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Serum brain-derived neurotrophic factor (BDNF) concentrations in pregnant women with post-traumatic stress disorder and comorbid depression

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Authors
Yang, Na
Gelaye, Bizu
Zhong, Qiuyue
Rondon, Marta B.
Sanchez, Sixto E.
Williams, Michelle A.
Issue Date
2016-05-19
Keywords
Biomarker
BDNF
Antepartum PTSD
Antepartum depression
Peru
xmlui.metadata.dc.contributor.email
bgelaye@hsph.harvard.edu

Metadata
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Citation
Serum brain-derived neurotrophic factor (BDNF) concentrations in pregnant women with post-traumatic stress disorder and comorbid depression 2016 Archives of Women's Mental Health
Publisher
Springer International Publishing
Journal
Archives of Women's Mental Health (Arch Womens Ment Health)
URI
http://hdl.handle.net/10757/610659
DOI
10.1007/s00737-016-0638-0
Additional Links
http://link.springer.com/10.1007/s00737-016-0638-0
Abstract
There is accumulating evidence for the role of brain-derived neurotrophic factor (BDNF) in the pathophysiology of depression. However, the role of BDNF in the pathophysiology of post-traumatic stress disorder (PTSD) remains controversial, and no study has assessed BDNF concentrations among pregnant women with PTSD. We examined early-pregnancy BDNF concentrations among women with PTSD with and without depression. A total of 2928 women attending prenatal care clinics in Lima, Peru, were recruited. Antepartum PTSD and depression were evaluated using PTSD Checklist—Civilian Version (PCL-C) and Patient Health Questionnaire-9 (PHQ-9) scales, respectively. BDNF concentrations were measured in a subset of the cohort (N = 944) using a competitive enzyme-linked immunosorbent assay (ELISA). Logistic regression procedures were used to estimate odds ratios (OR) and 95 % confidence intervals (95 % CI). Antepartum PTSD (37.4 %) and depression (27.6 %) were prevalent in this cohort of low-income pregnant Peruvian women. Approximately 19.9 % of participants had comorbid PTSD-depression. Median serum BDNF concentrations were lower among women with comorbid PTSD-depression as compared with women without either condition (median [interquartile range], 20.44 [16.97–24.30] vs. 21.35 [17.33–26.01] ng/ml; P = 0.06). Compared to the referent group (those without PTSD and depression), women with comorbid PTSD-depression were 1.52-fold more likely to have low (<25.38 ng/ml) BDNF concentrations (OR = 1.52; 95 % CI 1.00–2.31). We observed no evidence of reduced BDNF concentrations among women with isolated PTSD. BDNF concentrations in early pregnancy were only minimally and non-significantly reduced among women with antepartum PTSD. Reductions in BDNF concentrations were more pronounced among women with comorbid PTSD-depression.
Type
info:eu-repo/semantics/article
Rights
info:eu-repo/semantics/embargoedAccess
Language
eng
Description
El texto completo de este trabajo no está disponible en el Repositorio Académico UPC por restricciones de la casa editorial donde ha sido publicado.
ISSN
1434-1816
1435-1102
ae974a485f413a2113503eed53cd6c53
10.1007/s00737-016-0638-0
Scopus Count
Collections
Medicina

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