Asociación entre la sintomatología climatérica y la adherencia al Tratamiento Antirretroviral de Gran Actividad en mujeres peruanas en edad mediana con infección por el virus de inmunodeficiencia humana
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AdvisorsMezones Holguín, Edward
AffiliationUniversidad Peruana de Ciencias Aplicadas (UPC)
MetadataShow full item record
Citation1. Cutimanco Pacheco, Victor Alejandro ; Arriola Montenegro JJ. Asociación entre la sintomatología climatérica y la adherencia al Tratamiento Antirretroviral de Gran Actividad en mujeres peruanas en edad mediana con infección por el virus de inmunodeficiencia humana [Internet]. [Lima, Perú]: Universidad Peruana de Ciencias Aplicadas (UPC); 2018. Available from: http://hdl.handle.net/10757/622879
AbstractAssociation between climacteric symptomatology and adherence to Highly Active Antiretroviral Therapy in middle-aged Peruvian women with human immunodeficiency virus infection Objective: To evaluate the association between Climacteric Symptomatology (CS) and adherence to highly active antiretroviral therapy (A-HAART) in middle age women (40 to 59 years old) with HIV infection. Methods: We carried out a cross-sectional study in Lima, Peru. The CS was categorized in: no symptomatology (NS), mild symptomatology (MiS), moderate symptomatology (MoS) and severe symptomatology (SS), using the score of the Menopause Rating Scale (MRS). According to the global score of the Antiretroviral Treatment Adherence Evaluation Questionnaire (CEAT-HIV), the patients were classified as: adherent and non-adherent to HAART. Also, age, sexual orientation, HAART scheme, time with HIV infection, menopausal stage, risk of depression and comorbidities were measured as control variables. We performed Poisson generalized linear models with non-parametric boostrap for calculating prevalence ratios at crude (PR) and adjusted by statistical and epidemiological criteria (aPR). Results: We included 313 in the analysis, 70.6% were non-adherent to HAART. Regarding CS, 19.9% had MiS, 32.6% had MoS and 15% had SS. The probability of non-adherent was superior in women with MiS, MoS and SS that those with NS; at crude model [PR:1.79 (CI95%: 1.39 a 2.29)], [PR:1.76 (CI95%: 1.38 a 2.23)], [PR:2.07 (CI95%: 1.64 a 2.61)], as well as adjusted by statistical criteria [aPR:1.80 (CI95%: 1.41 a 2.29)], [aPR:1.72 (CI 95%: 1.36 a 2.18)], [aPR: 2.06 (CI 95%: 1.64 a 2.60)] and adjusted by epidemiological [aPR:1.84 (CI95%: 1.45 a 2.34)], [aPR:1.83 (CI 95%: 1.44 a 2.32)], [aPR:2.17 (CI 95%: 1.73 a 2.73)]; respectively. Conclusions: Our results suggest that CS is associated with A-HAART independently of the clinical and demographic variables. The exploration of the CS on the women with HIV infection could be relevant in clinical practice arena.
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