Comparison of cytokines levels among COVID-19 patients living at sea level and high altitude
dc.contributor.author | del Valle-Mendoza, Juana | |
dc.contributor.author | Tarazona-Castro, Yordi | |
dc.contributor.author | Merino-Luna, Alfredo | |
dc.contributor.author | Carrillo-Ng, Hugo | |
dc.contributor.author | Kym, Sungmin | |
dc.contributor.author | Aguilar-luis, Miguel Angel | |
dc.contributor.author | Del Valle, Luis J. | |
dc.contributor.author | Aquino-Ortega, Ronald | |
dc.contributor.author | Martins-Luna, Johanna | |
dc.contributor.author | Peña-Tuesta, Isaac | |
dc.contributor.author | Silva-Caso, Wilmer | |
dc.date.accessioned | 2022-03-04T03:46:27Z | |
dc.date.available | 2022-03-04T03:46:27Z | |
dc.date.issued | 2022-12-01 | |
dc.identifier.doi | 10.1186/s12879-022-07079-x | |
dc.identifier.uri | http://hdl.handle.net/10757/659236 | |
dc.description.abstract | Background: At the end of 2019, a novel coronavirus denominated SARS-CoV-2 rapidly spread through the world causing the pandemic coronavirus disease known as COVID-19. The difference in the inflammatory response against SARS-CoV-2 infection among people living at different altitudes is a variable not yet studied. Methods: A descriptive cross-sectional study was performed in two Peruvian cities at different altitudes for comparison: Lima and Huaraz. Five important proinflammatory cytokines were measured including: IL-6, IL-2, IL-10, IFN-γ and TNF-α using ELISA assays. Results: A total of 35 COVID-19 patients and 10 healthy subjects were recruited from each study site. The mean levels of IL-6 (p < 0.03) and TNF-α (p < 0.01) were significantly different among the study groups. In the case of IL-6, patients from Lima had a mean level of 16.2 pg/ml (healthy) and 48.3 pg/ml (COVID-19), meanwhile, patients from Huaraz had levels of 67.3 pg/ml (healthy) and 97.9 pg/ml (COVID-19). Regarding TNF-α, patients from Lima had a mean level of 25.9 pg/ml (healthy) and 61.6 pg/ml (COVID-19), meanwhile, patients from Huaraz had levels of 89.0 pg/ml (healthy) and 120.6 pg/ml (COVID-19). The levels of IL-2, IL-10 and IFN-γ were not significantly different in the study groups. Conclusion: Patients with COVID-19 residing at high-altitude tend to have higher levels of inflammatory cytokines compared to patients living at sea level, particularly IL-6 and TNF-α. A better understanding of the inflammatory response in different populations can contribute to the implementation of therapeutic and preventive approaches. Further studies evaluating more patients, a greater variety of cytokines and their clinical impact are required. | es_PE |
dc.description.sponsorship | National Research Foundation of Korea | es_PE |
dc.format | application/pdf | es_PE |
dc.language.iso | eng | es_PE |
dc.publisher | BioMed Central Ltd | es_PE |
dc.relation.url | https://bmcinfectdis.biomedcentral.com/articles/10.1186/s12879-022-07079-x | es_PE |
dc.rights | info:eu-repo/semantics/openAccess | es_PE |
dc.rights | Attribution-NonCommercial-ShareAlike 4.0 International | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-sa/4.0/ | * |
dc.source | Universidad Peruana de Ciencias Aplicadas (UPC) | es_PE |
dc.source | Repositorio Academico - UPC | es_PE |
dc.subject | COVID-19 | es_PE |
dc.subject | Cytokines | es_PE |
dc.subject | Different altitudes | es_PE |
dc.subject | Peru | es_PE |
dc.subject | SARS-CoV-2 | es_PE |
dc.title | Comparison of cytokines levels among COVID-19 patients living at sea level and high altitude | es_PE |
dc.type | info:eu-repo/semantics/article | es_PE |
dc.identifier.eissn | 14712334 | |
dc.identifier.journal | BMC Infectious Diseases | es_PE |
dc.description.peerreview | Revisión por pares | es_PE |
dc.identifier.eid | 2-s2.0-85123875878 | |
dc.identifier.scopusid | SCOPUS_ID:85123875878 | |
dc.source.journaltitle | BMC Infectious Diseases | |
dc.source.volume | 22 | |
dc.source.issue | 1 | |
refterms.dateFOA | 2022-03-04T03:46:28Z | |
dc.identifier.isni | 0000 0001 2196 144X |
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