Risk factors for recurrent Clostridium difficile infection: a systematic review and meta-analysis.
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Your vote was cast
Thank you for your feedback
Thank you for your feedback
Rolston, David D K
Hernandez, Adrian V.
Donskey, Curtis J
Fraser, Thomas G
MetadataShow full item record
CitationRisk factors for recurrent Clostridium difficile infection: a systematic review and meta-analysis. 2015, 36 (4):452-60 Infect Control Hosp Epidemiol
PublisherCambridge University Press
JournalInfection control and hospital epidemiology (Infect Control Hosp Epidemiol)
AbstractOBJECTIVE: An estimated 20-30% of patients with primary Clostridium difficile infection (CDI) develop recurrent CDI (rCDI) within 2 weeks of completion of therapy. While the actual mechanism of recurrence remains unknown, a variety of risk factors have been suggested and studied. The aim of this systematic review and meta-analysis was to evaluate current evidence on the risk factors for rCDI. DESIGN: We searched MEDLINE and 5 other databases for subject headings and text related to rCDI. All studies investigating risk factors of rCDI in a multivariate model were eligible. Information on study design, patient population, and assessed risk factors were collected. Data were combined using a random-effects model and pooled relative risk ratios (RRs) were calculated. RESULTS: A total of 33 studies (n=18,530) met the inclusion criteria. The most frequent independent risk factors associated with rCDI were age≥65 years (risk ratio [RR], 1.63; 95% confidence interval [CI], 1.24-2.14; P=.0005), additional antibiotics during follow-up (RR, 1.76; 95% CI, 1.52-2.05; P<.00001), use of proton-pump inhibitors (PPIs) (RR, 1.58; 95% CI, 1.13-2.21; P=.008), and renal insufficiency (RR, 1.59; 95% CI, 1.14-2.23; P=.007). The risk was also greater in patients previously on fluoroquinolones (RR, 1.42; 95% CI, 1.28-1.57; P<.00001). CONCLUSIONS: Multiple risk factors are associated with the development of rCDI. Identification of modifiable risk factors and judicious use of antibiotics and PPI can play an important role in the prevention of rCDI.
DescriptionEl texto completo de este trabajo no está disponible en el Repositorio Académico UPC por restricciones de la casa editorial donde ha sido publicado.
- Risk factors for recurrent Clostridium difficile infection in hematopoietic stem cell transplant recipients.
- Authors: Huang AM, Marini BL, Frame D, Aronoff DM, Nagel JL
- Issue date: 2014 Oct
- Risk of Clostridium difficile infection with acid suppressing drugs and antibiotics: meta-analysis.
- Authors: Kwok CS, Arthur AK, Anibueze CI, Singh S, Cavallazzi R, Loke YK
- Issue date: 2012 Jul
- Recurrence of Clostridium difficile Infection in Patients with Inflammatory Bowel Disease: The RECIDIVISM Study.
- Authors: Razik R, Rumman A, Bahreini Z, McGeer A, Nguyen GC
- Issue date: 2016 Aug
- Risk factors for recurrent Clostridium difficile infection (CDI) hospitalization among hospitalized patients with an initial CDI episode: a retrospective cohort study.
- Authors: Zilberberg MD, Reske K, Olsen M, Yan Y, Dubberke ER
- Issue date: 2014 Jun 4
- Association between proton pump inhibitor therapy and clostridium difficile infection: a contemporary systematic review and meta-analysis.
- Authors: Tleyjeh IM, Bin Abdulhak AA, Riaz M, Alasmari FA, Garbati MA, AlGhamdi M, Khan AR, Al Tannir M, Erwin PJ, Ibrahim T, Allehibi A, Baddour LM, Sutton AJ
- Issue date: 2012