Now showing items 1-20 of 952

    • Extrinsic motivation: Determining factor in the medicine career?

      Sanchez Pimentel, Janett Isabel; Rosario Pacahuala, Emilio Augusto; Medina Gamero, Aldo Rafael (Elsevier Espana S.L.U, 2020-01-01)
      Carta al editor
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    • Submandibular hemangioma with cardiorespiratory arrest in an infant

      Arriola-Montenegro, Jose; Guerra-Canchari, Pedro; Cabanillas-Lozada, Patricia; Contreras-Chavez, Pamela; Arriola-Montenegro, Liliana; Ordaya-Gonzales, Karina; Sabogal-Deza, Marilin (Iranian Pediatric Hematology and Oncology Society, 2020-01-01)
      Hemangiomas are defined as soft tissue lesions in the maxillofacial or oral region. Hemangiomas of salivary glands constitute 30% of the non-epithelial tumors in major salivary glands. Benign tumors in salivary glands are located 85% in parotid gland and 13% in submandibular gland. We present a case of submandibular hemangioma in an infant patient that had some complications and a challenging diagnosis. A 3-month-old female patient presented a giant hemangioma located in the submandibular, preauricular and right malar region with purplish color that during hospitalization had a cardiorespiratory arrest as a severe complication of the disease.
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    • Von Hippel-Lindau disease with extramedullary and pancreatic involvement

      Pantigozo-Rimachi, Andrea; Murillo-Díaz, Giuliana; Carreazo, Nilton Yhuri; Cucho Dávila, Victor Manuel (Elsevier B.V., 2020-01-01)
      We report a patient with Von Hippel-Lindau disease who presented with an intradural extramedullary hemangioblastoma as a primary manifestation.
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    • Rheological, mineralogical and strength variability of concrete due to construction water impurities

      Awoyera, Paul O.; Awobayikun, Oyinkansola; Gobinath, Ravindran; Viloria, Amelec; Ugwu, Emmanuel I. (Trans Tech Publications Ltd, 2020-01-01)
      Various national and international standards recommend potable water for mixing concrete; however, the availability of potable water is virtually a daunting task in some developing communities. Concrete workers in such environments tend to utilize any available water for mixing concrete, and this may be detrimental to the quality of the concrete being produced. This study investigates the rheological, mineralogical and strength variability of concrete due to construction water impurities. Water samples were collected from four different construction sites within Southwestern region of Nigeria for production of concrete. The physical and chemical properties of the waters were determined so as to measure their rate of contamination, prior to their use for mixing concrete. The rheological properties of the fresh concrete, compressive strength, split tensile strength, and microscale features of hardened concrete, that were produced with each water sample were determined. From the results, the rheological features of concrete were found not to be affected by water impurities, however, the mechanical test results revealed about 10% reduction in strength between concrete made with water having least and higher concentration of impurities. Also, it was evident from the microscale tests that the water impurities do alter the hydration rate of concrete, which results in strength reduction. The study suggests pretreatment of concrete mixing water before use in order to avoid its damaging effect on concrete life.
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    • Factors associated with the severity of pruritus in patients with terminal chronic kidney disease undergoing hemodialysis in Lima, Peru

      Kossuth-Cabrejos, Stefano; Gavino-Gutiérrez, Arquímedes M.; Silva-Caso, Wilmer (Page Press Publications, 2020-01-01)
      The objective of the study is to analyze the factors associated with the severity of pruritus in patients with terminal chronic kidney disease undergoing hemodialysis. The methodology used is based on a cross-sectional study in patients receiving hemodialysis at the Centro Nacional de Salud Renal. Severe pruritus was defined as a score on the visual analogue scale greater than or equal to 7, and the strength of association with the possible risk factors was assessed by calculating prevalence ratios. Regarding the results, 264 patients were included, 59.9% were male, with a mean time on hemodialysis of 10.26 ± 7.14 years. 75% experienced pruritus, of this group, 1 in 3 presented severe pruritus. Hyperphosphatemia and the use of antihistamines were associated with a higher prevalence of severe pruritus (RP 1.71, 95% CI 1.09-267 and RP 2.39, 95% CI 1.51-3.75, respectively). The positive serology for Hepatitis C Virus was described as a protective factor for presenting severe pruritus (RP 0.55, 95% CI 0.33 - 0.89). In conclusion, severe uremic pruritus is a frequent problem in patients with chronic terminal kidney disease who have hyperphosphatemia and treatment with antihistamines independently of the time they have been on hemodialysis.
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    • Psychometric properties of the olson and barnes quality of life scale in lima students

      Grimaldo, Mirian Pilar; Correa, Jossué David; Jara, Diego; Cirilo, Ingrid Belu; Aguirre, Marivel Teresa (Instituto de Investigacion de Drogodependencias, 2020-01-01)
      Quality of life refers to the way in which the person perceives their daily experience, considering in this process the social and cultural component. This implies that to know the perception of the quality of life it is necessary to consider in its measurement the scope of physical, psychological, social, environmental and personal health. Along these lines, one of the instruments that is limited to this approach is the Barnes and Olson Quality of Life Scale (ECVOB). Objective. The purpose of the study was to determine the validity based on the internal structure and reliability of the ECVOB in schoolchildren and university students in Lima. Method. The study design is instrumental. The Spanish version of the ECVOB was used on a sample of 1239 students from Lima between males (57%) and females (43%) aged between 14 and 26 years (M age = 22.45; SD age = 3.75). The evidence of validity of the internal structure was evaluated through a confirmatory factor analysis. Results. The findings suggest a partial restructuring of the original seven-factor model proposed by Olson and Barnes. Conclusion. The new structure of the ECVOB is a valid and reliable measure in schoolchildren and university students in Lima.
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    • Prevalence of Diabetes Mellitus and Its Associated Unfavorable Outcomes in Patients With Acute Respiratory Syndromes Due to Coronaviruses Infection: A Systematic Review and Meta-Analysis

      Pinedo-Torres, Isabel; Flores-Fernández, Magaly; Yovera-Aldana, Marlon; Gutierrez-Ortiz, Claudia; Zegarra-Lizana, Paolo; Intimayta-Escalante, Claudio; Moran-Mariños, Cristian; Alva-Diaz, Carlos; Pacheco-Barrios, Kevin (SAGE Publications Ltd, 2020-01-01)
      Introduction: Only 3 types of coronavirus cause aggressive respiratory disease in humans (MERS-Cov, SARS-Cov-1, and SARS-Cov-2). It has been reported higher infection rates and severe manifestations (ICU admission, need for mechanical ventilation, and death) in patients with comorbidities such as diabetes mellitus (DM). For this reason, this study aimed to determine the prevalence of diabetes comorbidity and its associated unfavorable health outcomes in patients with acute respiratory syndromes for coronavirus disease according to virus types. Methods: Systematic review of literature in Pubmed/Medline, Scopus, Web of Science, Cochrane, and Scielo until April of 2020. We included cohort and cross-sectional studies with no restriction by language or geographical zone. The selection and extraction were undertaken by 2 reviewers, independently. The study quality was evaluated with Loney’s instrument and data were synthesized by random effects model meta-analysis. The heterogeneity was quantified using an I2 statistic. Funnel plot, Egger, and Begg tests were used to evaluate publication biases, and subgroups and sensitivity analyses were performed. Finally, we used the GRADE approach to assess the evidence certainty (PROSPERO: CRD42020178049). Results: We conducted the pooled analysis of 28 studies (n = 5960). The prevalence analysis according to virus type were 451.9 diabetes cases per 1000 infected patients (95% CI: 356.74-548.78; I2 = 89.71%) in MERS-Cov; 90.38 per 1000 (95% CI: 67.17-118.38) in SARS-Cov-1; and 100.42 per 1000 (95% CI: 77.85, 125.26 I2 = 67.94%) in SARS-Cov-2. The mortality rate were 36%, 6%, 10% and for MERS-Cov, SARS-Cov-1, and SARS-Cov-2, respectively. Due to the high risk of bias (75% of studies had very low quality), high heterogeneity (I2 higher than 60%), and publication bias (for MERS-Cov studies), we down rate the certainty to very low. Conclusion: The prevalence of DM in patients with acute respiratory syndrome due to coronaviruses is high, predominantly with MERS-Cov infection. The unfavorable health outcomes are frequent in this subset of patients. Well-powered and population-based studies are needed, including detailed DM clinical profile (such as glycemic control, DM complications, and treatment regimens), comorbidities, and SARS-Cov-2 evolution to reevaluate the worldwide prevalence of this comorbidity and to typify clinical phenotypes with differential risk within the subpopulation of DM patients.
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    • Physical activity levels by glycemia status: A population-based cross-sectional study in Peru

      Ganoza-Calero, Antonelhla M.; Cuadros-Torres, Milagros; Bernabé-Ortiz, Antonio (Elsevier Ltd, 2021-04-01)
      Objective: To assess whether the prevalence of low physical activity levels and time spent watching TV differ depending on glycemia status. Methods: A secondary analysis using data from a population-based study was conducted. Two were the outcomes: physical activity levels, derived from the International Physical Activity Questionnaire, and sitting time watching TV. The exposure was glycemia status, defined based on results of the oral glucose tolerance tests (OGTT): euglycemia, dysglycemia, and T2DM. The T2DM group was further split into: aware and unaware of T2DM diagnosis. Prevalence ratios (PR) and 95% CI were reported using Poisson regression models. Results: Data of 1607 individuals, mean age 48.2 (SD: 10.6) years, 809 (50.3%) females, were analyzed. Dysglycemia and T2DM was present in 16.9% (95% CI: 15.1%–18.8%) and 11.0% (95% CI: 9.5%–12.6%) of participants, respectively. A total of 605 (37.6%; 95% CI: 35.2%–39.9%) participants had low levels of physical activity and 1019 (63.3%; 95% CI: 60.9%–65.7%) subjects spent ≥2 h per day sitting watching TV. In multivariable model, there was no significant association between glycemia status and physical activity levels (PR = 1.14; 95% CI: 0.95–1.36). Similar result was found between glycemia status and sitting time watching TV. However, those aware of T2DM diagnosis were more likely to have low levels of physical activity (PR = 1.31; 95% CI: 1.06–1.61) compared to the euglycemia group. Conclusions: We found a no relationship between glycemia status and physical activity level or sitting time watching TV, pointing out similar levels of physical (in)activity among those with euglycemia, dysglycemia and T2DM. Individuals aware of having T2DM were 30% more likely to have low physical activity levels compared to the euglycemic group. There is a need to increase physical activity levels among T2DM individuals.
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    • Carvacrol: An in silico approach of a candidate drug on HER2, PI3Kα, mTOR, HER-α, PR, and EGFR receptors in the breast cancer

      Herrera-Calderon, Oscar; Yepes-Pérez, Andres F.; Quintero-Saumeth, Jorge; Rojas-Armas, Juan Pedro; Palomino-Pacheco, Miriam; Ortiz-Sánchez, José Manuel; Cieza-Macedo, Edwin César; Arroyo-Acevedo, Jorge Luis; Figueroa-Salvador, Linder; Peña-Rojas, Gilmar; Andía-Ayme, Vidalina (Hindawi Limited, 2020-01-01)
      Carvacrol is a phenol monoterpene found in aromatic plants specially in Lamiaceae family, which has been evaluated in an experimental model of breast cancer. However, any proposed mechanism based on its antitumor effect has not been reported. In our previous study, carvacrol showed a protective effect on 7,12-dimethylbenz[α]anthracene- (DMBA-) induced breast cancer in female rats. The main objective in this research was to evaluate by using in silico study the carvacrol on HER2, PI3Kα, mTOR, hERα, PR, and EGFR receptors involved in breast cancer progression by docking analysis, molecular dynamic, and drug-likeness evaluation. A multilevel computational study to evaluate the antitumor potential of carvacrol focusing on the main targets involved in the breast cancer was carried out. The in silico study starts with protein-ligand docking of carvacrol followed by ligand pathway calculations, molecular dynamic simulations, and molecular mechanics energies combined with the Poisson–Boltzmann (MM/PBSA) calculation of the free energy of binding for carvacrol. As result, the in silico study led to the identification of carvacrol with strong binding affinity on mTOR receptor. Additionally, in silico drug-likeness index for carvacrol showed a good predicted therapeutic profile of druggability. Our findings suggest that mTOR signaling pathway could be responsible for its preventive effect in the breast cancer.
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    • Validity and invariance of measurement of the satisfaction with love life scale in older adults

      Caycho-Rodríguez, Tomás; Sancho, Patricia; Tomás, José M.; Esteban, Renzo Felipe Carranza; Ventura-León, José; Neto, Felix; Reyes-Bossio, Mario; Cabrera-Orosco, Isabel (South-West University "Neofit Rilski", 2020-01-01)
      In recent years, interest in satisfaction with love life (SWLL) has increased. Empirical evidence demonstrated that SWLL favors subjective well-being, physical and mental health, marital quality and stability. In this regard, the study aimed to examine evidence based on the internal structure validity, reliability, and measurement invariance of the Peruvian version of the Satisfaction with Love Life Scale (SWLLS). The participants were 323 older adults recruited from the region of San Martin (Peru) with an average age of 68.73 years (SD = 7.17). The sample comprised of 49.5% women and 50.5% men. The results supported the one-dimensional model and adequate reliability of the SWLLS. A multi-group analysis provided evidence of configural, metric, and scale invariance across genders. The findings verified the validity and reliability of the Peruvian version of the SWLLS, which can be used to measure SWLL.
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    • Social networks and condomless intercourse with female partners among male sex workers in the Dominican Republic

      Saiyed, Faiez K.; Segura, Eddy R.; Tan, Diane; Clark, Jesse L.; Lake, Jordan E.; Holloway, Ian W. (SAGE Publications Ltd, 2021-02-01)
      Male sex workers (MSW) in the Dominican Republic (DR) have multiple sexual partners, including personal and client-relationships, and are disproportionately affected by human immunodeficiency virus (HIV). We examined the prevalence of condomless anal and/or vaginal intercourse (CI) among MSW in the DR as a function of social network factors. Self-report surveys and social network interviews were administered to MSW recruited through venue-based sampling (N = 220). A generalized linear model was used to complete a Poisson Regression model and identify variables significantly associated with the outcome of interest. CI was more common with female (28.3%) than with male partners (4.9%). Factors associated with CI with the last female partner included older age of MSW, CI with the last male partner, having a stable female partner (a consistent or main partner), and having ≥1 family member in the participants’ social network. Partner and social network characteristics associated with CI among MSW suggest the utility of dyadic and network interventions to reduce HIV risk.
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    • Cultural adaptation and validation of SATAQ-4 “Sociocultural attitudes towards appearance questionnaire-4” for peruvian population

      Zevallos-Delzo, Carolina; Maguiña, Jorge L.; Catacora, Manuel; Mayta-Tristán, Percy (Sociedad de Neurologia Psiquiatria y Neurocirugia, 2020-03-01)
      Introduction: Eating disorders (anorexia and bulimia) have been increasing worldwide and nationally. Prior to the development of this disorder, adolescents' present body dissatisfaction, whose study through the ¨Tripartite Influence Model¨ gives us three main pressures: Pressure from parents, media and peers. Factors that are studied through SATAQ-4. We conduct a study to validate the Peruvian version of SATAQ-4 "Sociocultural Attitudes Toward Appearance Questionnaire-4". Methods: A cross-sectional study was carried out in 2015. It was started by culturally adapting the test. Subsequently, validity was determined through the validity of the construct, and reliability through internal consistency assessment and intra-observer reliability (test-retest). Results: We obtained a culturally adapted instrument which presented a mean greater than 3 in the Delphi method, an intraclass correlation equal to 0.83 and an internal consistency (Cronbach alpha) of 0.90. The confirmatory factor analysis supported the original five-factor structure and the convergent validity analysis (r Pearson) when compared with BSQ a correlation of 0.70. Conclusions: The instrument adequately measures the construct for which it was created and can be applied in the Peruvian university environment.
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    • Ameliorative Effect of the Oral Administration of Chuquiraga spinosa in a Murine Model of Breast Cancer Induced with 7,12-Dimethylbenz[a]anthracene (DMBA)

      Arroyo-Acevedo, Jorge Luis; Herrera-Calderon, Oscar; Tinco-Jayo, Johnny Aldo; Rojas-Armas, Juan Pedro; Rauf, Abdur; Hañari-Quispe, Renán; Figueroa-Salvador, Linder; Fernández-Guzmán, Victor; Yuli-Posadas, Ricardo Ángel (EManuscript Technologies, 2020-05-01)
      Objective: To determine the ameliorative effect of the ethanolic extract of Chuquiraga spinosa (ChS) on 7,12-Dimethylbenz[a]anthracene (DMBA)-induced breast cancer in rats. Methods: 36 female Holztman rats were divided into 6 groups. I) The negative control group received physiological saline (PS). II) ChS-200 group received 200 mg/kg of ChS. III) DMBA group was induced with DMBA (20 mg/Kg) dissolved in PS and administrated orally for 15 weeks. IV) DMBA + ChS-50 group, V) DMBA + ChS-250 group, and VI) DMBA + ChS-500 group, which received the extract orally for 15 weeks after DMBA induction. All data were expressed as mean and standard deviation. One-way analysis of variance (ANOVA) followed by Dunnet test was carried out to compare the mean value of different groups Histopathological analysis was evaluated by using Image J software. Results: Hematology showed that the triglyceride level was significantly lowered (P< 0.01) and high-density lipoprotein (HDL) level was significantly increased (P <0.01) in groups III, IV and V. Also, ChS extract significantly lowered the C reactive protein (CRP) level (P <0.01) and malondialdehyde level (P<0.05). There was a significant decrease in the frequency of DMBA-induced micronucleated polychromatic erythrocyte (P<0.01). Conclusions: Chuquiraga spinosa showed an ameliorative effect on DMBA-induced breast cancer in rats as well as antioxidant, antitumor and antigenotoxic properties.
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    • Association between Maternal Depressive Symptoms with Overweight/Obesity among Children Aged 0-5 Years According to the 2016 Demographic and Family Health Survey

      Echevarría-Castro, Nataly; Matayoshi-Pérez, Andrea; Alvarado, Germán F. (Mary Ann Liebert Inc., 2020-07-01)
      Background: Overweight and obesity among children under the age of 5 have become a public health problem. The worldwide prevalence is 4.9% and 6.0%, whereas in Peru it is 7.4% and 1.9%, respectively. The causes of these problems are multifactorial and must be studied to prevent the multiple consequences on children's health. Methods: Secondary data analysis of the 2016 Demographic and Family Health Survey (DHS). The sample size was 7935 children and their mothers. The dependent variable was childhood overweight/obesity, measured according to the Z-score of the BMI >2 standard deviation (SD), while the main independent variable consisted of the maternal depressive symptoms (DS) (Patient Health Questionnaire-9 score >10 points). The software STATA/MP 14.0 was used for statistical analysis. Results: The prevalence of overweight/obesity among children aged 0-5 years was 4.5% and the prevalence of moderate and severe maternal DS was 7.1%. No maternal depressive symptoms were found to be associated with the outcome [adjusted PR = 1.36 95% confidence interval (CI) = 0.59-3.09 p = 0.47]. An association was found between socioeconomic status (SES) Q3 (adjusted PR = 3.86 95% CI = 1.9-7.6 p < 0.0001), Q4 (adjusted PR = 5.53 95% CI = 2.76-11.1 p < 0.0001), Q5 (adjusted PR = 6.9 95% CI = 3.24-14.7 p = < 0.0001), maternal BMI (adjusted PR = 1.06 95% CI = 1.03-1.08 p < 0.0001), and cesarean delivery (adjusted PR = 1.42 95% CI = 1.01-1.99 p = 0.042). Conclusions: No association was found between maternal depressive symptoms and overweight/obesity among children aged 0-5 years. The upper SES quintiles, maternal BMI, and cesarean delivery were associated with the outcome.
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    • Spanish translation and validation of a brief measure of anxiety by the COVID-19 in students of health sciences

      Caycho-Rodríguez, Tomás; Barboza-Palomino, Miguel; Ventura-León, José; Carbajal-León, Carlos; Noé-Grijalva, Martín; Gallegos, Miguel; Reyes-Bossio, Mario; Vivanco-Vidal, Andrea (Elsevier Espana S.L.U, 2020-07-01)
      Introduction and objectives: COVID-19 has generated negative consequences for people's mental health. This is the case of Peru, one of the Latin American countries most affected by the pandemic. In this sense, the objective of the study was to translate and validate the Coronavirus Anxiety Scale (CAS) into Spanish. Material and method: The participants were 704 university students of health sciences (Mage = 23.39 years, SD = 3.45) who were administered the CAS in Spanish, the Mental Health Inventory-5 and the Patient Health Questionnaire-2 item. The CAS was translated into Spanish using the forward and backward method. Reliability and evidence of validity based on internal structure and relationship with other variables were examined. Results: The factor analysis confirmed the one-dimensional factor structure of the CAS (χ2 = 7.62, df = 5, p = .18, χ2 / gl = 1.52, CFI = .99, RMSEA = .03 [90% CI. 00,. 06]; SRMR = .02, WRMR = .52); In addition, the factor loadings were large and significant (from. 68 to. 87). The five CAS items showed acceptable corrected total test item correlations (from. 64 to. 74). Reliability due to internal consistency was good (ω = .89; αordinal = .89). The validity evidence based on the relationship with other CAS variables was supported by the positive correlation with depression (r = .52, p < .01) and negative with subjective well-being (r = -.50, p < .01). Furthermore, depression mediates the relationship between COVID-19 anxiety and subjective well-being (bootstrap value = -. 24, 95% CI = -. 28, -. 20). Conclusion: The Spanish version of the CAS has evidence of validity and reliability to measure anxiety by COVID-19 in a sample of Peruvian university students.
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    • Endoscopic ultrasound-guided injection of coils for the treatment of refractory post-ERCP bleeding

      Guzmán-Calderón, Edson; Ruiz, Francisco; Casellas, Juan Antonio; Martinez-Sempere, Juan; Medina-Prado, Lucía; Aparicio, Jose R. (Georg Thieme Verlag, 2020-08-01)
      No presenta resumen.
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    • Association of statin use and clinical outcomes in heart failure patients: A systematic review and meta-analysis

      Bielecka-Dabrowa, Agata; Bytyçi, Ibadete; Von Haehling, Stephan; Anker, Stefan; Jozwiak, Jacek; Rysz, Jacek; Hernandez, Adrian V.; Bajraktari, Gani; Mikhalidis, Dimitri P.; Banach, Maciej (BioMed Central Ltd, 2019-10-31)
      Background The role of statins in patients with heart failure (HF) of different levels of left ventricular ejection fraction (LVEF) remains unclear especially in the light of the absence of prospective data from randomized controlled trials (RCTs) in non-ischemic HF, and taking into account potential statins’ prosarcopenic effects. We assessed the association of statin use with clinical outcomes in patients with HF. Methods We searched PubMed, EMBASE, Scopus, Google Scholar and Cochrane Central until August 2018 for RCTs and prospective cohorts comparing clinical outcomes with statin vs non-statin use in patients with HF at different LVEF levels. We followed the guidelines of the 2009 PRISMA statement for reporting and applied independent extraction by multiple observers. Meta-analyses of hazard ratios (HRs) of effects of statins on clinical outcomes used generic inverse variance method and random model effects. Clinical outcomes were all-cause mortality, cardiovascular (CV) mortality and CV hospitalization. Results Finally we included 17 studies (n = 88,100; 2 RCTs and 15 cohorts) comparing statin vs non-statin users (mean follow-up 36 months). Compared with non-statin use, statin use was associated with lower risk of all-cause mortality (HR 0.77, 95% confidence interval [CI], 0.72–0.83, P < 0.0001, I2 = 63%), CV mortality (HR 0.82, 95% CI: 0.76–0.88, P < 0.0001, I2 = 63%), and CV hospitalization (HR 0.78, 95% CI: 0.69–0.89, P = 0.0003, I2 = 36%). All-cause mortality was reduced on statin therapy in HF with both EF < 40% and ≥ 40% (HR: 0.77, 95% Cl: 0.68–0.86, P < 0.00001, and HR 0.75, 95% CI: 0.69–0.82, P < 0.00001, respectively). Similarly, CV mortality (HR 0.86, 95% CI: 0.79–0.93, P = 0.0003, and HR 0.83, 95% CI: 0.77–0.90, P < 0.00001, respectively), and CV hospitalizations (HR 0.80 95% CI: 0.64–0.99, P = 0.04 and HR 0.76 95% CI: 0.61–0.93, P = 0.009, respectively) were reduced in these EF subgroups. Significant effects on all clinical outcomes were also found in cohort studies’ analyses; the effect was also larger and significant for lipophilic than hydrophilic statins. Conclusions In conclusion, statins may have a beneficial effect on CV outcomes irrespective of HF etiology and LVEF level. Lipophilic statins seem to be much more favorable for patients with heart failure.
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    • Pregnancy-Induced Hemophagocytic Lymphohistiocytosis: A Case Report

      Sánchez-Ato, Luis A.; Cuestas-Quiroz, Flavia A.; Agurto-Saldaña, Carla; Estela-Ayamamani, David (Springer, 2020-10-01)
      No presenta presenta resumen.
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    • Alsinol, an arylamino alcohol derivative active against Plasmodium, Babesia, Trypanosoma, and Leishmania: past and new outcomes

      Arias, Maria H.; Quiliano, Miguel; Bourgeade-Delmas, Sandra; Fabing, Isabelle; Chantal, Isabelle; Berthier, David; Minet, Cécile; Eparvier, Veronique; Sorres, Jonathan; Stien, Didier; Galiano, Silvia; Aldana, Ignacio; Valentin, Alexis; Garavito, Giovanny; Deharo, Eric (Springer Science and Business Media Deutschland GmbH, 2020-10-01)
      Malaria, babesiosis, trypanosomosis, and leishmaniasis are some of the most life-threatening parasites, but the range of drugs to treat them is limited. An effective, safe, and low-cost drug with a large activity spectrum is urgently needed. For this purpose, an aryl amino alcohol derivative called Alsinol was resynthesized, screened in silico, and tested against Plasmodium, Babesia, Trypanosoma, and Leishmania. In silico Alsinol follows the Lipinski and Ghose rules. In vitro it had schizontocidal activity against Plasmodium falciparum and was able to inhibit gametocytogenesis; it was particularly active against late gametocytes. In malaria-infected mice, it showed a dose-dependent activity similar to chloroquine. It demonstrated a similar level of activity to reference compounds against Babesia divergens, and against promastigotes, and amastigotes stages of Leishmania in vitro. It inhibited the in vitro growth of two African animal strains of Trypanosoma but was ineffective in vivo in our experimental conditions. It showed moderate toxicity in J774A1 and Vero cell models. The study demonstrated that Alsinol has a large spectrum of activity and is potentially affordable to produce. Nevertheless, challenges remain in the process of scaling up synthesis, creating a suitable clinical formulation, and determining the safety margin in preclinical models.
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    • Facial reconstruction according to aesthetic units

      Nunez Castaneda, José; Chang Grozo, Silvana (Wolters Kluwer Medknow Publications, 2020-10-01)
      Context: The facial subunit principle organizes the facial skin into subunits. Facial reconstruction for skin cancer based on aesthetic units consists of replacing the entire subunit when a large part of a subunit has been removed. Aims: To determine the prevalence of facial skin cancer, their location by facial aesthetic units, and the type of facial reconstruction used in each of them. Settings and Design: An observational cross-sectional study was conducted at the Head and Neck Surgery Service of a general hospital between 2017 and 2018. Materials and Methods: A population census was conducted during this period. Statistical Analysis Used: The categorical variables were expressed as frequencies (percentages). Continuous variables were described as the means and standard deviations or medians and interquartile ranges. Results: The most common skin cancer was basal cell skin cancer, followed by epithelial skin cancer and, at last, melanoma. In general, the most frequent localization of these cancers was the nose. Conclusions: In spite of primary closure being the most common form of reconstruction, a considerable number of patients required facial reconstruction based on aesthetic facial units, with satisfying results.
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