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dc.contributor.authorPhan, Tung Gia*
dc.contributor.authorda Costa, Antonio Charlys*
dc.contributor.authorDel Valle Mendoza, Juana*
dc.contributor.authorBucardo Rivera, Filemon*
dc.contributor.authorNordgren, Johan*
dc.contributor.authorO'Ryan, Miguel*
dc.contributor.authorDeng, Xutao*
dc.contributor.authorDelwart, Eric*
dc.date.accessioned2016-04-05T17:54:13Zes_PE
dc.date.available2016-04-05T17:54:13Zes_PE
dc.date.issued2016-04es_PE
dc.identifier.citationThe fecal virome of South and Central American children with diarrhea includes small circular DNA viral genomes of unknown origin. 2016, 161 (4):959-66 Arch. Virol.es_PE
dc.identifier.issn1432-8798es_PE
dc.identifier.pmid26780893es_PE
dc.identifier.doi10.1007/s00705-016-2756-4es_PE
dc.identifier.urihttp://hdl.handle.net/10757/604552es_PE
dc.description.abstractViral metagenomics of feces collected from 58 Peruvian children with unexplained diarrhea revealed several small circular ssDNA genomes. Two genomes related to sequences previously reported in feces from chimpanzees and other mammals and recently named smacoviruses were characterized and then detected by PCR in 1.7 % (1/58) and 19 % (11/58) of diarrheal samples, respectively. Another three genomes from a distinct small circular ssDNA viral group provisionally called pecoviruses encoded Cap and Rep proteins with <35 % identity to those in related genomes reported in human, seal, porcine and dromedary feces. Pecovirus DNA was detected in 15.5 % (9/58), 5.9 % (3/51) and 3 % (3/100) of fecal samples from unexplained diarrhea in Peru, Nicaragua and Chile, respectively. Feces containing these ssDNA genomes also contained known human enteric viral pathogens. The cellular origins of these circular ssDNA viruses, whether human cells, ingested plants, animals or fungal foods, or residents of the gut microbiome, are currently unknown.
dc.description.sponsorshipThis study was funded by NHLBI Grant R01 HL105770 to E.L.D and by Sao Paulo Research Foundation (FAPESP) Grant numbers 2014/05211-2 and 2012/03417-7 to A.C.C.es_PE
dc.formatapplication/pdfes_PE
dc.language.isoenges_PE
dc.publisherSpringer International Publishinges_PE
dc.relation.urlhttp://www.ncbi.nlm.nih.gov/pubmed/26780893es_PE
dc.rightsinfo:eu-repo/semantics/openAccesses_PE
dc.sourceUniversidad Peruana de Ciencias Aplicadas (UPC)es_PE
dc.sourceRepositorio Académico - UPCes_PE
dc.subjectDiarrheaes_PE
dc.subjectDNA viral genomeses_PE
dc.subjectCentral Americanes_PE
dc.subjectSouth Americanes_PE
dc.titleThe fecal virome of South and Central American children with diarrhea includes small circular DNA viral genomes of unknown origin.es_PE
dc.typeinfo:eu-repo/semantics/articlees_PE
dc.identifier.journalArchives of virology (Arch Virol.)es_PE
dc.description.peer-reviewRevisión por pareses_PE
dc.contributor.emaildelwarte@medicine.ucsf.edues_PE
refterms.dateFOA2018-06-15T19:16:13Z
html.description.abstractViral metagenomics of feces collected from 58 Peruvian children with unexplained diarrhea revealed several small circular ssDNA genomes. Two genomes related to sequences previously reported in feces from chimpanzees and other mammals and recently named smacoviruses were characterized and then detected by PCR in 1.7 % (1/58) and 19 % (11/58) of diarrheal samples, respectively. Another three genomes from a distinct small circular ssDNA viral group provisionally called pecoviruses encoded Cap and Rep proteins with <35 % identity to those in related genomes reported in human, seal, porcine and dromedary feces. Pecovirus DNA was detected in 15.5 % (9/58), 5.9 % (3/51) and 3 % (3/100) of fecal samples from unexplained diarrhea in Peru, Nicaragua and Chile, respectively. Feces containing these ssDNA genomes also contained known human enteric viral pathogens. The cellular origins of these circular ssDNA viruses, whether human cells, ingested plants, animals or fungal foods, or residents of the gut microbiome, are currently unknown.


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