Factores asociados a la sobrevida global y sobrevida libre de enfermedad en pacientes con cáncer de mama triple negativo con quimioterapia neoadyuvante y tratamiento quirúrgico en el Instituto Nacional de Enfermedades Neoplásicas entre los años 2009-2014
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AdvisorsMorante Cruz, Zaida
Neciosup Delgado, Silvia Patricia
Soto Tarazona, Alonso Ricardo
AffiliationUniversidad Peruana de Ciencias Aplicadas (UPC)
KeywordsNeoplasias de la Mama
Análisis de Supervivencia
Lima (Lima, Perú)
MetadataShow full item record
Citation1. Ruiz Huaranga, Edita Guadalupe ; Barrantes Carmen AL. Factores asociados a la Sobrevida Global y Sobrevida Libre de Enfermedad en pacientes con Cáncer de Mama Triple Negativo con quimioterapia neoadyuvante y tratamiento quirúrgico en el Instituto Nacional de Enfermedades Neoplásicas entre los años 2009-2014 [Internet]. [Lima, Perú]: Universidad Peruana de Ciencias Aplicadas (UPC); 2018. Available from: http://hdl.handle.net/10757/622882
AbstractObjective: The aim of this study is to identify associated factors with overall survival and disease-free survival in the Peruvian population attended at the Instituto Nacional de Enfermedades Neoplásicas (INEN) with triple-negative breast cancer that received neoadjuvant chemotherapy, and subsequent surgical treatment. Methods: A retrospective cohort study that included 175 patients with triple negative breast cancer with neoadjuvant chemotherapy and surgical treatment attended in the INEN between 2009 and 2014. A data collection form was drawn up to obtain sociodemographic and clinical information. For the measurement of the variable Pathological Response, defined by degrees that determine the absence, partial or total presence of neoplastic cells, the Miller-Payne classification was used, consigned in the patient's surgery report. Kaplan-Meier curves were constructed for the description of overall survival and disease-free survival. A hazard ratio (HR) was estimated in a bivariate and multivariate manner through the Cox Regression Model. Results: The factors that were associated with a lower overall survival were tumor size (HR= 1.09; 95% IC, 1.03 - 1.14; p<0.01) and lymph node involvement (HR=3.63; 95% IC, 1.98 - 6.67; p<0.00). A greater overall survival was associated with a complete pathological response (HR=0.36; 95% IC, 0.14 - 0.90; p=0.03). A total of 22.8% of patients presented complete pathological response, which corresponds to the absence of cancer cells through histological studies after neoadjuvant treatment, which was associated with a smaller tumor size (p <0.01) and conservative surgical intervention (p <0.01). No factors significantly associated with disease-free survival were found. Age was associated with disease-free survival in the bivariate analysis; however, in the multivariate analysis no statistically significant associated factors were found. Conclusions: The overall survival of patients with triple negative breast cancer in this population is negatively affected by a larger tumor size and lymph node involvement. The complete pathological response is associated with greater overall survival. No factors were found to be significantly associated with disease-free survival.
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