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Antiviral activity of maca (Lepidium meyenii) against human influenza virus
dc.contributor.author | Del Valle Mendoza, Juana | * |
dc.contributor.author | Pumarola, Tomàs | * |
dc.contributor.author | Alzamora Gonzales, Libertad | * |
dc.contributor.author | Del Valle, Luis J. | * |
dc.date.accessioned | 2014-11-21T00:58:58Z | es_PE |
dc.date.available | 2014-11-21T00:58:58Z | es_PE |
dc.date.issued | 2014-11-20 | es_PE |
dc.identifier.citation | Del Valle Mendoza J, Pumarola T, Gonzales LA, del Valle LJ. Antiviral activity of maca (Lepidium meyenii) against human influenza virus. Asian Pacific Journal of Tropical Medicine. septiembre de 2014;7, Supplement 1:S415-20. | es_PE |
dc.identifier.issn | 1995-7645 | es_PE |
dc.identifier.doi | 10.1016/S1995-7645(14)60268-6 | es_PE |
dc.identifier.uri | http://hdl.handle.net/10757/335865 | es_PE |
dc.description.abstract | Objective: To investigate antiviral activity of maca to reduce viral load in kidney (MDCK) cells infected with influenza type A and B viruses (Flu-A and MFalud-inB-, Dreasrpbeyc ctiavneilny)e. Methods: Maca were extracted with methanol (1:2, v/v). The cell viability and toxicity of the eaxgtariancstts Fwluer-eA e avnaldu aFtleud- oBn v MirDusCeKs cwealsls a usssianyge dm uetshinogd aM TteTs ta sfosar yd. eAtenrtmiviinrainl ga ctthiev itiyn hoifb citoimonp oouf nthdes cytopathic effect on cell culture and multiplex RT-PCR. Results: The methanol extract of maca showed low cytotoxicity and inhibited influenza-induced cytopathic effect significantly, while viral load was reduced via inhibition of viral growth in MDCK infected cells. Maca contains potent inhibitors of Flu-A and Flu-B with a selectivity index [cytotoxic concentration 50%/IC50] of 157.4 and 110.5, respectively. Conclusions: In vitro assays demonstrated that maca has antiviral activity not only against Flu-A (like most antiviral agents) but also Flu-B viruses, providing remarkable therapeutic benefits. | |
dc.description.sponsorship | Financial support of this study was provided by AECID grants (PCI: C/033641/10) and AGAUR (MAT2009-11503, MAT2012-36205, 2009SGR-1208). JDVM support was provided by 1st Concurso Incentivo a la Investigación de la Universidad Peruana de Ciencias Aplicadas, Lima, Peru. | es_PE |
dc.format | application/pdf | es_PE |
dc.language.iso | eng | es_PE |
dc.publisher | Elsevier B.V. | es_PE |
dc.relation.url | http://www.sciencedirect.com/science/article/pii/S1995764514602686 | es_PE |
dc.rights | info:eu-repo/semantics/openAccess | es_PE |
dc.source | Universidad Peruana de Ciencias Aplicadas (UPC) | es_PE |
dc.source | Repositorio Académico - UPC | es_PE |
dc.subject | Influenza virus flu | es_PE |
dc.subject | Antiviral activity | es_PE |
dc.subject | Lepidium meyenii | es_PE |
dc.subject | Maca | es_PE |
dc.title | Antiviral activity of maca (Lepidium meyenii) against human influenza virus | es_PE |
dc.type | info:eu-repo/semantics/article | es_PE |
dc.identifier.journal | Asian Pacific Journal of Tropical Medicine | es_PE |
dc.description.peer-review | Revisión por pares | es_PE |
dc.contributor.email | [email protected] | es_PE |
refterms.dateFOA | 2018-06-19T05:04:49Z | |
html.description.abstract | Objective: To investigate antiviral activity of maca to reduce viral load in kidney (MDCK) cells infected with influenza type A and B viruses (Flu-A and MFalud-inB-, Dreasrpbeyc ctiavneilny)e. Methods: Maca were extracted with methanol (1:2, v/v). The cell viability and toxicity of the eaxgtariancstts Fwluer-eA e avnaldu aFtleud- oBn v MirDusCeKs cwealsls a usssianyge dm uetshinogd aM TteTs ta sfosar yd. eAtenrtmiviinrainl ga ctthiev itiyn hoifb citoimonp oouf nthdes cytopathic effect on cell culture and multiplex RT-PCR. Results: The methanol extract of maca showed low cytotoxicity and inhibited influenza-induced cytopathic effect significantly, while viral load was reduced via inhibition of viral growth in MDCK infected cells. Maca contains potent inhibitors of Flu-A and Flu-B with a selectivity index [cytotoxic concentration 50%/IC50] of 157.4 and 110.5, respectively. Conclusions: In vitro assays demonstrated that maca has antiviral activity not only against Flu-A (like most antiviral agents) but also Flu-B viruses, providing remarkable therapeutic benefits. |
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