Show simple item record

dc.contributor.authorBlair, Cheríe S.
dc.contributor.authorLake, Jordan E.
dc.contributor.authorPassaro, Ryan C.
dc.contributor.authorChavez-Gomez, Susan
dc.contributor.authorSegura, Eddy R.
dc.contributor.authorElliott, Julie
dc.contributor.authorFulcher, Jennifer A.
dc.contributor.authorShoptaw, Steven
dc.contributor.authorCabello, Robinson
dc.contributor.authorClark, Jesse L.
dc.date.accessioned2021-05-03T13:48:00Z
dc.date.available2021-05-03T13:48:00Z
dc.date.issued2021-04-15
dc.identifier.doi10.1097/QAI.0000000000002601
dc.identifier.urihttp://hdl.handle.net/10757/655812
dc.descriptionEl texto completo de este trabajo no está disponible en el Repositorio Académico UPC por restricciones de la casa editorial donde ha sido publicado.en_US
dc.description.abstractOBJECTIVE: Determine the impact of HIV-1 seroconversion on inflammatory cytokines in the rectal mucosa. SETTING: Secondary analysis of data from men who have sex with men and transgender women who participated in a HIV prevention trial Lima, Peru. METHODS: From July to December 2017, 605 men who have sex with men and transgender women were screened for rectal gonorrhea/chlamydia (GC/CT). Fifty GC/CT-positive cases were randomly selected and matched with 52 GC/CT-negative controls by age and number of receptive anal intercourse partners in the last month. All participants were HIV-negative at baseline and those with GC/CT at baseline and/or follow-up received appropriate antibiotic therapy. Participants underwent sponge collection of rectal secretions for the measurement of inflammatory cytokines (IL-1β, IL-6, IL-8, and TNF-α) and were screened for rectal GC/CT and HIV at baseline, 3 months, and 6 months. Wilcoxon rank-sum tests compared inflammatory cytokine levels between participants diagnosed with HIV during follow-up and persons who remained HIV-negative. RESULTS: Eight participants were diagnosed with HIV at the 3-month (n = 6) or 6-month (n = 2) visit. The median number of receptive anal intercourse partners in the month before HIV diagnosis was the same for those who acquired HIV and those who did not. There were no significant differences in inflammatory cytokine levels in rectal mucosa between participants who did and did not experience HIV seroconversion at any time point. CONCLUSIONS: Despite a surge in viral replication during acute infection, findings from this study suggest that there is no prolonged effect of HIV-1 seroconversion on inflammatory cytokine levels in the rectal mucosa. Copyrighten_US
dc.description.sponsorshipNational Institute of Allergy and Infectious Diseasesen_US
dc.formatapplication/pdfen_US
dc.language.isoengen_US
dc.publisherNLM (Medline)en_US
dc.relation.urlhttps://journals.lww.com/jaids/Abstract/2021/04150/Brief_Report__HIV_1_Seroconversion_Is_Not.10.aspxen_US
dc.rightsinfo:eu-repo/semantics/embargoedAccessen_US
dc.sourceUniversidad Peruana de Ciencias Aplicadas (UPC)es_PE
dc.sourceRepositorio Academico - UPCes_PE
dc.subjectHIV-1 Seroconversionen_US
dc.subjectRectal Mucosal Inflammationen_US
dc.subjectInflammatory cytokinesen_US
dc.subjectRectal Mucosal Inflammationen_US
dc.subjectSecondary analysisen_US
dc.subjectHIV prevention trialen_US
dc.subjectPeruen_US
dc.titleBrief Report: HIV-1 Seroconversion Is Not Associated With Prolonged Rectal Mucosal Inflammationen_US
dc.typeinfo:eu-repo/semantics/articleen_US
dc.identifier.eissn19447884
dc.identifier.journalJournal of acquired immune deficiency syndromes (1999)en_US
dc.description.peerreviewRevisión por pareses_PE
dc.identifier.eid2-s2.0-85102658147
dc.identifier.scopusidSCOPUS_ID:85102658147
dc.source.journaltitleJournal of acquired immune deficiency syndromes (1999)
dc.source.volume86
dc.source.issue5
dc.source.beginpagee134
dc.source.endpagee138
dc.identifier.isni0000 0001 2196 144X


This item appears in the following Collection(s)

Show simple item record