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dc.contributor.authorDel Valle-Mendoza, Juana
dc.contributor.authordel Valle-Vargas, Cristina
dc.contributor.authorAquino-Ortega, Ronald
dc.contributor.authorDel Valle, Luis J.
dc.contributor.authorCieza-Mora, Erico
dc.contributor.authorSilva-Caso, Wilmer
dc.contributor.authorBazán-Mayra, Jorge
dc.contributor.authorZavaleta-Gavidia, Victor
dc.contributor.authorAguilar-Luis, Miguel Angel
dc.contributor.authorCornejo-Pacherres, Hernán
dc.contributor.authorMartins-Luna, Johanna
dc.contributor.authorCornejo-Tapia, Angela
dc.date.accessioned2022-01-05T14:12:50Z
dc.date.available2022-01-05T14:12:50Z
dc.date.issued2021-02-01
dc.identifier.issn20083289
dc.identifier.urihttp://hdl.handle.net/10757/658456
dc.description.abstractBackground and Objectives: Pertussis is an infectious disease caused by the Gram-negative bacterium Bordetella pertussis. In Peru, actual public health programs indicate that vaccination against B. pertussis must be mandatory and generalized, be-sides all detected cases must be reported. The objective of this study was to determine the prevalence of B. pertussis among children under five years of age with a presumptive diagnosis of whopping cough in Cajamarca, a region located in northern Peru. Materials and Methods: The population of this cross-sectional study were children under 5 years old hospitalized as presumptive cases of pertussis during December 2017 to December 2018. The nasopharyngeal samples were analyzed by real-time PCR for the detection of B. pertussis. Results: B. pertussis was identified as PCR + in 42.3% of our sample (33/78). The clinical presentation that was observed most frequently includes paroxysmal coughing (97%), difficulty breathing (69.7%), cyanosis (72.7%) and post-tussive em-esis (60.6%). Additionally, pneumonia was the most observed complication (33.3%). Four of the patients with PCR+ for B. pertussis presented only lymphocytosis, five only leukocytosis, two patients with decreased leukocytosis and lymphocytes and only one patient with leukopenia and relative lymphocytosis. There was a percentage of 84.8% of unvaccinated children in the PCR+ group. Finally, the mother was the most frequent symptom carrier (18.2%). Conclusion: In conclusion, in the studied population there is a high rate of PCR+ cases for B. pertussis. Laboratory values may show leukopenia or lymphopenia in patients with pertussis. It is necessary to use appropriate laboratory diagnostic tests in all infants with respiratory symptoms for B. pertussis. Since, the clinical diagnosis overestimates the diagnosis of pertussis.es_PE
dc.formatapplication/pdfes_PE
dc.language.isoenges_PE
dc.publisherTehran University of Medical Scienceses_PE
dc.relation.urlhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8043828/es_PE
dc.rightsinfo:eu-repo/semantics/openAccesses_PE
dc.rightsAttribution-NonCommercial-ShareAlike 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.sourceUniversidad Peruana de Ciencias Aplicadas (UPC)es_PE
dc.sourceRepositorio Academico - UPCes_PE
dc.subjectBordetella pertussises_PE
dc.subjectPerues_PE
dc.subjectReal-time polymerase chain reactiones_PE
dc.subjectWhooping coughes_PE
dc.titleClinical characteristics and molecular detection of bordetella pertussis in hospitalized children with a clinical diagnosis of whooping cough in Perues_PE
dc.typeinfo:eu-repo/semantics/articlees_PE
dc.identifier.eissn20084447
dc.identifier.journalIranian Journal of Microbiologyes_PE
dc.description.peerreviewRevisión por pareses_PE
dc.identifier.eid2-s2.0-85101618279
dc.identifier.scopusidSCOPUS_ID:85101618279
dc.source.journaltitleIranian Journal of Microbiology
dc.source.volume13
dc.source.issue1
dc.source.beginpage23
dc.source.endpage30
refterms.dateFOA2022-01-05T14:12:51Z
dc.identifier.isni0000 0001 2196 144X


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