Factores asociados a sobrevida en pacientes con co-infección VIH-TB en el Servicio de Infectología del Hospital Nacional Arzobispo Loayza durante los años 2004-2012.

Abstract

The main cause of death in HIV patients is tuberculosis. However few Latin American studies have evaluated the prognosis of patients with co infection. Objective: To determine the factors associated with survival in patients with HIV-TBC co infection treated at the Department of Infectology of a Peruvian referral hospital during the years 2004-2012. Materials and Methods: A retrospective cohort study was performed based on clinical records of patients treated at the Department of Infectology in the Arzobispo Loayza National Hospital from 2004 to 2012. Survival was assessed using the Kaplan-Meier estimator and Cox Proportional Hazard Model. Results: From 315 patients, 82 died during the follow-up. The mean of follow for each patient was 730 days. The multivariate analysis showed that receiving HAART (HR: 0,31; IC: 0,20-0,50; P<0,01) and having more weight (HR: 0,96; IC 0,94–0,98; P<0,01) when the co infection if diagnosed, are protective factors; while having a pathology different from TBC (HR: 1,88; IC: 1,19-2,98; P<0,01), age in years (HR: 1,76; IC: 1,12-2,74; P≤0,01) and being hospitalized when diagnosed with TBC (HR: 1,69; IC 1,02-2,80; P<0,04)are associated with lower survival. Discussion: Receiving HAART and having more weight hen the co infection is diagnosed are associated with a higher chance of survival.