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Impaired Functional Capacity Predicts Mortality in Patients with Obstructive Sleep Apnea

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Authors
Nisar, Shiraz A.
Muppidi, Raghunandan
Duggal, Sumit
Hernández, Adrian V.
Kalahasti, Vidyasagar
Jaber, Wael
Minai, Omar A.
Issue Date
2014-12-16
Keywords
Sleep apnea
Coronary artery disease
Mortality
Polysomnography
Impaired functional capacity

Metadata
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Publisher
The American Thoracic Society
Journal
Annals of the American Thoracic Society
URI
http://hdl.handle.net/10757/337271
DOI
10.1513/AnnalsATS.201309-315OC
Additional Links
http://www.atsjournals.org/doi/abs/10.1513/AnnalsATS.201309-315OC#.VJCdb9IrfTo
Abstract
Background: Obstructive sleep apnea (OSA) is associated with increased mortality, for which impaired functional capacity (IFC) has been established as a surrogate. We sought to assess whether IFC is associated with increased mortality in patients with OSA and whether IFC is predictive of increased mortality after accounting for coronary artery disease. Methods: Patients with OSA who underwent both polysomnography testing and exercise stress echocardiogram were selected. Records were reviewed retrospectively for demographics, comorbidities, stress echocardiographic parameters, and polysomnography data. Univariable and multivariable logistic regression analysis was used to evaluate the association between IFC and overall mortality. We then evaluated the variables associated with IFC in the overall population and in the subgroup with normal Duke treadmill score (DTS). Results: In our cohort, 404 (26%) patients had IFC. The best predictors of IFC were female sex, history of smoking, ejection fraction less than 55, increased body mass index, presence of comorbidities, abnormal exercise echocardiogram, abnormal heart rate recovery, and abnormal DTS. Compared with those without IFC, patients with IFC were 5.1 times more likely to die (odds ratio [OR], 5.1; 95% confidence interval [CI], 2.5–10.5; P , 0.0001) by univariate analysis and 2.7 times more likely to die (OR, 2.7; 95% CI, 1.2–6.1; P = 0.02) by multivariate analysis, when accounting for heart rate recovery, DTS, and sleep apnea severity. Among those without coronary artery disease, patients with IFC were at significantly increased risk of mortality (OR, 4.3; 95% CI, 1.35–13.79; P = 0.0088) compared with those with preserved functional capacity. Conclusions: In our OSA population, IFC was a strong predictor of increased mortality. Among those with normal DTS, IFC identified a cohort at increased risk of mortality.
Type
info:eu-repo/semantics/article
Rights
info:eu-repo/semantics/openAccess
Language
eng
Description
oam1998@outlook.com
ae974a485f413a2113503eed53cd6c53
10.1513/AnnalsATS.201309-315OC
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