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dc.contributor.advisorMorante Cruz, Zaidaes
dc.contributor.advisorNeciosup Delgado, Silvia Patriciaes
dc.contributor.advisorSoto Tarazona, Alonso Ricardoes
dc.contributor.authorFortes Fortes, Pedro Pabloes
dc.date.accessioned2018-02-26T23:29:01Z
dc.date.available2018-02-26T23:29:01Z
dc.date.issued2018-02-06
dc.identifier.citation1. Fortes Fortes PP. Características clínicas y demográficas de los pacientes con Cáncer de Mama Triple Negativo que recibieron quimioterapia neoadyuvante y tratamiento quirúrgico en el Instituto Nacional de Enfermedades Neoplásicas entre los años 2009-2014. [Lima, Perú]: Universidad Peruana de Ciencias Aplicadas (UPC); 2018.es_PE
dc.identifier.urihttp://hdl.handle.net/10757/622883
dc.description.abstractObjective: Describe the sociodemographic and clinical characteristics of patients with triple-negative breast cancer, who underwent neoadjuvant chemotherapy and subsequent surgical intervention treated at the Instituto Nacional de Enfermedades Neoplásicas (INEN). Methods: A retrospective cohort study that included 175 patients with triple negative breast cancer, treated between 2009 and 2014, who underwent neoadjuvant chemotherapy and surgical intervention at the INEN. Through the development of a data collection form, we proceeded to obtain sociodemographic and clinical information. Pathological response was recorded from patient charts, based on the Miller-Payne classification, which assigns a histological grade based on the presence or absence of tumor cells. We used measures of central tendency and dispersion for the description of numerical variables, while absolute frequencies and percentages were used for categorical variables. Results: 175 patients were included, with an average age was 47.5 years (SD ±11.1). 47.4% of the patients had a positive family history of cancer. 45.7% of patients treated had a stage IIIB breast cancer. The most used chemotherapy regimen was paclitaxel, adriamycin and cyclophosphamide (52.6%). Of the 175 patients treated 22.9% had pathological complete response. The 5-year overall survival rate was 53.1%, with a median survival time of 2.87 years. Conclusions: The prevalence of breast cancer is high amongst the Latin-American population, especially young women. Triple negative breast cancer is exceedingly aggressive in comparison to other types of breast cancer. Despite advances in targeted therapy for breast cancer, the overall survival in triple negative breast cancer is inferior to other subtypes of breast cancer.
dc.description.uriTesises_PE
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dc.formatapplication/epubes
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dc.language.isospaes
dc.publisherUniversidad Peruana de Ciencias Aplicadas (UPC)es
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.sourceRepositorio Académico - UPCes_PE
dc.subjectNeoplasias de la mama
dc.subjectPacientes
dc.subjectDemografía
dc.subjectLima (Lima, Perú)es_PE
dc.subjectMedicinaes_PE
dc.titleCaracterísticas clínicas y demográficas de los pacientes con Cáncer de Mama Triple Negativo que recibieron quimioterapia neoadyuvante y tratamiento quirúrgico en el Instituto Nacional de Enfermedades Neoplásicas entre los años 2009-2014es
dc.typeinfo:eu-repo/semantics/bachelorThesises
dc.contributor.departmentUniversidad Peruana de Ciencias Aplicadas (UPC)es
thesis.degree.grantorUniversidad Peruana de Ciencias Aplicadas (UPC). Facultad de Ciencias de la Saludes_PE
thesis.degree.levelLicenciaturaes_PE
thesis.degree.disciplineMedicinaes_PE
thesis.degree.nameMédico cirujanoes_PE
refterms.dateFOA2018-06-15T09:34:41Z
html.description.abstractObjetivo: Describir las características sociodemográficas y clínicas en la población tratada en el Instituto Nacional de Enfermedades Neoplásicas (INEN) en pacientes con cáncer de mama triple negativo que hayan recibido quimioterapia neoadyuvante e intervenidas quirúrgicamente. Metodología: Estudio de cohorte retrospectiva que incluyó 175 pacientes con cáncer de mama triple negativo atendidos en el INEN entre los años 2009 y 2014. Se elaboró una ficha de recolección de datos, se obtuvo información sociodemográfica y clínica. Para la variable respuesta patológica, se empleó la clasificación de Miller-Payne, el cual asigna grados en basa a la ausencia, presencia parcial o total de células neoplásicas. Se empleó medidas de tendencia central y dispersión para la descripción de variables numéricas, se usaron frecuencias absolutas y porcentajes para variables categóricas. Resultados: La media de la edad fue 47,5 años (DE ±11,1). El 47,4% de los pacientes presentaron antecedentes oncológicos familiares. El estadio clínico más frecuente fue el IIIB (45,7%). El esquema de quimioterapia más usado fue Paclitaxel con Adriamicina y Ciclofosfamida (52,6%). El 22,9% tuvo una respuesta patológica completa. La sobrevida global a 5 años fue del 53,1%, con una mediana de sobrevida de 2,87 años. Conclusiones: La prevalencia de cáncer de mama es alta en la población latinoamericana, afecta sobre todo a mujeres jóvenes. De los tipos de cáncer de mama, el triple negativo es sumamente agresivo. A pesar de los avances en la terapia dirigida de cáncer de mama, la tasa de sobrevida global para el triple negativo es baja en comparación a otros subtipos.
html.description.abstractObjective: Describe the sociodemographic and clinical characteristics of patients with triple-negative breast cancer, who underwent neoadjuvant chemotherapy and subsequent surgical intervention treated at the Instituto Nacional de Enfermedades Neoplásicas (INEN). Methods: A retrospective cohort study that included 175 patients with triple negative breast cancer, treated between 2009 and 2014, who underwent neoadjuvant chemotherapy and surgical intervention at the INEN. Through the development of a data collection form, we proceeded to obtain sociodemographic and clinical information. Pathological response was recorded from patient charts, based on the Miller-Payne classification, which assigns a histological grade based on the presence or absence of tumor cells. We used measures of central tendency and dispersion for the description of numerical variables, while absolute frequencies and percentages were used for categorical variables. Results: 175 patients were included, with an average age was 47.5 years (SD ±11.1). 47.4% of the patients had a positive family history of cancer. 45.7% of patients treated had a stage IIIB breast cancer. The most used chemotherapy regimen was paclitaxel, adriamycin and cyclophosphamide (52.6%). Of the 175 patients treated 22.9% had pathological complete response. The 5-year overall survival rate was 53.1%, with a median survival time of 2.87 years. Conclusions: The prevalence of breast cancer is high amongst the Latin-American population, especially young women. Triple negative breast cancer is exceedingly aggressive in comparison to other types of breast cancer. Despite advances in targeted therapy for breast cancer, the overall survival in triple negative breast cancer is inferior to other subtypes of breast cancer.


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