Comparison of cytokines levels among COVID-19 patients living at sea level and high altitude
Average rating
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Star rating
Your vote was cast
Thank you for your feedback
Thank you for your feedback
Autor
del Valle-Mendoza, JuanaTarazona-Castro, Yordi
Merino-Luna, Alfredo
Carrillo-Ng, Hugo
Kym, Sungmin
Aguilar-luis, Miguel Angel
Del Valle, Luis J.
Aquino-Ortega, Ronald
Martins-Luna, Johanna
Peña-Tuesta, Isaac
Silva-Caso, Wilmer
Fecha de publicación
2022-12-01
Metadatos
Mostrar el registro completo del ítemEditorial
BioMed Central LtdJournal
BMC Infectious DiseasesDOI
10.1186/s12879-022-07079-xEnlaces adicionales
https://bmcinfectdis.biomedcentral.com/articles/10.1186/s12879-022-07079-xResumen
Background: At the end of 2019, a novel coronavirus denominated SARS-CoV-2 rapidly spread through the world causing the pandemic coronavirus disease known as COVID-19. The difference in the inflammatory response against SARS-CoV-2 infection among people living at different altitudes is a variable not yet studied. Methods: A descriptive cross-sectional study was performed in two Peruvian cities at different altitudes for comparison: Lima and Huaraz. Five important proinflammatory cytokines were measured including: IL-6, IL-2, IL-10, IFN-γ and TNF-α using ELISA assays. Results: A total of 35 COVID-19 patients and 10 healthy subjects were recruited from each study site. The mean levels of IL-6 (p < 0.03) and TNF-α (p < 0.01) were significantly different among the study groups. In the case of IL-6, patients from Lima had a mean level of 16.2 pg/ml (healthy) and 48.3 pg/ml (COVID-19), meanwhile, patients from Huaraz had levels of 67.3 pg/ml (healthy) and 97.9 pg/ml (COVID-19). Regarding TNF-α, patients from Lima had a mean level of 25.9 pg/ml (healthy) and 61.6 pg/ml (COVID-19), meanwhile, patients from Huaraz had levels of 89.0 pg/ml (healthy) and 120.6 pg/ml (COVID-19). The levels of IL-2, IL-10 and IFN-γ were not significantly different in the study groups. Conclusion: Patients with COVID-19 residing at high-altitude tend to have higher levels of inflammatory cytokines compared to patients living at sea level, particularly IL-6 and TNF-α. A better understanding of the inflammatory response in different populations can contribute to the implementation of therapeutic and preventive approaches. Further studies evaluating more patients, a greater variety of cytokines and their clinical impact are required.Tipo
info:eu-repo/semantics/articleDerechos
info:eu-repo/semantics/openAccessAttribution-NonCommercial-ShareAlike 4.0 International
Idioma
engEISSN
14712334Patrocinadores
National Research Foundation of Koreaae974a485f413a2113503eed53cd6c53
10.1186/s12879-022-07079-x
Scopus Count
Colecciones
El ítem tiene asociados los siguientes ficheros de licencia:
- Creative Commons
Excepto si se señala otra cosa, la licencia del ítem se describe como info:eu-repo/semantics/openAccess