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Resistance to quinolones, cephalosporins and macrolides in Escherichia coli causing bacteraemia in Peruvian children

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Authors
Palma, Noemí
Pons, Maria J.
Gomes, Cláudia
Mateu, Judit
Riveros, Maribel
García, Wilfredo
Jacobs, Jan
García, Coralith
Ochoa, Theresa J.
Ruiz, Joaquim
Issue Date
2017-12
Keywords
Antimicrobial resistance
Bacteraemia
Extended-spectrum β-lactamase (ESBL
Macrolide resistance
Peru
Quinolone resistance
xmlui.metadata.dc.contributor.email
joruiz.trabajo@gmail.com

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Citation
Resistance to quinolones, cephalosporins and macrolides in Escherichia coli causing bacteraemia in Peruvian children 2017, 11:28 Journal of Global Antimicrobial Resistance
Publisher
Elsevier Ltd
Journal
Journal of Global Antimicrobial Resistance
URI
http://hdl.handle.net/10757/622267
DOI
10.1016/j.jgar.2017.06.011
Additional Links
http://linkinghub.elsevier.com/retrieve/pii/S2213716517301339
Abstract
Objectives To characterise the β-lactam, quinolone and macrolide resistance levels and mechanisms in 62 Escherichia coli isolates causing bacteraemia in Peruvian children. Methods Minimum inhibitory concentrations (MICs) of ciprofloxacin, nalidixic acid (NAL) and azithromycin were determined in the presence and absence of Phe-Arg-β-naphthylamide. Susceptibility to other 14 antimicrobial agents was also established. Extended-spectrum β-lactamases (ESBLs) were identified, and mutations in gyrA and parC as well as the presence of transferable mechanisms of quinolone resistance (TMQR) and macrolide resistance (TMMR) were determined. Results Fifty isolates (80.6%) were multidrug-resistant. High proportions of resistance to ampicillin (93.5%), NAL (66.1%) and trimethoprim/sulfamethoxazole (66.1%) were observed. No isolate showed resistance to carbapenems and only two isolates were resistant to nitrofurantoin. Twenty-seven isolates carried ESBL-encoding genes: 2 blaSHV-12; 13 blaCTX-M-15; 4 blaCTX-M-2; 6 blaCTX-M-65; and 2 non-identified ESBLs. Additionally, 27 blaTEM-1 and 9 blaOXA-1-like genes were detected. All quinolone-resistant isolates showed target mutations, whilst TMQR were present in four isolates. Efflux pumps played a role in constitutive NAL resistance. The association between quinolone resistance and ESBL production was significant (P = 0.0011). The mph(A) gene was the most frequent TMMR (16 isolates); msr(A) and erm(B) genes were also detected. Only one TMMR-carrying isolate [presenting mph(A) and erm(B) concomitantly] remained resistant to azithromycin when efflux pumps were inhibited. Conclusions A variety of ESBL-encoding genes and widespread of blaCTX-M-15 in Lima has been shown. The role of efflux pumps in azithromycin resistance needs to be further evaluated, as well as effective control of the use of antimicrobial agents. © 2017 International Society for Chemotherapy of Infection and Cancer
Type
info:eu-repo/semantics/article
Rights
info:eu-repo/semantics/restrictedAccess
Language
eng
Description
El texto completo de este trabajo no está disponible en el Repositorio Académico UPC por restricciones de la casa editorial donde ha sido publicado.
ISSN
22137165
ae974a485f413a2113503eed53cd6c53
10.1016/j.jgar.2017.06.011
Scopus Count
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Medicina

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