Clinical characteristics and molecular detection of in hospitalized children with a clinical diagnosis of whooping cough in Peru.
Average rating
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Star rating
Your vote was cast
Thank you for your feedback
Thank you for your feedback
Authors
Del Valle-Mendoza, Juanadel Valle-Vargas, Cristina
Aquino-Ortega, Ronald
Del Valle, Luis J
Cieza-Mora, Erico
Silva-Caso, Wilmer
Bazán-Mayra, Jorge
Zavaleta-Gavidia, Victor
Aguilar-Luis, Miguel Angel
Cornejo-Pacherres, Hernán
Martins-Luna, Johanna
Cornejo-Tapia, Angela
Issue Date
2021-01
Metadata
Show full item recordPublisher
Tehran University of Medical SciencesJournal
Iranian journal of microbiologyDOI
10.18502/ijm.v13i1.5488PubMed ID
33889359Additional Links
https://pubmed.ncbi.nlm.nih.gov/33889359/Abstract
Pertussis is an infectious disease caused by the Gram-negative bacterium Bordetella pertussis. In Peru, actual public health programs indicate that vaccination against B. pertussis must be mandatory and generalized, besides all detected cases must be reported. The objective of this study was to determine the prevalence of B. pertussis among children under five years of age with a presumptive diagnosis of whopping cough in Cajamarca, a region located in northern Peru.Background and Objectives: Pertussis is an infectious disease caused by the Gram-negative bacterium Bordetella pertussis. In Peru, actual public health programs indicate that vaccination against B. pertussis must be mandatory and generalized, be-sides all detected cases must be reported. The objective of this study was to determine the prevalence of B. pertussis among children under five years of age with a presumptive diagnosis of whopping cough in Cajamarca, a region located in northern Peru. Materials and Methods: The population of this cross-sectional study were children under 5 years old hospitalized as presumptive cases of pertussis during December 2017 to December 2018. The nasopharyngeal samples were analyzed by real-time PCR for the detection of B. pertussis. Results: B. pertussis was identified as PCR + in 42.3% of our sample (33/78). The clinical presentation that was observed most frequently includes paroxysmal coughing (97%), difficulty breathing (69.7%), cyanosis (72.7%) and post-tussive em-esis (60.6%). Additionally, pneumonia was the most observed complication (33.3%). Four of the patients with PCR+ for B. pertussis presented only lymphocytosis, five only leukocytosis, two patients with decreased leukocytosis and lymphocytes and only one patient with leukopenia and relative lymphocytosis. There was a percentage of 84.8% of unvaccinated children in the PCR+ group. Finally, the mother was the most frequent symptom carrier (18.2%). Conclusion: In conclusion, in the studied population there is a high rate of PCR+ cases for B. pertussis. Laboratory values may show leukopenia or lymphopenia in patients with pertussis. It is necessary to use appropriate laboratory diagnostic tests in all infants with respiratory symptoms for B. pertussis. Since, the clinical diagnosis overestimates the diagnosis of pertussis.
Type
info:eu-repo/semantics/articleRights
info:eu-repo/semantics/openAccessAttribution-NonCommercial-ShareAlike 4.0 International
Language
engISSN
2008-3289ae974a485f413a2113503eed53cd6c53
10.18502/ijm.v13i1.5488
Scopus Count
Collections
The following license files are associated with this item:
- Creative Commons
Related articles
- Bordetella pertussis diagnosis in children under five years of age in the Regional Hospital of Cajamarca, Northern Peru.
- Authors: Del Valle-Mendoza J, Casabona-Oré V, Petrozzi-Helasvuo V, Cornejo-Tapia A, Weilg P, Pons MJ, Cieza-Mora E, Bazán-Mayra J, Cornejo-Pacherres H, Ruiz J
- Issue date: 2015 Nov 30
- Detection of Bordetella pertussis using a PCR test in infants younger than one year old hospitalized with whooping cough in five Peruvian hospitals.
- Authors: Castillo ME, Bada C, Del Aguila O, Petrozzi-Helasvuo V, Casabona-Ore V, Reyes I, Del Valle-Mendoza J
- Issue date: 2015 Dec
- Bordetella pertussis in children hospitalized with a respiratory infection: clinical characteristics and pathogen detection in household contacts.
- Authors: Del Valle-Mendoza J, Silva-Caso W, Aguilar-Luis MA, Del Valle-Vargas C, Cieza-Mora E, Martins-Luna J, Aquino-Ortega R, Silva-Vásquez A, Bazán-Mayra J, Weilg P
- Issue date: 2018 May 18
- Real-Time Polymerase Chain Reaction-Based Detection of Bordetella pertussis in Mexican Infants and Their Contacts: A 3-Year Multicenter Study.
- Authors: Aquino-Andrade A, Martínez-Leyva G, Mérida-Vieyra J, Saltigeral P, Lara A, Domínguez W, García de la Puente S, De Colsa A
- Issue date: 2017 Sep
- [Clinical analysis of 247 children with whooping cough and the risk factors of severe cases].
- Authors: Hu Y, Liu Q
- Issue date: 2015 Sep