• Antibiotic resistance in Bartonella bacilliformis clinical isolates from an endemic area of Peru

      Silva-Caso, Wilmer; J. Ruiz; Del Valle Mendoza, Juana; Pons, Maria J (Elsevier B.V., 2015-10-15)
      Bartonella bacilliformis is a facultative, intracellular, aerobic, Gram-negative coccobacillus causing the so-called Carrión's disease, a human infection endemic to specific areas mainly inhabited by low-income communities of Peru but also present in other Andean communities. It is considered a truly neglected tropical disease and is transmitted through the bite of female sandflies of the genus Lutzomyia [1]. Carrión's disease has two different clinical presentations; an initial febrile and haemolytic anaemia phase, known as Oroya fever, which has a mortality rate ranging from 44% to 88% in untreated patients; and a second phase characterised by the development of dermal eruptions known as Peruvian wart [1,2]. 
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    • Carrion’s disease: an eradicable illness?

      Gomes, Cláudia; Pons, Maria J.; Del Valle Mendoza, Juana Mercedes; Ruiz, Joaquim; ma.pons.cas@gmail.com (BioMed Central Ltd., 2016-12-01)
      Carrion’s disease is a neglected tropical disease caused by Bartonella bacilliformis, a vector-borne pathogen restricted to the Andean valleys of Peru, Ecuador and Colombia. Carrion’s disease is a biphasic illness; in the acute phase the case-fatality rate can be as high as 88 %, related to high parasitemia, arriving to almost all erythrocytes, and secondary bacterial infections close related with the development of transient immunosuppression in the earlier illness phases. In addition, there are an undefined number of asymptomatic carriers that are reservoirs of the etiological agent of Carrion’s disease in endemic areas, they make take into account due to they are the perpetuators of this disease. The actual scenario of Carrion’s disease, in which the illness is arriving to new areas, due to the expansion of the vector’s distribution, suggests that now may be a crucial time to design a strategy focusing on its elimination.
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    • Co-infection with Bartonella bacilliformis and Mycobacterium spp. in a coastal region of Peru

      Silva-Caso, Wilmer; Mazulis, Fernando; Weilg, Claudia; Aguilar-Luis, Miguel Angel; Sandoval, Isabel; Correa-Nuñez, German; Li, Dongmei; Song, Xiuping; Liu, Qiyong; del Valle-Mendoza, Juana (BioMed Central Ltd., 2017-12-01)
      Objective This study investigated an outbreak of Bartonellosis in a coastal region in Peru. Results A total of 70 (n = 70) samples with clinical criteria for the acute phase of Bartonellosis and a positive peripheral blood smear were included. 22.85% (n = 16) cases of the samples were positive for Bartonella bacilliformis by PCR and automatic sequencing. Of those positive samples, 62.5% (n = 10) cases were positive only for B. bacilliformis and 37.5% (n = 6) cases were positive to both Mycobacterium spp. and B. bacilliformis. The symptom frequencies were similar in patients diagnosed with Carrion’s disease and those co-infected with Mycobacterium spp. The most common symptoms were headaches, followed by malaise and arthralgia.
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    • Infective endocarditis due to Bartonella bacilliformis associated with systemic vasculitis: a case report

      Peñafiel-Sam, Joshua; Alarcón-Guevara, Samuel; Chang-Cabanillas, Sergio; Perez-Medina, Wilkerson; Mendo-Urbina, Fernando; Ordaya-Espinoza, Eloy; Universidad Peruana de Ciencias Aplicadas, Peru; Universidad Peruana de Ciencias Aplicadas, Peru; Universidad Peruana de Ciencias Aplicadas, Peru; Hospital Nacional Edgardo Rebagliati Martins, Perú; Universidad Peruana de Ciencias Aplicadas, Peru; Hospital Nacional Edgardo Rebagliati Martins, Perú; Universidad Peruana de Ciencias Aplicadas, Peru; University of Minnesota, USA; eeordaya@umn.edu (Sociedade Brasileira de Medicina Tropical - SBMT, 2017-09)
      Infective endocarditis due to Bartonella bacilliformis is rare. A 64-year-old woman, without previous heart disease, presented with 6 weeks of fever, myalgias, and arthralgias. A systolic murmur was heard on the tricuspid area upon examination, and an echocardiogram showed endocardial lesions in the right atrium. Bartonella bacilliformis was isolated in blood cultures, defining the diagnosis of infective endocarditis using Duke’s criteria. Subsequently, the patient developed clinical and laboratory features compatible with antineutrophil cytoplasmic antibody-associated vasculitis. This case presents an uncommon complication of B. bacilliformis infection associated with the development of systemic vasculitis.
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    • Molecular identification of Bartonella bacilliformis in ticks collected from two species of wild mammals in Madre de Dios: Peru

      del Valle-Mendoza, Juana; Rojas-Jaimes, Jesús; Vásquez-Achaya, Fernando; Aguilar-Luis, Miguel Angel; Correa-Nuñez, Germán; Silva-Caso, Wilmer; Lescano, Andrés G.; Song, Xiuping; Liu, Qiyong; Li, Dongmei; juana.delvalle@upc.pe; jesus.rojas.jaimes@gmail.com; fernando.vasquez.achaya@gmail.com; ma23aguilar@gmail.com; biologo.geo@yahoo.com; gian_will@hotmail.com (BioMed Central Ltd., 2018-06)
      Objective: To study the presence of Bartonella bacilliformis in ticks collected from two wild mammals in Madre de Dios, Peru. Results: A total of 110 ticks were collected. Among the 43 Amblyomma spp. extracted from the 3 Tapirus terrestris only 3 were positive for B. bacilliformis. In addition, 12 out of the 67 Rhipicephalus (Boophilus) microplus obtained from the 3 Pecari tajacu were positive for B. bacilliformis. For the first time B. bacilliformis have been detected in arthropods other than Lutzomyia spp. Further studies are required to elucidate the possible role of ticks in the spread of South American Bartonellosis.
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