• Comparación entre las características del diagnóstico y tratamiento de la tuberculosis pulmonar en pacientes con y sin diabetes mellitus tipo 2

      Carreazo, Nilton Yhuri; Carrión Torres, Omar Jesús; Cazorla Saravia, Patrick Sebastian; De La Cruz Armijo, Frank Enrique (Universidad Peruana de Ciencias Aplicadas (UPC), 2015-02-05)
      Objetive: To observe if there are differences between two retrospective cohorts of patients with diagnosis of pulmonary tuberculosis with and without Diabetes Mellitus type 2(DM2) about sex, age, time of negativization of sputum, presence of cavitations, healing rate, duration of treatment and the proportion of change of treatment betweetn both groups. Materials and Methods: Observational study, retrospective cohort design. It was compared the characteristics of patients with TB and DM2 vs patients without DM2, TB was confirmed with clinical, culture and/or BK positive sputum smear. It was included in study 34 exposed and 133 not exposed, atended by Programa de Control de Tuberculosis between 2010 and 2012 in the Red Asistencial Rebagliati (Lima, Peru). It was made a database in Microsoft Excel 2010, and the analysis was made with STATA 10. It was estimated the hazard ratio (HR) of variables that adjusted in bivariate analysis from the Cox regression. Results: In the bivariate analysis was found that being younger than 45 years was associated with risk of having diabetes, also, having DM2 was associated to a lower expression of sympthoms of TB. Patients with DM2 have higher risk to develope cavitations, to change of treatment and a higher risk of duration of treatment for more than 6 months. The patients with TB and DM2 need a longer time for negativization of Bk sputum smear in comparison with patients with no DM2. In the analysis model adjusted Cox regression identified to be patient TB-DM2 delays negativization BK sputum RR 0,24 IC 95 % (0,09 – 0,60). Conclusions: There are demographical, clinical and radiological differences between exposed and not exposed patients. In addition, the period of negative sputum culture is higher in exposed patients.
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