Detection of Bordetella pertussis using a PCR test in infants younger 3 than one year old hospitalized with whooping cough in five 4 Peruvian hospitals

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Authors
Castillo, María Esther
Bada, Carlos
Del Aguila, Olguita
Petrozzi Helasvuo, Verónica
Casabona Ore, Verónica
Reyes, Isabel
Del Valle Mendoza, Juana Mercedes
Issue Date
2015-11-24
Keywords
Whooping cough
PCR
Peru
Bordetella pertussis

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Citation
Castillo ME, et al. Detection of Bordetella pertussis using a PCR test in infants younger than one year old hospitalized with whooping cough in five Peruvian hospitals. Int J Infect Dis (2015), http://dx.doi.org/10.1016/j.ijid.2015.10.020
Publisher
International Society for Infectious Diseases (Int J Infect Dis)
Journal
International Journal of Infectious Diseases
URI
http://hdl.handle.net/10757/582607
DOI
10.1016/j.ijid.2015.10.020
Additional Links
http://www.sciencedirect.com/science/article/pii/S1201971215002544
Type
info:eu-repo/semantics/article
Rights
info:eu-repo/semantics/openAccess
Language
eng
Description
Objectives To report the incidence, epidemiology, and clinical features of Bordetella pertussis in Peruvian infants under 1 year old. Patients and methods A prospective cross-sectional study was conducted in five hospitals in Peru from January 2010 to July 2012. A total of 392 infants under 1 year old were admitted with a clinical diagnosis of whooping cough and tested for B. pertussis by PCR. Results The pertussis toxin and IS481 genes were detected in 39.54% (155/392) of the cases. Infants aged less than 3 months were the most affected, with a prevalence of 73.55% (114/155). The most common household contact was the mother, identified in 20% (31/155) of cases. Paroxysm of coughing (89.03%, 138/155), cyanosis (68.39%, 106/155), respiratory distress (67.09%, 104/155), and breastfeeding difficulties (39.35%, 61/155) were the most frequent symptoms reported. Conclusion An increase in pertussis cases has been reported in recent years in Peru, despite national immunization efforts. Surveillance with PCR for B. pertussis is essential, especially in infants less than 1 year old, in whom a higher rate of disease-related complications and higher mortality have been reported.
ISSN
1201-9712
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