• English
    • español
  • English 
    • English
    • español
  • Login
View Item 
  •   Home
  • Artículos científicos
  • Pregrado
  • Facultad de Ciencias de la Salud
  • Medicina
  • View Item
  •   Home
  • Artículos científicos
  • Pregrado
  • Facultad de Ciencias de la Salud
  • Medicina
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

Browse

All of UPCCommunitiesTitleAuthorsAdvisorIssue DateSubmit DateSubjectsThis CollectionTitleAuthorsAdvisorIssue DateSubmit DateSubjectsProfilesView

My Account

LoginRegister

Quick Guides

AcercaPolíticasPlantillas de tesis y trabajos de investigaciónFormato de publicación de tesis y trabajos de investigaciónFormato de publicación de otros documentosLista de verificación

Statistics

Display statistics

Minocycline for acute stroke treatment: a systematic review and meta-analysis of randomized clinical trials

  • CSV
  • RefMan
  • EndNote
  • BibTex
  • RefWorks
Thumbnail
Name:
10.1007 s00415-018-8935-3.pdf
Size:
216.1Kb
Format:
PDF
Download
Average rating
 
   votes
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item. When enough users have cast their vote on this item, the average rating will also be shown.
Star rating
 
Your vote was cast
Thank you for your feedback
Authors
Malhotra, Konark
Chang, Jason J.
Khunger, Arjun
Blacker, David
Switzer, Jeffrey A.
Goyal, Nitin
Hernandez, Adrian V.
Pasupuleti, Vinay
Alexandrov, Andrei V.
Tsivgoulis, Georgios
Issue Date
2018-08
Keywords
Intracerebral hemorrhage
Ischemic stroke
Minocycline
Recovery
xmlui.metadata.dc.contributor.email
konark.malhotra@yahoo.com

Metadata
Show full item record
Publisher
Dr. Dietrich Steinkopff Verlag GmbH and Co. KG
Journal
Journal of Neurology
URI
http://hdl.handle.net/10757/624615
DOI
10.1007/s00415-018-8935-3
Additional Links
http://link.springer.com/10.1007/s00415-018-8935-3
Abstract
Background: Various randomized-controlled clinical trials (RCTs) have investigated the neuroprotective role of minocycline in acute ischemic stroke (AIS) or acute intracerebral hemorrhage (ICH) patients. We sought to consolidate and investigate the efficacy and safety of minocycline in patients with acute stroke. Methods: Literature search spanned through November 30, 2017 across major databases to identify all RCTs that reported following efficacy outcomes among acute stroke patients treated with minocycline vs. placebo: National Institute of Health Stroke Scale (NIHSS), Barthel Index (BI), and modified Rankin Scale (mRS) scores. Additional safety, neuroimaging and biochemical endpoints were extracted. We pooled mean differences (MD) and risk ratios (RR) from RCTs using random-effects models. Results: We identified 7 RCTs comprising a total of 426 patients. Of these, additional unpublished data was obtained on contacting corresponding authors of 5 RCTs. In pooled analysis, minocycline demonstrated a favorable trend towards 3-month functional independence (mRS-scores of 0–2) (RR = 1.31; 95% CI 0.98–1.74, p = 0.06) and 3-month BI (MD = 6.92; 95% CI − 0.92, 14.75; p = 0.08). In AIS subgroup, minocycline was associated with higher rates of 3-month mRS-scores of 0–2 (RR = 1.59; 95% CI 1.19–2.12, p = 0.002; I2 = 58%) and 3-month BI (MD = 12.37; 95% CI 5.60, 19.14, p = 0.0003; I2 = 47%), whereas reduced the 3-month NIHSS (MD − 2.84; 95% CI − 5.55, − 0.13; p = 0.04; I2 = 86%). Minocycline administration was not associated with an increased risk of mortality, recurrent stroke, myocardial infarction and hemorrhagic conversion. Conclusions: Although data is limited, minocycline demonstrated efficacy and seems a promising neuroprotective agent in acute stroke patients, especially in AIS subgroup. Further RCTs are needed to evaluate the efficacy and safety of minocycline among ICH patients.
Type
info:eu-repo/semantics/article
Rights
info:eu-repo/semantics/embargoedAccess
Language
eng
Description
El texto completo de este trabajo no está disponible en el Repositorio Académico UPC por restricciones de la casa editorial donde ha sido publicado.
ISSN
0340-5354
1432-1459
ae974a485f413a2113503eed53cd6c53
10.1007/s00415-018-8935-3
Scopus Count
Collections
Medicina

entitlement

 

DSpace software (copyright © 2002 - 2021)  DuraSpace
Quick Guide | Contact Us
Alicia
La Referencia
Open Repository is a service operated by 
Atmire NV
 

Export search results

The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.