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dc.contributor.authorSadanandan, Nadia
dc.contributor.authorShear, Alex
dc.contributor.authorBrooks, Beverly
dc.contributor.authorSaft, Madeline
dc.contributor.authorCabantan, Dorothy Anne Galang
dc.contributor.authorKingsbury, Chase
dc.contributor.authorZhang, Henry
dc.contributor.authorAnthony, Stefan
dc.contributor.authorWang, Zhen Jie
dc.contributor.authorSalazar, Felipe Esparza
dc.contributor.authorLezama Toledo, Alma R.
dc.contributor.authorRivera Monroy, Germán
dc.contributor.authorVega Gonzales-Portillo, Joaquin
dc.contributor.authorMoscatello, Alexa
dc.contributor.authorLee, Jea Young
dc.contributor.authorBorlongan, Cesario V.
dc.date.accessioned2022-01-04T15:36:41Z
dc.date.available2022-01-04T15:36:41Z
dc.date.issued2021-11-24
dc.identifier.issn16625099
dc.identifier.doi10.3389/fnmol.2021.749716
dc.identifier.urihttp://hdl.handle.net/10757/658440
dc.description.abstractStem cell therapy may present an effective treatment for metastatic brain cancer and glioblastoma. Here we posit the critical role of a leaky blood-brain barrier (BBB) as a key element for the development of brain metastases, specifically melanoma. By reviewing the immunological and inflammatory responses associated with BBB damage secondary to tumoral activity, we identify the involvement of this pathological process in the growth and formation of metastatic brain cancers. Likewise, we evaluate the hypothesis of regenerating impaired endothelial cells of the BBB and alleviating the damaged neurovascular unit to attenuate brain metastasis, using the endothelial progenitor cell (EPC) phenotype of bone marrow-derived mesenchymal stem cells. Specifically, there is a need to evaluate the efficacy for stem cell therapy to repair disruptions in the BBB and reduce inflammation in the brain, thereby causing attenuation of metastatic brain cancers. To establish the viability of stem cell therapy for the prevention and treatment of metastatic brain tumors, it is crucial to demonstrate BBB repair through augmentation of vasculogenesis and angiogenesis. BBB disruption is strongly linked to metastatic melanoma, worsens neuroinflammation during metastasis, and negatively influences the prognosis of metastatic brain cancer. Using stem cell therapy to interrupt inflammation secondary to this leaky BBB represents a paradigm-shifting approach for brain cancer treatment. In this review article, we critically assess the advantages and disadvantages of using stem cell therapy for brain metastases and glioblastoma.es_PE
dc.description.sponsorshipNational Institutes of Healthes_PE
dc.formatapplication/pdfes_PE
dc.language.isoenges_PE
dc.publisherFrontiers Media S.A.es_PE
dc.relation.urlhttps://www.frontiersin.org/articles/10.3389/fnmol.2021.749716/fulles_PE
dc.rightsinfo:eu-repo/semantics/openAccesses_PE
dc.rightsAttribution-NonCommercial-ShareAlike 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.sourceUniversidad Peruana de Ciencias Aplicadas (UPC)es_PE
dc.sourceRepositorio Academico - UPCes_PE
dc.subjectblood brain barrieres_PE
dc.subjectbone marrow derived mesenchymal stem celles_PE
dc.subjectbrain metastaseses_PE
dc.subjectendothelial progenitor celles_PE
dc.subjectmelanomaes_PE
dc.subjectneuroinflammationes_PE
dc.subjectstem cell therapyes_PE
dc.titleTreating Metastatic Brain Cancers With Stem Cellses_PE
dc.typeinfo:eu-repo/semantics/articlees_PE
dc.identifier.journalFrontiers in Molecular Neurosciencees_PE
dc.description.peerreviewRevisión por pareses_PE
dc.identifier.eid2-s2.0-85120911475
dc.identifier.scopusidSCOPUS_ID:85120911475
dc.source.journaltitleFrontiers in Molecular Neuroscience
dc.source.volume14
refterms.dateFOA2022-01-04T15:36:42Z
dc.identifier.isni0000 0001 2196 144X


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