The fecal virome of South and Central American children with diarrhea includes small circular DNA viral genomes of unknown origin.
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Your vote was cast
Thank you for your feedback
Thank you for your feedback
AuthorsPhan, Tung Gia
da Costa, Antonio Charlys
Del Valle Mendoza, Juana
Bucardo Rivera, Filemon
MetadataShow full item record
CitationThe fecal virome of South and Central American children with diarrhea includes small circular DNA viral genomes of unknown origin. 2016, 161 (4):959-66 Arch. Virol.
PublisherSpringer International Publishing
JournalArchives of virology (Arch Virol.)
AbstractViral metagenomics of feces collected from 58 Peruvian children with unexplained diarrhea revealed several small circular ssDNA genomes. Two genomes related to sequences previously reported in feces from chimpanzees and other mammals and recently named smacoviruses were characterized and then detected by PCR in 1.7 % (1/58) and 19 % (11/58) of diarrheal samples, respectively. Another three genomes from a distinct small circular ssDNA viral group provisionally called pecoviruses encoded Cap and Rep proteins with <35 % identity to those in related genomes reported in human, seal, porcine and dromedary feces. Pecovirus DNA was detected in 15.5 % (9/58), 5.9 % (3/51) and 3 % (3/100) of fecal samples from unexplained diarrhea in Peru, Nicaragua and Chile, respectively. Feces containing these ssDNA genomes also contained known human enteric viral pathogens. The cellular origins of these circular ssDNA viruses, whether human cells, ingested plants, animals or fungal foods, or residents of the gut microbiome, are currently unknown.
SponsorsThis study was funded by NHLBI Grant R01 HL105770 to E.L.D and by Sao Paulo Research Foundation (FAPESP) Grant numbers 2014/05211-2 and 2012/03417-7 to A.C.C.
- Gut Virome Analysis of Cameroonians Reveals High Diversity of Enteric Viruses, Including Potential Interspecies Transmitted Viruses.
- Authors: Yinda CK, Vanhulle E, Conceição-Neto N, Beller L, Deboutte W, Shi C, Ghogomu SM, Maes P, Van Ranst M, Matthijnssens J
- Issue date: 2019 Jan 23
- Small circular single stranded DNA viral genomes in unexplained cases of human encephalitis, diarrhea, and in untreated sewage.
- Authors: Phan TG, Mori D, Deng X, Rajindrajith S, Ranawaka U, Fan Ng TF, Bucardo-Rivera F, Orlandi P, Ahmed K, Delwart E
- Issue date: 2015 Aug
- Rapidly expanding genetic diversity and host range of the Circoviridae viral family and other Rep encoding small circular ssDNA genomes.
- Authors: Delwart E, Li L
- Issue date: 2012 Mar
- Circular replication-associated protein encoding DNA viruses identified in the faecal matter of various animals in New Zealand.
- Authors: Steel O, Kraberger S, Sikorski A, Young LM, Catchpole RJ, Stevens AJ, Ladley JJ, Coray DS, Stainton D, Dayaram A, Julian L, van Bysterveldt K, Varsani A
- Issue date: 2016 Sep
- Two novel circo-like viruses detected in human feces: complete genome sequencing and electron microscopy analysis.
- Authors: Castrignano SB, Nagasse-Sugahara TK, Kisielius JJ, Ueda-Ito M, Brandão PE, Curti SP
- Issue date: 2013 Dec 26