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dc.contributor.advisorCarreazo Parsiaca, Nilton Yhuries
dc.contributor.authorParra del Riego Freundt-Thurne, Angela*
dc.contributor.authorOlivares Sparks, Andrea Sofía*
dc.date.accessioned2018-02-26T23:38:10Z
dc.date.available2018-02-26T23:38:10Z
dc.date.issued2018-01-30
dc.identifier.citation1. Sparks O, Sofía A. Características clínicas , histopatológicas y factores asociados a adenomas de alto grado y adenocarcinoma colorrectal en un hospital oncológico de Lima , Perú . Titulo abreviado : Características histológicas asociadas a lesiones Resumen [Internet]. [Lima, Perú]: Universidad Peruana de Ciencias Aplicadas (UPC); 2018. Available from: http://hdl.handle.net/10757/622886es_PE
dc.identifier.urihttp://hdl.handle.net/10757/622886
dc.description.abstractClinical and histopathological features associated with high grade dysplasia and colorectal adenocarcinoma. Aim: The aim of this study is to determine the associated factors to develop high-grade dysplasia and colorectal adenocarcinoma. Methods: This is a retrospective analytical cross-sectional study, which included all the polyps found in patient’s colonoscopies between 2014 and 2015 at Instituto Nacional de Enfermedades Neoplásicas (INEN). The primary outcome was the presence of high-grade dysplasia or colorectal adenocarcinoma. Multivariate analysis was done using the Generalized Estimating Equation (GEE) to analyze variables such as size, location, age, gender, number of polyps, personal history with the primary outcome. Results were reported in prevalence ratios (PR) and 95% confidence intervals. Results: From the 2439 patients who underwent a colonoscopy between 2014 and 2015, a total of 621 polyps from 416 patients (41.3% males and 58.7% females) were included in this study. The prevalence of high-grade dysplasia and colorectal adenocarcinoma found was 47,6%. The location of the polyps was 52,5% in the left-side and 47,5% in the right-side. Multivariate analysis showed that polyp size ≥1cm (RP=5,57, IC 95%: 4,16-7,47) and left-sided polyps (RP=1,20, IC 95%: 1,01-1,41) had higher probability to develop high-grade dysplasia or colorectal adenocarcinoma. Conclusions: An increase in polyp size and left-sided lesions are associated with high-grade dysplasia or colorectal cancer.
dc.description.uriTesises_PE
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dc.language.isospaes
dc.publisherUniversidad Peruana de Ciencias Aplicadas (UPC)es
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.sourceRepositorio Académico - UPCes_PE
dc.subjectPólipos del Colones_PE
dc.subjectNeoplasias Colorrectaleses_PE
dc.subjectPólipos Adenomatososes_PE
dc.subjectLima (Lima, Perú)es_PE
dc.subjectMedicinaes_PE
dc.titleCaracterísticas clínicas, histopatológicas y factores asociados a adenomas de alto grado y adenocarcinoma colorrectal en un hospital oncológico de Lima, Perú.es
dc.typeinfo:eu-repo/semantics/bachelorThesises
dc.contributor.departmentUniversidad Peruana de Ciencias Aplicadas (UPC)es
thesis.degree.grantorUniversidad Peruana de Ciencias Aplicadas (UPC). Facultad de Ciencias de la Saludes_PE
thesis.degree.levelLicenciaturaes_PE
thesis.degree.disciplineMedicinaes_PE
thesis.degree.nameMédico cirujanoes_PE
refterms.dateFOA2018-06-17T08:36:59Z
html.description.abstractCaracterísticas clínicas e histopatológicas asociadas a displasia de alto grado y adenocarcinoma colorrectal. Objetivo: El objetivo del estudio es evaluar los factores asociados a adenomas de alto grado y/o adenocarcinomas colorrectales. Materiales y Métodos. Estudio retrospectivo transversal analítico que incluye todos los pólipos y adenocarcinomas encontrados en las colonoscopias realizadas entre los años 2014 y 2015 en el INEN. La variable dependiente fue la presencia de displasia de alto grado y/o adenocarcinoma colorrectal. Se trabajó con análisis por clusters para maximizar el número de pólipos, mediante el modelo de ecuación estimada generalizada (EEG), a fin de evaluar la asociación entre las variables propuestas y el resultado. Los resultados fueron reportados como razón de prevalencia (RP) con intervalos de confianza al 95%. Resultados: Se realizaron colonoscopias a 2439 pacientes. Se seleccionaron a 416 pacientes (41,3% hombres) obteniéndose 621 pólipos. La prevalencia de adenomas de alto grado y adenocarcinomas fue 47,6%. De las 621 lesiones, 52,5% estuvieron en el colon distal y 47,5% en el proximal. En el análisis multivariado se encontró asociación entre los adenomas de alto grado y los adenocarcinomas colorrectales con longitud mayor a un cm (RP=5,57, IC 95%: 4,16-7,47) y ubicarse en el colon distal (RP=1,20, IC 95%: 1,01-1,41). Conclusión: Existe relación entre el tamaño mayor de un cm y la localización distal con la presencia de adenocarcinoma colorrectal y/o adenoma de alto grado de displasia.
html.description.abstractClinical and histopathological features associated with high grade dysplasia and colorectal adenocarcinoma. Aim: The aim of this study is to determine the associated factors to develop high-grade dysplasia and colorectal adenocarcinoma. Methods: This is a retrospective analytical cross-sectional study, which included all the polyps found in patient’s colonoscopies between 2014 and 2015 at Instituto Nacional de Enfermedades Neoplásicas (INEN). The primary outcome was the presence of high-grade dysplasia or colorectal adenocarcinoma. Multivariate analysis was done using the Generalized Estimating Equation (GEE) to analyze variables such as size, location, age, gender, number of polyps, personal history with the primary outcome. Results were reported in prevalence ratios (PR) and 95% confidence intervals. Results: From the 2439 patients who underwent a colonoscopy between 2014 and 2015, a total of 621 polyps from 416 patients (41.3% males and 58.7% females) were included in this study. The prevalence of high-grade dysplasia and colorectal adenocarcinoma found was 47,6%. The location of the polyps was 52,5% in the left-side and 47,5% in the right-side. Multivariate analysis showed that polyp size ≥1cm (RP=5,57, IC 95%: 4,16-7,47) and left-sided polyps (RP=1,20, IC 95%: 1,01-1,41) had higher probability to develop high-grade dysplasia or colorectal adenocarcinoma. Conclusions: An increase in polyp size and left-sided lesions are associated with high-grade dysplasia or colorectal cancer.


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