Conjunctival squamous cell carcinoma: Prognostic factors for the recurrence and metastasis and clinicopathological characteristics at an oncological hospital in Peru
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Authors
Cruzado-Sanchez, DeivyTellez, Walter Andree
Villarreal-Aguilar, Beltran
Melendez, Monica
Olivera, Anibal
Moran, Fiorella
Serpas-Frias, Solon
Cordero-Garcia, Raul
Issue Date
2020-07-01
Metadata
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BMJ Publishing GroupJournal
British Journal of OphthalmologyDOI
10.1136/bjophthalmol-2019-314058Additional Links
https://pubmed.ncbi.nlm.nih.gov/31604702/Abstract
Background/aims Conjunctival squamous cell carcinoma (CSCC) is the most frequent malignant tumour of the conjunctiva, with scarce recurrence and infrequent metastasis. The purpose of this study is to describe the clinical and pathological characteristics of this neoplasm and to identify the prognostic factors for recurrence and metastasis in a cancer hospital in Peru. Materials and method A longitudinal, retrospective study of 176 consecutive patients diagnosed with SCC of the conjunctiva. Sociodemographic and clinical characteristics were evaluated. In addition, Kaplan-Meier curves were performed, and Cox regression was used to determine prognostic factors for recurrence and metastasis over time. Result Only 12.5% presented tumour size ≤5 mm. The highest proportion according to the histopathological type was the well-differentiated infiltrative forms (40.9%), and according to tumour, node, metastases (TNM), stage T3 was the most frequent (31.3%). The most performed initial treatment was orbital exenteration (38.6%). The proportion of recurrence was 6.8% and 8.0% for metastasis. The annual survival rate was 7% and the annual metastasis rate was 6%; for recurrence after 5 years, the survival rate was 11% and the metastasis rate was 14%. No prognostic factor evaluated was significant. Conclusion This is the most extensive patient study in Latin America with CSCC, with a high proportion of advanced histopathological grade, TNM stages, and radical treatments such as exenteration. Recurrence rates on average are similar to other reported studies, and it describes the rates of metastasis that have been poorly described in the literature.Type
info:eu-repo/semantics/articleRights
info:eu-repo/semantics/embargoedAccessLanguage
engISSN
00071161EISSN
14682079ae974a485f413a2113503eed53cd6c53
10.1136/bjophthalmol-2019-314058
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