Dengue diagnosis in an endemic area of Peru: Clinical characteristics and positive frequencies by RT-PCR and serology for NS1, IgM, and IgG
dc.contributor.author | Palomares-Reyes, Carlos | * |
dc.contributor.author | Silva-Caso, Wilmer | * |
dc.contributor.author | del Valle, Luis J. | * |
dc.contributor.author | Aguilar-Luis, Miguel Angel | * |
dc.contributor.author | Weilg, Claudia | * |
dc.contributor.author | Martins-Luna, Johanna | * |
dc.contributor.author | Viñas-Ospino, Adriana | * |
dc.contributor.author | Stimmler, Luciana | * |
dc.contributor.author | Mallqui Espinoza, Naysha | * |
dc.contributor.author | Aquino Ortega, Ronald | * |
dc.contributor.author | Espinoza Espíritu, Walter | * |
dc.contributor.author | Misaico, Erika | * |
dc.contributor.author | del Valle-Mendoza, Juana | * |
dc.date.accessioned | 2019-03-04T23:04:04Z | |
dc.date.available | 2019-03-04T23:04:04Z | |
dc.date.issued | 2019-04 | |
dc.identifier.issn | 12019712 | |
dc.identifier.doi | 10.1016/j.ijid.2019.01.022 | |
dc.identifier.uri | http://hdl.handle.net/10757/625181 | |
dc.description | This work was supported by Cienciativa of CONCYTEC Peru, under contract number 164-2016-FONDECYT, and the Programa Nacional de Innovación para la Competitividad y Productividad (Innóvate Perú), under contract number 116-PNICP-PIAP-2015. | en_US |
dc.description.abstract | Background: Huánuco is a central eastern region of Peru whose geography includes high forest and low jungle, as well as a mountain range that constitutes the inter-Andean valleys. It is considered a region endemic for dengue due to the many favorable conditions that facilitate transmission of the virus. Methods: A total of 268 serum samples from patients in Huánuco, Peru with an acute febrile illness were assessed for the presence of dengue virus (DENV) via RT-PCR and NS1, IgM, and IgG ELISA during December 2015 and March 2016. Results: DENV was detected in 25% of samples via RT-PCR, 19% of samples by NS1 antigen ELISA, and 10.5% of samples by IgM ELISA. DENV IgG was detected in 15.7% of samples by ELISA. The most frequent symptoms associated with fever across all groups were headache, myalgia, and arthralgia, with no significant difference between the four test methods Conclusions: In this study, DENV was identified in up to 25% of the samples using the standard laboratory method. In addition, a correlation was established between the frequency of positive results and the serological tests that determine NS1, IgM, and IgG. There is an increasing need for point-of-care tests to strengthen epidemiological surveillance in Peru. | en_US |
dc.format | application/pdf | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Elsevier B.V. | en_US |
dc.relation.url | https://linkinghub.elsevier.com/retrieve/pii/S1201971219300335 | en_US |
dc.rights | info:eu-repo/semantics/openAccess | * |
dc.rights | Attribution-NonCommercial-ShareAlike 3.0 United States | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-sa/3.0/us/ | * |
dc.source | Universidad Peruana de Ciencias Aplicadas (UPC) | es_PE |
dc.source | Repositorio Academico - UPC | es_PE |
dc.subject | Arbovirus | en_US |
dc.subject | Dengue | en_US |
dc.subject | DENV | en_US |
dc.subject | Diagnosis | en_US |
dc.subject | Peru | en_US |
dc.title | Dengue diagnosis in an endemic area of Peru: Clinical characteristics and positive frequencies by RT-PCR and serology for NS1, IgM, and IgG | en_US |
dc.type | info:eu-repo/semantics/article | en_US |
dc.identifier.journal | International Journal of Infectious Diseases | en_US |
dc.description.peerreview | Revisión por pares | es_PE |
dc.description.peerreview | Revisión por pares | es_PE |
dc.contributor.email | [email protected] | es_PE |
dc.source.journaltitle | International Journal of Infectious Diseases | |
dc.source.volume | 81 | |
dc.source.beginpage | 31 | |
dc.source.endpage | 37 | |
refterms.dateFOA | 2019-03-04T23:04:04Z | |
dc.identifier.isni | 0000 0001 2196 144X |
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