas (UPC)es_PE
dc.sourceRepositorio Academico - UPCes_PE
dc.subjectCOVID-19es_PE
dc.subjectCytokineses_PE
dc.subjectDifferent altitudeses_PE
dc.subjectPerues_PE
dc.subjectSARS-CoV-2es_PE
dc.titleComparison of cytokines levels among COVID-19 patients living at sea level and high altitudees_PE
dc.typeinfo:eu-repo/semantics/articlees_PE
dc.identifier.eissn14712334
dc.identifier.journalBMC Infectious Diseaseses_PE
dc.description.peerreviewRevisión por pareses_PE
dc.identifier.eid2-s2.0-85123875878
dc.identifier.scopusidSCOPUS_ID:85123875878
dc.source.journaltitleBMC Infectious Diseases
dc.source.volume22
dc.source.issue1
refterms.dateFOA2022-03-04T03:46:28Z
dc.identifier.isni0000 0001 2196 144X


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