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dc.contributor.authorArévalo Suárez, Fernando*
dc.contributor.authorPortugal, Sabino*
dc.contributor.authorBarreda, Carlos*
dc.contributor.authorMontes, Pedro*
dc.contributor.authorPerez-Narrea, María Teresa*
dc.contributor.authorRodríguez, Omar*
dc.contributor.authorVergara, Greys*
dc.contributor.authorMonge, Eduardo*
dc.date.accessioned2016-07-20T21:11:08Z
dc.date.available2016-07-20T21:11:08Z
dc.date.issued2016-06
dc.identifier.citationArévalo Suárez F, Portugal S, Barreda C, Montes P, Perez-Narrea MT, Rodríguez O, et al. Enfermedad celíaca vs. atrofia villositaria serológicamente negativa: similitudes y diferencias histológicas y en el perfil inmunohistoquímico de linfocitos CD3, CD4, CD8 y CD56. Rev Gastroenterol Peru. 2016;36(2):123-8es_PE
dc.identifier.issn1022-5129
dc.identifier.urihttp://hdl.handle.net/10757/617280es_PE
dc.description.abstractThere is a group of enteropathies recently known as seronegative villous atrophy (SNVA), which can simulate celiac disease. Objective: The aim of this study was to describe histological and immunohistochemical differences between a group of Celiac disease and SNVA patients. Material and methods: Microscopy reexamination and Immunohistochemistry study were performed for a group of 15 celiac patients and 19 SNVA patients. Histological features as severe atrophy, crypt hyperplasia, plasma cells number, eosinophils number, neutrophils presence were studied; CD4, CD8, CD3, and CD56 markers were studied through immunohistochemistry. Results: There was a significant difference between the frequency of observation of crypt hyperplasia (p=0.0348) and plasma cells (p=0.0348) in celiac disease patients than SNVA patients. In celiac disease was bigger. The number and distribution of CD 8, CD4 and CD56 lymphocytes was similar in both groups. The percentage of CD3 positive intraepithelial lymphocytes (p=0.0144) was higher in SNVA. Conclusion: Histological and immunohistochemical evaluation shows more similarities than differences. The differences found in this study suggest more humoral immune response in celiac disease than in SNVA.
dc.formatapplication/pdfes_PE
dc.language.isospaes_PE
dc.publisherSociedad de Gastroenterología del Perú (SGP)es_PE
dc.relation.urlhttp://www.scielo.org.pe/scielo.php?script=sci_arttext&pid=S1022-51292016000200004&lng=es&nrm=iso&tlng=eses_PE
dc.rightsinfo:eu-repo/semantics/openAccesses_PE
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.sourceUniversidad Peruana de Ciencias Aplicadas (UPC)es_PE
dc.sourceRepositorio Académico - UPCes_PE
dc.subjectnfermedad celíacaes_PE
dc.subjectAntígenos CD8es_PE
dc.subjectAntígenos CD4es_PE
dc.subjectAntígenos CD56es_PE
dc.subjectHiperplasiaes_PE
dc.subjectCeliac diseasees_PE
dc.subjectAntigenses_PE
dc.subjectCD8es_PE
dc.subjectCD56es_PE
dc.subjectHyperplasiaes_PE
dc.titleEnfermedad celíaca vs. atrofia villositaria serológicamente negativa: similitudes y diferencias histológicas y en el perfil inmunohistoquímico de linfocitos CD3, CD4, CD8 y CD56es_PE
dc.title.alternativeCeliac disease and negative serology villous atrophy: histological comparison and immunohistochemical study of CD3, CD4, CD8 and CD56 lymphocyteses_PE
dc.typeinfo:eu-repo/semantics/articlees_PE
dc.identifier.journalRevista de Gastroenterología del Perú (Rev Gastroenterol Peru)es_PE
dc.description.peer-reviewRevisión por pareses_PE
dc.contributor.emailhistodiagnostico1303@hotmail.comes_PE
refterms.dateFOA2018-06-17T03:48:20Z
html.description.abstractExiste un grupo de enteropatía conocidas como AVSN que pueden simular enfermedad celíaca. Objetivo: El objetivo de este estudio es describir los hallazgos histológicos y de inmunohistoquímica en pacientes con enfermedad celíaca y AVSN. Material y métodos: 15 biopsias de pacientes con enfermedad celíaca y 19 biopsias con AVSN fueron reexaminados. Se estudió características histológicas tales como atrofia severa, hiperplasia de criptas, número de células plasmáticas, número de eosinófilos y presencia de neutrófilos. Asimismo, a través de inmunohistoquímica se estudió la presencia de linfocitos CD4, CD8, CD3, CD56. Resultados: Se encontró diferencia significativa en la mayor presencia de hiperplasia de criptas (p=0,0348) y mayor número de células plasmáticas (p=0,0348) en las biopsias de enfermedad celíaca que en las catalogadas como AVSN. El número de linfocitos CD8, CD4, CD56 y su distribución fue similar en ambos grupos. El porcentaje de linfocitos intraepiteliales CD3 positivos (p=0,0144) fue mayor en pacientes con AVSN. Conclusión: Los hallazgos histológicos e inmunohistoquímicos muestran más similitudes que diferencias. La diferencia hallada en nuestro estudio sugiere mayor respuesta inmune humoral en pacientes con enfermedad celiaca que en AVSN.
html.description.abstractThere is a group of enteropathies recently known as seronegative villous atrophy (SNVA), which can simulate celiac disease. Objective: The aim of this study was to describe histological and immunohistochemical differences between a group of Celiac disease and SNVA patients. Material and methods: Microscopy reexamination and Immunohistochemistry study were performed for a group of 15 celiac patients and 19 SNVA patients. Histological features as severe atrophy, crypt hyperplasia, plasma cells number, eosinophils number, neutrophils presence were studied; CD4, CD8, CD3, and CD56 markers were studied through immunohistochemistry. Results: There was a significant difference between the frequency of observation of crypt hyperplasia (p=0.0348) and plasma cells (p=0.0348) in celiac disease patients than SNVA patients. In celiac disease was bigger. The number and distribution of CD 8, CD4 and CD56 lymphocytes was similar in both groups. The percentage of CD3 positive intraepithelial lymphocytes (p=0.0144) was higher in SNVA. Conclusion: Histological and immunohistochemical evaluation shows more similarities than differences. The differences found in this study suggest more humoral immune response in celiac disease than in SNVA.


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