The fecal virome of South and Central American children with diarrhea includes small circular DNA viral genomes of unknown origin.
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AuthorsPhan, Tung Gia
da Costa, Antonio Charlys
Del Valle Mendoza, Juana
Bucardo Rivera, Filemon
MetadataShow full item record
CitationThe fecal virome of South and Central American children with diarrhea includes small circular DNA viral genomes of unknown origin. 2016, 161 (4):959-66 Arch. Virol.
PublisherSpringer International Publishing
JournalArchives of virology (Arch Virol.)
AbstractViral metagenomics of feces collected from 58 Peruvian children with unexplained diarrhea revealed several small circular ssDNA genomes. Two genomes related to sequences previously reported in feces from chimpanzees and other mammals and recently named smacoviruses were characterized and then detected by PCR in 1.7 % (1/58) and 19 % (11/58) of diarrheal samples, respectively. Another three genomes from a distinct small circular ssDNA viral group provisionally called pecoviruses encoded Cap and Rep proteins with <35 % identity to those in related genomes reported in human, seal, porcine and dromedary feces. Pecovirus DNA was detected in 15.5 % (9/58), 5.9 % (3/51) and 3 % (3/100) of fecal samples from unexplained diarrhea in Peru, Nicaragua and Chile, respectively. Feces containing these ssDNA genomes also contained known human enteric viral pathogens. The cellular origins of these circular ssDNA viruses, whether human cells, ingested plants, animals or fungal foods, or residents of the gut microbiome, are currently unknown.
SponsorsThis study was funded by NHLBI Grant R01 HL105770 to E.L.D and by Sao Paulo Research Foundation (FAPESP) Grant numbers 2014/05211-2 and 2012/03417-7 to A.C.C.
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