Brief Report: HIV-1 Seroconversion Is Not Associated With Prolonged Rectal Mucosal Inflammation
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Authors
Blair, Cheríe S.Lake, Jordan E.
Passaro, Ryan C.
Chavez-Gomez, Susan
Segura, Eddy R.
Elliott, Julie
Fulcher, Jennifer A.
Shoptaw, Steven
Cabello, Robinson
Clark, Jesse L.
Issue Date
2021-04-15Keywords
HIV-1 SeroconversionRectal Mucosal Inflammation
Inflammatory cytokines
Rectal Mucosal Inflammation
Secondary analysis
HIV prevention trial
Peru
Metadata
Show full item recordPublisher
NLM (Medline)Journal
Journal of acquired immune deficiency syndromes (1999)DOI
10.1097/QAI.0000000000002601Additional Links
https://journals.lww.com/jaids/Abstract/2021/04150/Brief_Report__HIV_1_Seroconversion_Is_Not.10.aspxAbstract
OBJECTIVE: Determine the impact of HIV-1 seroconversion on inflammatory cytokines in the rectal mucosa. SETTING: Secondary analysis of data from men who have sex with men and transgender women who participated in a HIV prevention trial Lima, Peru. METHODS: From July to December 2017, 605 men who have sex with men and transgender women were screened for rectal gonorrhea/chlamydia (GC/CT). Fifty GC/CT-positive cases were randomly selected and matched with 52 GC/CT-negative controls by age and number of receptive anal intercourse partners in the last month. All participants were HIV-negative at baseline and those with GC/CT at baseline and/or follow-up received appropriate antibiotic therapy. Participants underwent sponge collection of rectal secretions for the measurement of inflammatory cytokines (IL-1β, IL-6, IL-8, and TNF-α) and were screened for rectal GC/CT and HIV at baseline, 3 months, and 6 months. Wilcoxon rank-sum tests compared inflammatory cytokine levels between participants diagnosed with HIV during follow-up and persons who remained HIV-negative. RESULTS: Eight participants were diagnosed with HIV at the 3-month (n = 6) or 6-month (n = 2) visit. The median number of receptive anal intercourse partners in the month before HIV diagnosis was the same for those who acquired HIV and those who did not. There were no significant differences in inflammatory cytokine levels in rectal mucosa between participants who did and did not experience HIV seroconversion at any time point. CONCLUSIONS: Despite a surge in viral replication during acute infection, findings from this study suggest that there is no prolonged effect of HIV-1 seroconversion on inflammatory cytokine levels in the rectal mucosa. CopyrightType
info:eu-repo/semantics/articleRights
info:eu-repo/semantics/embargoedAccessLanguage
engDescription
El texto completo de este trabajo no está disponible en el Repositorio Académico UPC por restricciones de la casa editorial donde ha sido publicado.EISSN
19447884Sponsors
National Institute of Allergy and Infectious Diseasesae974a485f413a2113503eed53cd6c53
10.1097/QAI.0000000000002601
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