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dc.contributor.authorBueno-Notivol, Juan*
dc.contributor.authorCalvo-Latorre, Julia*
dc.contributor.authorAlonso-Ventura, Vanesa*
dc.contributor.authorPasupuleti, Vinay*
dc.contributor.authorHernandez, Adrian V.*
dc.contributor.authorPérez-López, Faustino R.*
dc.date.accessioned2017-10-31T16:46:49Z
dc.date.available2017-10-31T16:46:49Z
dc.date.issued2017-06
dc.identifier.citationEffect of programmed exercise on insulin sensitivity in postmenopausal women 2017:1 Menopausees
dc.identifier.issn1072-3714
dc.identifier.doi10.1097/GME.0000000000000936
dc.identifier.urihttp://hdl.handle.net/10757/622340
dc.descriptionEl texto completo de este trabajo no está disponible en el Repositorio Académico UPC por restricciones de la casa editorial donde ha sido publicado.es_PE
dc.description.abstractOBJECTIVE:: We performed a systematic review and meta-analysis of randomized controlled trials (RCTs) assessing the effect of programmed exercise for at least 12 weeks, in postmenopausal women on insulin sensitivity-related outcomes (ISROs), including fasting insulin, C-peptide, insulin growth factor (IGF-1) and IGF-binding protein (IGFBP-3), Homeostatic Model Assessment-Insulin Resistance (HOMA-IR), and anthropometric variables. METHODS:: Searches were conducted in PubMed-Medline, Embase, Scopus, Web of Science, and Cochrane Library from inception through May 3, 2016, for studies published in all languages. Extracted data included characteristics of the study design, study participants, intervention, and outcome measures. Types of exercise were classified into “mid-term exercise intervention” (MTEI, 3-4 months exercise duration) and a “long-term exercise intervention” (LTEI, 6-12 months exercise duration). Risk of bias in RCTs was evaluated with the Cochrane tool. We used random-effects models for meta-analyses. We adhered to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. RESULTS:: Seven RCTS (n?=?580) evaluating the effects of programmed exercise on ISROs were included. In three RCTs, MTEI significantly lowered insulin levels (mean difference [MD] −6.50?pmol/L, 95% confidence interval [CI] −11.19, −1.82, P?=?0.006) and HOMA-IR values (MD −0.18, 95% CI −0.34, −0.03, P?=?0.02) when compared with controls. LTEI had no significant effect on insulin levels (P?=?0.19) or HOMA-IR values (P?=?0.68) in four and three RCTs, respectively. There were no significant differences between exercise intervention versus controls in circulating IGF-1, glucose, triglycerides with both MTEI and LTEI, and in IGFBP-3 with LTEI. There were significant reductions in body mass index (BMI, kg/m) (MD −1.48, 95% CI −2.48, −0.48, P?=?0.004) and in body fat percentage (MD −2.99, 95% CI −4.85, −1.14, P?=?0.01) after MTEI; and in waist circumference after both MTEI (MD −1.87, 95% CI −3.02, −0.72, P?=?0.001) and LTEI (MD −3.74, 95% CI −6.68, −0.79). Heterogeneity of effects among studies was moderate to low. CONCLUSION:: Exercising for 3 to 4 months significantly lowered insulin levels and HOMA-IR values, BMI waist circumference, and percentage body fat mass; exercising for 6 to 12 months lowered waist circumference in postmenopausal women.
dc.formatapplication/pdfes
dc.language.isoenges
dc.publisherLippincott Williams and Wilkinses
dc.relation.urlhttp://Insights.ovid.com/crossref?an=00042192-900000000-97743es
dc.rightsinfo:eu-repo/semantics/restrictedAccesses
dc.subjectC-peptidees
dc.subjectExercisees
dc.subjectHOMA-IRes
dc.subjectInsulines
dc.subjectInsulin growth factor-1es
dc.subjectPostmenopausal womenes
dc.titleEffect of programmed exercise on insulin sensitivity in postmenopausal womenes
dc.typeinfo:eu-repo/semantics/articlees
dc.identifier.journalMenopausees
dc.description.peerreviewRevisión por pareses_PE
refterms.dateFOA2018-06-15T21:53:29Z
html.description.abstractOBJECTIVE:: We performed a systematic review and meta-analysis of randomized controlled trials (RCTs) assessing the effect of programmed exercise for at least 12 weeks, in postmenopausal women on insulin sensitivity-related outcomes (ISROs), including fasting insulin, C-peptide, insulin growth factor (IGF-1) and IGF-binding protein (IGFBP-3), Homeostatic Model Assessment-Insulin Resistance (HOMA-IR), and anthropometric variables. METHODS:: Searches were conducted in PubMed-Medline, Embase, Scopus, Web of Science, and Cochrane Library from inception through May 3, 2016, for studies published in all languages. Extracted data included characteristics of the study design, study participants, intervention, and outcome measures. Types of exercise were classified into “mid-term exercise intervention” (MTEI, 3-4 months exercise duration) and a “long-term exercise intervention” (LTEI, 6-12 months exercise duration). Risk of bias in RCTs was evaluated with the Cochrane tool. We used random-effects models for meta-analyses. We adhered to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. RESULTS:: Seven RCTS (n?=?580) evaluating the effects of programmed exercise on ISROs were included. In three RCTs, MTEI significantly lowered insulin levels (mean difference [MD] −6.50?pmol/L, 95% confidence interval [CI] −11.19, −1.82, P?=?0.006) and HOMA-IR values (MD −0.18, 95% CI −0.34, −0.03, P?=?0.02) when compared with controls. LTEI had no significant effect on insulin levels (P?=?0.19) or HOMA-IR values (P?=?0.68) in four and three RCTs, respectively. There were no significant differences between exercise intervention versus controls in circulating IGF-1, glucose, triglycerides with both MTEI and LTEI, and in IGFBP-3 with LTEI. There were significant reductions in body mass index (BMI, kg/m) (MD −1.48, 95% CI −2.48, −0.48, P?=?0.004) and in body fat percentage (MD −2.99, 95% CI −4.85, −1.14, P?=?0.01) after MTEI; and in waist circumference after both MTEI (MD −1.87, 95% CI −3.02, −0.72, P?=?0.001) and LTEI (MD −3.74, 95% CI −6.68, −0.79). Heterogeneity of effects among studies was moderate to low. CONCLUSION:: Exercising for 3 to 4 months significantly lowered insulin levels and HOMA-IR values, BMI waist circumference, and percentage body fat mass; exercising for 6 to 12 months lowered waist circumference in postmenopausal women.


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