RSS 1.0Facultad de Ciencias de la Salud
Recent Submissions
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A comparative analysis of heme vs non-heme iron administration: a systematic review and meta-analysis of randomized controlled trials(Springer Science and Business Media Deutschland GmbH, 2025-02-01)Background and purpose: Bioavailability studies and observational evidence suggest that heme iron (HI) may have greater impact on iron status indicators compared with non-heme iron (NHI). This systematic review and meta-analysis aimed to review the current evidence on the effect of the administration of HI compared with NHI for improving iron status in non-hospitalized population groups. Methods: We searched Pubmed, CENTRAL, Scopus, Web of Science, and LILACS from inception to July 2024. There was no language restriction or exclusion based on age or iron status. Only randomized controlled trials comparing HI with NHI were considered. A random-effects meta-analysis was performed to compare the effect of treatments for iron status indicators and total side effects (including gastrointestinal side effects). We measured the certainty of the evidence (CoE) using GRADE assessment. Results: After screening 3097 articles, 13 studies were included. Most of the interventions used HI in low doses combined with NHI. The meta-analysis showed higher hemoglobin increases in children with anemia or low iron stores receiving HI (MD 1.06 g/dL; 95% CI: 0.34; 1.78; CoE: very low). No statistically significant difference between interventions were found for any iron status indicator in the other population subgroups (CoE: very low). Participants receiving HI had a 38% relative risk reduction of total side effects compared to NHI (RR 0.62; 95% CI 0.40; 0.96; CoE: very low). Conclusion: The current evidence comparing HI with NHI is very limited, preliminary findings suggest that interventions using HI may result in fewer side effects and may be superior in children with iron deficiency or anemia. However, given the very low certainty of the evidence, these results need further investigation through high-quality clinical trials. Protocol registration: CRD42023483157.Acceso abierto
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Adaptation, validation, and factorial invariance of a scale to assess the quality of virtual courses developed for Peruvian health sciences students during the COVID-19 pandemic(Elsevier Espana S.L.U, 2025-05-01)Objective: To adapt, validate and evaluate the factorial invariance of a scale that assess the quality of virtual courses (QVC) among health sciences students (HSS). Methods: Cross-sectional study developed with virtual surveys to HSS to assess the QVC of the 2020 academic year, as well as sociodemographic and educational characteristics. Content-based validity was estimated with VAiken. Validity based on internal structure was assessed with the Goodness of Fit Indices (GFI) in the Confirmatory Factor Analysis (CFA), considering adequate the comparative fit index (CFI) and the Tucker-Lewis index (TLI) greater than 0.90, as well as values of the standardized root mean square residual (SRMR) and root mean square error of approximation (RMSEA) less than 0.08. Factor invariance was considered adequate when the ΔCFI ≤ 0.010 and the ΔRMSEA ≤ 0.015 between models at different levels. Reliability was assessed with the alpha and omega index. Results: Of the 629 HSS included, 62.96% were women, 49.76% studied human medicine and 316 other health areas. The VAiken was 0.86 on the instrument. The CFA showed adequate GFI (CFI = 0.956, TLI = 0.950, RMSEA = 0.073 and SRMR = 0.044). The ΔCFI (≤ 0.002) and ΔRMSEA (≤ 0.004) between models were estimated for the characteristics evaluated (sex, place of residence, study career, stage of training and type of university management). Reliability indices were greater than 0.85 in the domains. Conclusion: The 30-item scale and six domains to assess QVC developed for HSS in Peru showed adequate evidence of validity and reliability. In addition, it showed adequate factorial invariance in different sociodemographic and educational contexts of HSS.Acceso restringido temporalmente
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Longitudinal transitions of the double burden of overweight and stunting from childhood to early adulthood in India, Peru, and Vietnam(Oxford University Press, 2024-12-01)Background: Examining trajectories of undernutrition and overnutrition separately limits understanding of the double burden of malnutrition. We investigated transitions between normal, stunting, overweight and concurrent stunting and overweight (CSO) and associations with sociodemographic factors in children and adolescents. Methods: We used data from the Young Lives cohort in India, Peru and Vietnam, which follow children 1-15 (N = 5413) and 8-22 years (N = 2225) over five rounds between 2002 and 2016. We estimated transitions between nutritional states using a Markov chain model and estimated sociodemographic associations employing a logit parametrization. Results: Transitions into stunting peaked in ages 1-5 years (India: 22.9%, Peru: 17.6%, Vietnam: 14.8%), while stunting reversal was highest during adolescence across all countries. Transitions into overweight peaked in ages 19-22, while overweight reversal increased in ages 1-5 and 12-15 years. Transitions away from stunting to overweight were rare; more commonly, stunted individuals developed overweight while remaining stunted, leading to a CSO state. In Peru, 20.2% of 19-year-olds who were stunted reached CSO by age 22, with 4% shifting from stunted to overweight. Reversion to a normal state is least likely for those in a CSO state. Household wealth gradually reduced the likelihood of transitioning into stunting [odds ratios (ORs) for wealthiest quartile in Peru: 0.29, 95% confidence interval (CI) 0.20-0.41; India: 0.43, 95% CI 0.32-0.57; Vietnam: 0.36, 95% CI 0.26-0.50), with stunting reversal only being more likely in the two wealthiest quartiles across all countries (ORs for wealthiest quartile in Peru: 2.39, 95% CI 1.57-3.65; India: 1.28, 95% CI 1.05-1.54; Vietnam: 1.89, 95% CI 1.23-2.91). In Vietnam, only the richest quartile was at higher risk of transitioning into overweight (OR 1.87, 95% CI 1.28-2.72), while in Peru and India, the risk gradually rose across all wealth quartiles (ORs for wealthiest quartile in Peru: 2.84, 95% CI 2.14-3.77; India: 2.99, 95% CI 1.61-5.54). Conclusions: Childhood and adolescence represent critical periods for prevention and reversal of stunting and overweight, thereby averting the development of CSO later in life. Context-specific interventions are crucial for preventing disparate transitions towards the double burden of malnutrition across socioeconomic groups.Acceso restringido temporalmente
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Quantitative MODS-Wayne assay for rapid detection of pyrazinamide resistance in Mycobacterium tuberculosis from sputum samples(American Society for Microbiology, 2024-12-01)Tuberculosis (TB) remains a significantglobal health challenge, exacerbated by the emergence of drug-resistant strains, such as those resistant to pyrazinamide (PZA). The current scarcity of affordableand precise quantitative diagnostic tests for PZA resistance underscores the urgent need for more accessible diagnostic tools. We evaluated PZA susceptibility in 264 TB-positive samples by quantifying pyrazinoic acid (POA) production, using both the MODS-Wayne qualitative assay and our newly developed quantitative approach (MODS-WQ). The MODS-WQ was assessed in 7H9 medium (MODS-WQ7H9) or citrate buffer(MODS-WQCB), with POA levels measured via spectrophotometry against a calibration curve. PZA susceptibility determinations were based on a composite reference standard. Associations between POA levels and pyrazinamidase mutations were explored. The composite standard detected PZA resistance in 23.5% of the samples, which accounts for 62.8% of the multidrug-resistant (MDR) samples. The MODS-WQ established specificPOA cutoffsof 123.25 μM for MODS-WQ7H9 and 664.7 μM for MODS-WQCB, with sensitivities of 81.3% and 92.3% and specificitiesof 77.2% and 95.9%, respectively. Notably, samples with mutations in the pyrazinamidase metal-binding site exhibited significantlylower POA levels compared with mutations in the enzyme periphery. Furthermore, a significantcorrelation was found between POA production and PZA resistance, Bactec Growth Index, and minimum inhibitory concentration (MIC) values. This study presents a novel, direct, and accessible susceptibility test for PZA resistance that quantifiesPOA, enhancing the detection capabilities for this condition. The citrate-bufferedMODS-WQ assay demonstrated high sensitivity and specificityfor quantifying POA, confirmingthat POA production is a reliable indicator of PZA resistance.Acceso restringido temporalmente
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An in vitro protocol to assay mRNA translation inhibitors using the fluorescent assembly of the split-GFP(Cell Pres, 2024-12-20)Here, we present an in vitro protocol to assay mRNA translation inhibitors using the fluorescent assembly of split-GFP for translation test (FAST), based on the small fragment GFP11 binding to GFP1-10fast. We detail the expression and purification of the GFP1-10fast protein, DNA template amplification, in vitro GFP11-tagged CspA synthesis, FAST detection of the GFP11-tagged protein, and optional recovery of the fluorescent complex. In vitro synthesis of GFP11 maximizes the molar yield of synthesized proteins, providing enhanced sensitivity to test translation inhibitors. For complete details on the use and execution of this protocol, please refer to Pham et al.Acceso restringido temporalmente
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Fibromatosis gingival. Diagnóstico y tratamiento: Reporte de un caso Ceccarelli-Calle JF, Ricaldi-Camahualí J, Berastain-Arenas JF. Fibromatosis gingival. Diagnóstico(Universidad Peruana Cayetano Heredia, 2014-08-19)La fibromatosis gingival es una deformidad desarrollada de baja prevalencia. Las características clínicas de la FG incluyen tejidos gingivales hiperplásicos de consistencia firme y nodular, presentándose en forma generalizada o localizada. Las características histológicas de la FG incluyen principalmente tejido conectivo con un denso infiltrado rico en fibras de colágeno y un epitelio denso con papilas epiteliales largas Se presenta un reporte de caso de un paciente masculino de 12 años referido para su tratamiento al servicio de Periodoncia e Implantes dentales de la Clínica Estomatológica Central de la Universidad Peruana Cayetano Heredia.Acceso abierto
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Spatial and socioeconomic inequalities in the access to safe drinking water in Peruvian households(IWA Publishing, 2023-03-31)"El acceso al agua potable ha aumentado en el Perú en las últimas décadas, del 47% (2008) al 52% (2018). Sin embargo, dicho acceso difieren según factores socioeconómicos y regionales. Así, este estudio tuvo como objetivo evaluar la desigualdad socioeconómica en el acceso a servicios seguros agua potable e identificar su distribución espacial. Realizamos un estudio transversal basado en el análisis de datos secundarios del año 2021. Encuesta de Demografía y Salud del Perú. El acceso al agua potable fue una variable ficticia categorizada como segura si el cloro residual La concentración fue de 0,5 mg/L. A nivel nacional, el 29,22% de los hogares tenía acceso a agua potable. Una desigualdad a favor de los ricos en el acceso a la seguridad. Se observó agua potable. La distribución espacial fue agrupada. Se encontraron importantes puntos críticos en el sur y el centro del país; sin embargo, se encontraron puntos fríos en la mayoría de las áreas. El análisis SaTScan identificó 32 y 63 grupos importantes con riesgo alto y bajo de tener acceso al agua potable, respectivamente. En conclusión, aproximadamente uno de cada cuatro hogares peruanos tiene acceso a agua potable segura agua, que se concentraba principalmente entre los hogares más ricos. Desigualdades intra e interdepartamentales en el acceso al agua potable. Se encontraron agua, con varios grupos de alto riesgo."Acceso abierto
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Evaluación de las características nutricionales de alimentos y bebidas procesados publicitados en medios televisivos de Perú, 2021(SciELO Agencia Nacional de Investigacion y Desarrollo (ANID), 2023-09-01)El objetivo fue describir las características y el perfil nutricional de los alimentos y bebidas procesados publicitados durante el horario de protección al menor (6 am a 10 pm, según la regulación peruana) los dos canales de mayor audiencia de la televisión peruana. En este estudio transversal se grabaron 448 horas de contenido televisivo de 14 días aleatorios de 6:00 am a 10:00 pm, entre enero y febrero del 2021, donde se identificaron 2061 anuncios de alimentos y bebidas procesados. Entre 2:00 pm y 6:00 pm (33,9%) hubo mayor publicidad de alimentos. Las categorías más publicitadas fueron bebidas (41,7%) y confitería (17,8%). El 46,9% de alimentos superó al menos uno de los parámetros técnicos (azúcar total, grasas saturadas o sodio) de la primera etapa de la ley peruana y el 88,4% lo haría en la segunda etapa. La mayoría de alimentos y bebidas publicitados fueron procesados y superaban los parámetros de nutrientes críticos.Acceso abierto
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¿Herniorrafía con la técnica de Lichtenstein versus Nyhus? Una valoración crítica al diseño metodológico(Colegio Medico del Peru, 2017-03-10)"En primer lugar, los autores presentan el estudio como uno transversal cuando realmente es una cohorte retrospectiva. Al menos tres características respaldan mi argumento: la población de interés es seguida a lo largo de un periodo de tiempo, al inicio del seguimiento no tienen el outcome de interés (complicaciones) y un objetivo es estimar la incidencia del desenlace. En este estudio se ha estimado la magnitud del outcome (complicaciones tempranas y tardías post-operatorias) hasta los dos años de seguimiento en una población en base a registros clínico."Acceso abierto
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Manejo nutricional en un paciente pediátrico con Parálisis Cerebral Infantil, neumonía, síndrome obstructivo bronquial y retardo severo en el crecimiento(Renut, 2017-01-01)Paciente de sexo femenino con 3 años 3 meses de edad del servicio de Medicina Pediátrica I del Hospital Nacional Daniel A. Sánchez Carrión (HNDAC). Nacido de 38 semanas por cesaria, debido a que la madre presento peeclamsia en el ultimo trimestre de embarazo, la madre era primigesta. Neonato nace con parálisis cerebral infantil por causas prenatales. El diagnóstico médico a la evaluación fue de parálisis cerebral infantil(PCI), neumonía, síndrome obstructivo bronquial agudo(SOBA) y retardo severo en el crecimiento; como antecedentes patológicos la paciente presenta infecciones del tracto urinario (ITU)recurrentes, infecciones respiratorias persistentes y una ingesta deficiente de nutrientes.Acceso abierto
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Malnutrición por exceso y evolución clínica en niños menores de dos años, hospitalizados por infección respiratoria aguda baja(ARAN Ediciones, 2020-01-01)Acceso abierto
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Evaluación del efecto de las pérdidas de seguimiento de una cohorte de niños menores de 1 año de edad en Huanca- velica y Loreto, Perú(2020-01-01)"Objetivo: evaluar el efecto de las pérdidas durante el seguimiento de los participantes del estudio “Factores asociados a la desnutrición crónica en una cohorte de niños de establecimientos de salud públicos en las regiones Huancavelica y Loreto”. Materiales y métodos: la cohorte fue desarrollada para identificar las causas de la desnutrición crónica infantil en Huancavelica y Loreto, se evaluó a los niños a los 3, 6 ,9 y 12 meses de edad. Se enroló a niños nacidos en establecimientos de salud de ambas regiones. Se recolectó información sobre aspectos sociodemográficos, seguridad alimentaria consumo alimentario, antropometría y hemoglobina en cada etapa de evaluación. Se empleó un modelo en panel de regresión lineal múltiple, como variable dependiente la puntuación Z de talla para la edad de los participantes y como variable independiente las pérdidas de seguimiento. Resultados: se enroló a 1508 niños (748 en Huancavelica y 760 en Loreto), las pérdidas de seguimiento representaron el 39,7% y 26,4% en Huancavelica y Loreto respectivamente. Durante el enrolamiento hubo mayor prevalencia de desnutrición crónica infantil en Huancavelica (11,8%) que en Loreto (7,7%) (Valor de p= 0,001). Las pérdidas de seguimiento no afectaron la puntuación Z de talla para la edad (valor de p=0,461 IC: -0,18; 0,08). Conclusiones: el estudio de cohorte tuvo pérdidas de seguimiento dentro de lo estimado. Las pérdidas de seguimiento no afectaron el indicador relacionado con la desnutrición crónica infantil."Acceso abierto
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Factores sociodemográficos y nutricionales asociados a anemia en niños de 1 a 5 años en Perú(SciELO Agencia Nacional de Investigacion y Desarrollo (ANID), 2020-12-01)"Objetivo: Determinar los factores sociodemográficos y nutricionales asociados a la anemia en niños de 1 a 5 años de Perú según la Encuesta Nacional Demográfica y de Salud Familiar (DHS, por sus siglas en inglés Demographic and Health Survey). Metodología: Para determinar los posibles factores sociodemográficos y nutricionales asociados a la anemia, se hizo un subanálisis de la DHS 2017, tomando en cuenta un intervalo de confianza del 95% y considerando los parámetros de complejidad de la encuesta. Se describieron las frecuencias relativas en el análisis univariado. Para el análisis bivariado se empleó el test de chi cuadrado para las variables categóricas y t-Student para las variables continuas. Para el modelo de regresión múltiple, se realizó una regresión de Poisson cruda y ajustada con el método de selección de variables tipo backward. Principales resultados: La prevalencia de anemia fue de 38.5%. Los factores independientemente asociados fueron quintil de riqueza bajo (RP(a): 1,23; IC95%: 1,0-1,4), ningún grado de instrucción o grado de instrucción primaria de la madre (RP(a): 1,25; IC95%: 1,0-1,5), edad de la madre menor de 19 años (RP(a): 1,34; IC95%: 1,1-1,7), lugar del parto no institucionalizado (RP(a): 1,24; IC95%: 1,1-1,5), no consumo de antiparasitarios (RP(a): 1,13; IC95%:1,0-1,3) y altitud mayor o igual a 4000 msnm (RP(a): 1,45; IC95%: 1,2-1,8). Conclusiones: La prevalencia de anemia en niños de 1 a 5 años en el 2017 fue moderada. Existen factores sociodemográficos y nutricionales asociados a dicha condición."Acceso abierto
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Association between adherence to the Mediterranean diet and self-reported oral manifestations in older adults.(Sociedad Espanola de Nutricion Comunitaria, 2024-01-01)Background: The Mediterranean Diet is very abundant in vitamins that could contribute to the balance in the maintenance of oral cavity health. Therefore, it is necessary to determine the association of adherence to the Mediterranean diet with self-reported oral manifestations in older adults. Methods: The study design was observational, analytical and cross-sectional. It was carried out through a virtual survey in older adults during the year 2022. Validated instruments of adherence to the Mediterranean diet (MEDAS-14) and a self-report on oral manifestations were used, in addition various covariates were evaluated. For the qualitative variables, relative and absolute frequencies were obtained. In the bivariate analysis, the Chi-square statistical test was used. For the association of the qualitative variables and the calculation of the raw and adjusted prevalence ratios, Poisson regression with robust variance was used. Result: It was found that 90.91% of the respondents who maintained a high adherence to the MD did not manifest halitosis. In addition, it was observed that 57.58% who followed a high Mediterranean diet did not manifest dental pain. In the multivariate analysis, a statistically significant association was found between those surveyed who adhered to the MD with certain oral manifestations such as the presence of dental caries, dental pain, halitosis, presence of bleeding, and dental mobility in the crude and adjusted analyzes. Conclusions: Adherence to the Mediterranean diet is related to better health status in an older adult population.Acceso restringido temporalmente
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Perception of the virtual learning environment and social presence in Physiotherapy students during the COVID-19 pandemicIntroduction: the aim of this study was to determine the association between the perception of the virtual learning environment and the social presence in Physiotherapy students during the COVID-19 pandemic. Material and method: the design was observational, cross-sectional and analytical. The perception of the virtual learning environment and social presence were measured through the Spanish version of the Distance Learning Education Environments Survey and Networked Minds Social Presence Measure questionnaires, respectively. The survey was sent to 223 students, but only 65 entered the research. Results: it was found that 76.9 % had regular internet quality, 84.6 % used a laptop as the main technological device for the study and 72.3 % indicated that the use of the device was exclusive. Regarding the virtual learning environment, the constructs «Active learning»(4.1 ± 0.6) and «Autonomy» (4.1 ± 0.6) obtained high scores; while, for social presence, the constructs «Co-presence» (5.4 ± 1.0) and «Perceived understanding of the message» (5.0 ± 0.9). In addition, it was found that «Teacher support» (r = 0.41, p < 0.001) and «Personal relevance» (r = 0.37, p = 0.002) were associated with social presence. Conclusion: an association was found between the perception of teacher support and personal relevance in the virtual learning environment and social presence in Physiotherapy students during the COVID-19 pandemic.Acceso restringido temporalmente
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Characteristics of COVID-19 mortality during and after the pandemic in Peru(Universidad Nacional Mayor de San Marcos, Facultad de Medicina, 2024-01-01)Introduction. The COVID-19 emergency caused a pandemic with a great impact on mortality in Peru. Objective. To analyze the magnitude of mortality due to COVID-19 and identify some sociodemographic characteristics. Methods. A descriptive ecological study was carried out, analyzing data on deaths due to COVID-19 during the period 2020-2023, as well as publicly accessible socioeconomic and demographic indicators. The variables included in the study were: year of death, number of deaths, sex, age group, province of origin, natural region, macroregion, human development index (HDI), unmet basic needs (UBN) and population density. Results. 220,628 deaths due to COVID-19 were reported, of which 219,374 (99.43%) occurred during the pandemic and 1,254 (0.57%) in the post-pandemic period; The cumulative mortality rate was 6.76 deaths/1000 inhabitants. The COVID-19 death curve shows that between 2020-2023, five waves occurred, with the second wave having the highest mortality, followed by the first wave. Mortality predominated in men, older adults (69.77%) and adults (28.11%). The macroregion of Metropolitan Lima and Callao had the highest mortality rates with 9.36 deaths/1000 inhabitants. The provinces with the highest cumulative mortality rates were those located on the coast, in quintiles with less NBI, in quintiles with a higher HDI and in those provinces with a higher population density. Conclusions. The COVID-19 pandemic caused high mortality in Peru, being higher in males, older adults, from coastal cities, with higher population density and better socioeconomic indicators.Acceso restringido temporalmente
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Core needle biopsy of breast tumours: comparison of diagnostic performance between surgery and radiology services at a national cancer centre in Latin America(ecancer Global Foundation, 2024-01-01)Introduction: Breast pathology is a very common reason for medical attention. Tissue diagnosis is usually obtained with core needle biopsy which could be performed by breast surgeons or interventional radiologists. Our aim was to assess the comparison of diagnostic performance between the two services. Methods: A retrospective, descriptive and cross-sectional study was carried out on patients who had breast pathology at Instituto Nacional de Enfermedades Neoplasicas in 2019. Descriptive analyses, sensitivity and specificity were calculated using the R program version 4.2.3. Results: From 1,082 patients with breast tumours who underwent core needle biopsy (CNB) during 2019, 782 cases were included. Breast surgeons performed 462 CNBs and radiologists performed 320 CNBs. The 87.5% were palpable tumours and 525 breast carcinomas were identified in the final pathology. The diagnostic performance showed that the sensitivity and specificity were greater than 95% and 98%, respectively. The waiting time in both showed that >95% underwent a CNB before 2 months. The breast surgery service performed the majority of the biopsies in less than 1 week since the indication of the execution of the CNB compared to the radiology service (90% versus 36%). Conclusion: Both hospital services, breast surgery and radiology, are efficient in determining an accurate diagnosis using CNB. However, the breast surgery service performs CNB in a shorter time interval. Breast surgical oncologists are encouraged to perform CNB if there are understaffed radiology services to expedite the diagnosis and treatment of breast cancer patients.Acceso abierto
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Telomere length in subjects with and without SARS-CoV-2 infection: a systematic review and meta-analysis(Associacao Medica Brasileira, 2024-01-01)Acceso abierto
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Homocysteine, vitamin B12, and folate circulating levels in women with and without polycystic ovary syndrome: A systematic review and meta-analysis(SAGE Publications Ltd, 2024-01-01)Background: Some studies have reported that homocysteine, vitamin B12, and folic acid levels are associated with polycystic ovary syndrome (PCOS), whereas other studies yielded controversial results. Objectives: This study aimed to systematize the available evidence of homocysteine, vitamin B12, and folate levels in women with and without PCOS. Design: Systematic review and meta-analysis Data Sources and Methods: A systematic search without language restrictions was performed on PubMed, Ovid/Medline, Scopus, Embase, and Web of Science. In addition, the reference lists of the selected studies were reviewed. The Newcastle–Ottawa Scale was employed to evaluate the quality of studies. The means and standard deviations of the outcomes were pooled as standardized mean differences (SMDs) with 95% confidence intervals (CI). Furthermore, the DerSimonian and Laird method was employed for the quantitative synthesis. Results: A total of 75 studies met the eligibility criteria for at least one outcome. Patients with PCOS had higher circulating homocysteine levels than those without (SMD: 0.82; 95% CI: 0.62–1.02, n = 70 studies, p < 0.001). This trend remained in the sensitivity and subgroup analyses by world regions of studies, assay methods, and insulin resistance. No significant differences were observed in circulating vitamin B12 (SMD: −0.11; 95% CI: −0.25 to 0.03; n = 17 studies, p = 0.13) and folate levels (SMD: −0.2; 95% CI: −0.68 to 0.27; n = 17 studies, p = 0.41) between patients with and without PCOS. Conclusions: (i) Patients with PCOS exhibited significantly higher homocysteine levels than those without, and (ii) no significant differences were observed in both vitamin B12 and folate levels in women with and without PCOS. Registration: PROSPERO ID (CRD42023432883)Acceso abierto
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Burkholderia cepacia cervical spondylodiscitis in a 39-year-old immunocompetent woman after a rhinoplasty: A case report and review of literature(Scientific Scholar, 2024-01-01)Background: Burkholderia cepacia has been described as a rare etiology for spondylodiscitis (SD) after surgical procedures. Case Description: We report a rare case of cervical SD caused by B. cepacia in a 39-year-old immunocompetent woman after a rhinoplasty treated with complex cervical surgery and prolonged antibiotic therapy. The follow-up visits showed no recurrence of symptoms. Conclusion: Diagnostic and therapeutic of rare spinal infections, particularly those caused by atypical pathogens such as B. cepacia, are challenging. Identification and personalized therapy are crucial.Acceso restringido temporalmente
