Asociación entre el consumo de alcohol y muerte en pacientes diagnosticados de tuberculosis pulmonar pansensible: Una Revisión Sistemática y Meta-análisis
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AuthorsSánchez Siancas , Johanna Edith
AdvisorsUgarte Gil, Cesar
MetadataShow full item record
CitationArturo, J., & Tarrillo, F. (2018). Asociación entre el consumo de alcohol y muerte en pacientes diagnosticados de tuberculosis pulmonar pansensible: Una Revisión Sistemática y Meta-análisis. Universidad Peruana de Ciencias Aplicadas (UPC). Retrieved from http://hdl.handle.net/10757/622839
AbstractINTRODUCTION: Tuberculosis (TB) is one of the most important infectious diseases worldwide and is considered a public health problem since it is the first cause of death associated with a single infectious agent and it’s responsible for 1.3 million deaths despite being a curable and preventable pathology. Several health strategies have been created for the management and control of this disease, however, there are barriers that prevent its proper control which leads to negative results, being the most severe death. Among these barriers, there is alcohol consumption. OBJECTIVES: To evaluate the association between alcohol consumption and death in patients diagnosed with pulmonary tuberculosis under treatment with Isoniazide, Rifampin, Pyrazinamide and Ethambutol. METHODS: A systematic search was performed in four databases: EMBASE, LILACS, PUBMED / MEDLINE and SCOPUS. We included all the bibliography found until November 2017, taking into account cohort and cases and controls studies whose subjects were adults diagnosed with pulmonary TB under first- line antiTB treatment. The measurement of alcohol consumption for the comparison of results was classified as "alcohol consumption / no alcohol consumption" and "alcoholic / nonalcoholic". RESULTS: A total of 9 studies were included, all of them cohort. Two evaluated the risk of death during treatment in those who consumed alcohol, while seven studies did so in alcoholic patients (Pooled RR of 1.57 IC 95%: 1.21 -2.04). There was no significant variation in the variance or the pooled RR when performing an analysis based on the sensitivity of the studies. CONCLUSIONS: Alcoholism increases the risk of death during TB treatment. These results will help health personnel to implement more comprehensive actions and develop follow-up and supervision strategies in these patients who are a population at risk.
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