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dc.contributor.authorPalomares-Reyes, Carlos*
dc.contributor.authorSilva-Caso, Wilmer*
dc.contributor.authordel Valle, Luis J.*
dc.contributor.authorAguilar-Luis, Miguel Angel*
dc.contributor.authorWeilg, Claudia*
dc.contributor.authorMartins-Luna, Johanna*
dc.contributor.authorViñas-Ospino, Adriana*
dc.contributor.authorStimmler, Luciana*
dc.contributor.authorMallqui Espinoza, Naysha*
dc.contributor.authorAquino Ortega, Ronald*
dc.contributor.authorEspinoza Espíritu, Walter*
dc.contributor.authorMisaico, Erika*
dc.contributor.authordel Valle-Mendoza, Juana*
dc.date.accessioned2019-03-04T23:04:04Z
dc.date.available2019-03-04T23:04:04Z
dc.date.issued2019-04
dc.identifier.issn12019712
dc.identifier.doi10.1016/j.ijid.2019.01.022
dc.identifier.urihttp://hdl.handle.net/10757/625181
dc.descriptionThis work was supported by Cienciativa of CONCYTEC Peru, under contract number 164-2016-FONDECYT, and the Programa Nacional de Innovación para la Competitividad y Productividad (Innóvate Perú), under contract number 116-PNICP-PIAP-2015.en_US
dc.description.abstractBackground: Huánuco is a central eastern region of Peru whose geography includes high forest and low jungle, as well as a mountain range that constitutes the inter-Andean valleys. It is considered a region endemic for dengue due to the many favorable conditions that facilitate transmission of the virus. Methods: A total of 268 serum samples from patients in Huánuco, Peru with an acute febrile illness were assessed for the presence of dengue virus (DENV) via RT-PCR and NS1, IgM, and IgG ELISA during December 2015 and March 2016. Results: DENV was detected in 25% of samples via RT-PCR, 19% of samples by NS1 antigen ELISA, and 10.5% of samples by IgM ELISA. DENV IgG was detected in 15.7% of samples by ELISA. The most frequent symptoms associated with fever across all groups were headache, myalgia, and arthralgia, with no significant difference between the four test methods Conclusions: In this study, DENV was identified in up to 25% of the samples using the standard laboratory method. In addition, a correlation was established between the frequency of positive results and the serological tests that determine NS1, IgM, and IgG. There is an increasing need for point-of-care tests to strengthen epidemiological surveillance in Peru.en_US
dc.formatapplication/pdfen_US
dc.language.isoengen_US
dc.publisherElsevier B.V.en_US
dc.relation.urlhttps://linkinghub.elsevier.com/retrieve/pii/S1201971219300335en_US
dc.rightsinfo:eu-repo/semantics/openAccess*
dc.rightsAttribution-NonCommercial-ShareAlike 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/3.0/us/*
dc.sourceUniversidad Peruana de Ciencias Aplicadas (UPC)es_PE
dc.sourceRepositorio Academico - UPCes_PE
dc.subjectArbovirusen_US
dc.subjectDengueen_US
dc.subjectDENVen_US
dc.subjectDiagnosisen_US
dc.subjectPeruen_US
dc.titleDengue diagnosis in an endemic area of Peru: Clinical characteristics and positive frequencies by RT-PCR and serology for NS1, IgM, and IgGen_US
dc.typeinfo:eu-repo/semantics/articleen_US
dc.identifier.journalInternational Journal of Infectious Diseasesen_US
dc.description.peerreviewRevisión por pareses_PE
dc.description.peerreviewRevisión por pareses_PE
dc.contributor.email[email protected]es_PE
dc.source.journaltitleInternational Journal of Infectious Diseases
dc.source.volume81
dc.source.beginpage31
dc.source.endpage37
refterms.dateFOA2019-03-04T23:04:04Z
dc.identifier.isni0000 0001 2196 144X


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