• Asociación entre apoyo social percibido y aborto inducido: estudio en centros maternos infantiles de Lima, Perú

      Piscoya, Alejandro; Bernabé Ortiz, Antonio; Rodríguez Medina, Angélica Desiree; Sánchez Siancas, Luis Enrique (Universidad Peruana de Ciencias Aplicadas (UPC), 2015-02-04)
      Objective: To determine the association between perceived social support and induced abortion among women from maternal health centers in Lima, Peru. Besides, prevalence and incidence of induced abortion were estimated in this population. Material and Methods: Cross-sectional study enrolling women aged 18 to 25 years. Induced abortion was defined using one of the Rossier methods: difference between the total number of pregnancies ended in abortion and the number of spontaneous abortions, whereas perceived social support was assessed using the DUKE-UNC scale. The association between variables of interest was estimated using generalized linear models adjusting by potential confounders. Results: A total of 298 women were enrolled, mean age 21.6 (SD: 2.2) years. Low levels of social support was found in 43.6% (95%CI 38.0%–49.3%) and 17.4% (95%CI: 13.1%– 21.8%) reported at least one induced abortion. The incidence of induced abortion was 2.37 (95%CI: 1.81–3.11) per 100 persons-year of follow-up. There was evidence of the association between social support and induced abortion (RR=1.93; 95%CI: 1.13–3.30) after controlling for potential confounders. Conclusions: There was evidence of an association between perceived social support and induced abortion among women aged 18 to 25 years. The incidence of induced abortion was similar or higher than countries where abortion is legal. A great proportion of women had low levels of social support. Strategies to increase social support and reduce induced abortion rates are needed.
      Acceso abierto
    • Association between the use of protease inhibitors in Highly Active Antiretroviral Therapy (HAART) and incidence of metabolic syndrome in HIV-infected patients: A systematic review and meta-analysis

      Ugarte Gil, Cesar; Echecopar-Sabogal, Jose; D'Angelo-Piaggio, Lorenzo (Universidad Peruana de Ciencias Aplicadas (UPC), 2017-01-01)
      Introduction: Since its introduction, Highly Active Antiretroviral Treatment (HAART) has been shown to prolong the life expectancy of HIV-infected patients. HIV and HAART, especially protease inhibitors (PIs), have been associated with the occurrence of Metabolic Syndrome (MS). The objective of this systematic review and meta-analysis was to determine whether there is an association between the use of PIs and the incidence of MS in HIV-infected patients. Methods: A comprehensive search (including databases such as MEDLINE/PubMed, CENTRAL, LILACS and EMBASE) was performed. Observational studies published until November 2015 were included. Inclusion criteria for primary studies were: study population comprised HIV-infected patients aged 18 years or older and who were receiving HAART; patients assessed according to their use of PIs; DM as defined by the primary study. Heterogeneity was assessed and a pooled analysis was performed using a random-effects model. Results: 3 articles met the inclusion criteria, describing 586 HIV patients. Use of PIs was associated with the development of MS (RR: 2.11; 95% CI 1.28 to 3.48; 〖Chi〗^2:0.04, I^2: 0%; p-value 0.003). Conclusion: Use of PIs in HIV-infected patients is associated with an increased risk of MS. These findings are of relevance for future public policy because it will increase the interest in screening and prevention of MS in an expanding population.
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    • Razón Mortalidad-Incidencia como indicador de supervivencia de cáncer a cinco años en Lima Metropolitana

      Payet Meza, Eduardo; Segura, Eddy R.; Cordero Morales, Alejandra; Savitzky Franco, María José; Stenning Persivale, Karoline Andrea (Universidad Peruana de Ciencias Aplicadas (UPC), 2017-03-02)
      Introducción: El complemento de la Razón Mortalidad-Incidencia [1 - RMI], ha sido sugerido como un proxy válido para hallar la supervivencia a cinco años de cáncer. Su validez aún no ha sido reportada en el Perú. El presente estudio busca establecer si esta razón guarda una correlación directa con la supervivencia de los pacientes con cáncer a cinco años en Lima Metropolitana. Materiales y Métodos: Se utilizó el Registro de Cáncer de Lima Metropolitana (RCLM) del 2004-2005 de donde se obtuvo la incidencia y mortalidad por tipo de neoplasia y la supervivencia observada. A partir de estas, se buscó correlacionar [1 - RMI] con la supervivencia observada a cinco años de diez tipos de neoplasias seleccionadas (Mama, estómago, próstata, tiroides, pulmón, colon, linfoma no Hodgkin, cuello uterino, hígado y leucemia) mediante el modelo de regresión lineal. Resultados: Considerando los diez tipos de cáncer estudiados, se realizó una regresión lineal en donde se encontró correlación entre la supervivencia observada a cinco años y [1-RMI]. De las diez neoplasias, cinco tuvieron una correlación muy alta, siendo estas: Mama, próstata, hígado, tiroides y leucemia. Conclusión: El complemento de la Razón Mortalidad Incidencia [1-RMI] es una buena herramienta para la aproximación de la supervivencia observada a cinco años para los diez tipos de neoplasias estudiadas. Demostrándose la validez del modelo como predictor de supervivencia a cinco años en pacientes con cáncer, para Lima Metropolitana.
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