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An evaluation of distal hair cortisol concentrations collected at delivery

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Authors
Orta, Olivia R.
Tworoger, Shelley S.
Terry, Kathryn L.
Coull, Brent A.
Gelaye, Bizu
Kirschbaum, Clemens
Sanchez, Sixto E.
Williams, Michelle A.
Issue Date
2018-04-04
Keywords
Cortisol
Hair
Pregnancy
Stress

Metadata
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Citation
An evaluation of distal hair cortisol concentrations collected at delivery 2018:1 Stress
Publisher
Taylor and Francis Ltd.
Journal
Stress
URI
http://hdl.handle.net/10757/623369
DOI
10.1080/10253890.2018.1458088
Additional Links
https://www.tandfonline.com/doi/full/10.1080/10253890.2018.1458088
Abstract
Distal hair segments collected at delivery may allow for the assessment of maternal cortisol secretion in early pregnancy, an important time window for fetal development. Therefore, an investigation of the validity of distal hair cortisol concentrations is warranted. We examined the concordance between proximal and distal hair cortisol concentrations (HCC), both representing the first trimester of pregnancy. The study population was comprised of a random sample of 97 women participating in the Pregnancy Outcomes Maternal and Infant Study, a prospective cohort study of pregnant women attending prenatal clinics in Lima, Peru. Each participant provided two hair samples: once at enrollment [mean gestational age (GA) = 13.1 weeks] and again at full-term delivery (mean GA = 39.0 weeks). Hair segments reflecting the first trimester were: 3 cm hair segments closest to the scalp on the first hair sample (proximal) and 6–9 cm from the scalp on the second hair sample (distal). HCC was determined using Luminescence Immunoassay. A subset (N = 28) had both hair segments additionally analyzed using liquid chromatography tandem mass spectrometry (LC-MS/MS). HCC values were log-transformed (logHCC), and proximal–distal differences tested using paired sample t-tests. Concordance was evaluated within and across assay types. LogHCC, measured using immunoassay, in distal hair segments was lower compared to proximal hair segments (1.35 versus 1.64 respectively; p = .02). No difference was observed using LC-MS/MS (1.99 versus 1.83, respectively; p=.33). Proximal–distal concordance was low within assay (immunoassay: Pearson = 0.27 and κ = 0.10; LC-MS/MS: Pearson = 0.37 and κ = 0.07). High correlation was observed across assays for both distal (Pearson = 0.78, p < .001; κ = 0.64) and proximal segments (Pearson = 0.96, p < .001; κ = 0.75). In conclusion, distal first-trimester hair segments collected at delivery have lower absolute HCC compared to HCC in proximal first trimester hair segments collected in early pregnancy, and are poorly concordant with HCC in proximal segments. Findings may inform the design of future studies.
Type
info:eu-repo/semantics/article
Rights
info:eu-repo/semantics/restrictedAccess
Language
eng
Description
El texto completo de este trabajo no está disponible en el Repositorio Académico UPC por restricciones de la casa editorial donde ha sido publicado.
ISSN
1025-3890
1607-8888
ae974a485f413a2113503eed53cd6c53
10.1080/10253890.2018.1458088
Scopus Count
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Medicina

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