Prevalence of BRCA1 and BRCA2 mutations in unselected breast cancer patients from Peru.
Average rating
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Star rating
Your vote was cast
Thank you for your feedback
Thank you for your feedback
Authors
Abugattas, JLlacuachaqui, M
Allende, Y Sullcahuaman
Velásquez, A Arias
Velarde, R
Cotrina, J
Garcés, M
León, M
Calderón, G
de la Cruz, M
Mora, P
Royer, R
Herzog, J
Weitzel, J N
Narod, S A
Issue Date
2015-10xmlui.metadata.dc.contributor.email
steven.narod@wchospital.ca
Metadata
Show full item recordCitation
Prevalence of BRCA1 and BRCA2 mutations in unselected breast cancer patients from Peru. 2015, 88 (4):371-5 Clin. Genet.Publisher
John Wiley & Sons, Inc.Journal
Clinical genetics (Clin Genet.)DOI
10.1111/cge.12505PubMed ID
25256238Additional Links
http://www.ncbi.nlm.nih.gov/pubmed/25256238Abstract
The prevalence of BRCA1 and BRCA2 mutations among breast cancer patients in Peru has not yet been explored. We enrolled 266 women with breast cancer from a National cancer hospital in Lima, Peru, unselected for age or family history. DNA was screened with a panel of 114 recurrent Hispanic BRCA mutations (HISPANEL). Among the 266 cases, 13 deleterious mutations were identified (11 in BRCA1 and 2 in BRCA2), representing 5% of the total. The average age of breast cancer in the mutation-positive cases was 44 years. BRCA1 185delAG represented 7 of 11 mutations in BRCA1. Other mutations detected in BRCA1 included: two 2080delA, one 943ins10, and one 3878delTA. The BRCA2 3036del4 mutation was seen in two patients. Given the relatively low cost of the HISPANEL test, one should consider offering this test to all Peruvian women with breast or ovarian cancer.Type
info:eu-repo/semantics/articleRights
info:eu-repo/semantics/embargoedAccessLanguage
engDescription
El texto completo de este trabajo no está disponible en el Repositorio Académico UPC por restricciones de la casa editorial donde ha sido publicado.ISSN
1399-0004ae974a485f413a2113503eed53cd6c53
10.1111/cge.12505
Scopus Count
Collections
Related articles
- Significant clinical impact of recurrent BRCA1 and BRCA2 mutations in Mexico.
- Authors: Villarreal-Garza C, Alvarez-Gómez RM, Pérez-Plasencia C, Herrera LA, Herzog J, Castillo D, Mohar A, Castro C, Gallardo LN, Gallardo D, Santibáñez M, Blazer KR, Weitzel JN
- Issue date: 2015 Feb 1
- BRCA1 and BRCA2 mutations in ethnic Lebanese Arab women with high hereditary risk breast cancer.
- Authors: El Saghir NS, Zgheib NK, Assi HA, Khoury KE, Bidet Y, Jaber SM, Charara RN, Farhat RA, Kreidieh FY, Decousus S, Romero P, Nemer GM, Salem Z, Shamseddine A, Tfayli A, Abbas J, Jamali F, Seoud M, Armstrong DK, Bignon YJ, Uhrhammer N
- Issue date: 2015 Apr
- Prevalence of BRCA1 and BRCA2 mutations in Pakistani breast and ovarian cancer patients.
- Authors: Rashid MU, Zaidi A, Torres D, Sultan F, Benner A, Naqvi B, Shakoori AR, Seidel-Renkert A, Farooq H, Narod S, Amin A, Hamann U
- Issue date: 2006 Dec 15
- Spectrum and characterisation of BRCA1 and BRCA2 deleterious mutations in high-risk Czech patients with breast and/or ovarian cancer.
- Authors: Machackova E, Foretova L, Lukesova M, Vasickova P, Navratilova M, Coene I, Pavlu H, Kosinova V, Kuklova J, Claes K
- Issue date: 2008 May 20
- The prevalence of BRCA1 and BRCA2 mutations among young Mexican women with triple-negative breast cancer.
- Authors: Villarreal-Garza C, Weitzel JN, Llacuachaqui M, Sifuentes E, Magallanes-Hoyos MC, Gallardo L, Alvarez-Gómez RM, Herzog J, Castillo D, Royer R, Akbari M, Lara-Medina F, Herrera LA, Mohar A, Narod SA
- Issue date: 2015 Apr