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dc.contributor.authorDel Valle Mendoza, Juana*
dc.contributor.authorPumarola, Tomàs*
dc.contributor.authorAlzamora Gonzales, Libertad*
dc.contributor.authorDel Valle, Luis J.*
dc.date.accessioned2014-11-21T00:58:58Zes_PE
dc.date.available2014-11-21T00:58:58Zes_PE
dc.date.issued2014-11-20es_PE
dc.identifier.citationDel Valle Mendoza J, Pumarola T, Gonzales LA, del Valle LJ. Antiviral activity of maca (Lepidium meyenii) against human influenza virus. Asian Pacific Journal of Tropical Medicine. septiembre de 2014;7, Supplement 1:S415-20.es_PE
dc.identifier.issn1995-7645es_PE
dc.identifier.doi10.1016/S1995-7645(14)60268-6es_PE
dc.identifier.urihttp://hdl.handle.net/10757/335865es_PE
dc.description.abstractObjective: To investigate antiviral activity of maca to reduce viral load in kidney (MDCK) cells infected with influenza type A and B viruses (Flu-A and MFalud-inB-, Dreasrpbeyc ctiavneilny)e. Methods: Maca were extracted with methanol (1:2, v/v). The cell viability and toxicity of the eaxgtariancstts Fwluer-eA e avnaldu aFtleud- oBn v MirDusCeKs cwealsls a usssianyge dm uetshinogd aM TteTs ta sfosar yd. eAtenrtmiviinrainl ga ctthiev itiyn hoifb citoimonp oouf nthdes cytopathic effect on cell culture and multiplex RT-PCR. Results: The methanol extract of maca showed low cytotoxicity and inhibited influenza-induced cytopathic effect significantly, while viral load was reduced via inhibition of viral growth in MDCK infected cells. Maca contains potent inhibitors of Flu-A and Flu-B with a selectivity index [cytotoxic concentration 50%/IC50] of 157.4 and 110.5, respectively. Conclusions: In vitro assays demonstrated that maca has antiviral activity not only against Flu-A (like most antiviral agents) but also Flu-B viruses, providing remarkable therapeutic benefits.
dc.description.sponsorshipFinancial support of this study was provided by AECID grants (PCI: C/033641/10) and AGAUR (MAT2009-11503, MAT2012-36205, 2009SGR-1208). JDVM support was provided by 1st Concurso Incentivo a la Investigación de la Universidad Peruana de Ciencias Aplicadas, Lima, Peru.es_PE
dc.formatapplication/pdfes_PE
dc.language.isoenges_PE
dc.publisherElsevier B.V.es_PE
dc.relation.urlhttp://www.sciencedirect.com/science/article/pii/S1995764514602686es_PE
dc.rightsinfo:eu-repo/semantics/openAccesses_PE
dc.sourceUniversidad Peruana de Ciencias Aplicadas (UPC)es_PE
dc.sourceRepositorio Académico - UPCes_PE
dc.subjectInfluenza virus flues_PE
dc.subjectAntiviral activityes_PE
dc.subjectLepidium meyeniies_PE
dc.subjectMacaes_PE
dc.titleAntiviral activity of maca (Lepidium meyenii) against human influenza viruses_PE
dc.typeinfo:eu-repo/semantics/articlees_PE
dc.identifier.journalAsian Pacific Journal of Tropical Medicinees_PE
dc.description.peer-reviewRevisión por pareses_PE
dc.contributor.emailjdevall@upc.edu.pees_PE
refterms.dateFOA2018-06-19T05:04:49Z
html.description.abstractObjective: To investigate antiviral activity of maca to reduce viral load in kidney (MDCK) cells infected with influenza type A and B viruses (Flu-A and MFalud-inB-, Dreasrpbeyc ctiavneilny)e. Methods: Maca were extracted with methanol (1:2, v/v). The cell viability and toxicity of the eaxgtariancstts Fwluer-eA e avnaldu aFtleud- oBn v MirDusCeKs cwealsls a usssianyge dm uetshinogd aM TteTs ta sfosar yd. eAtenrtmiviinrainl ga ctthiev itiyn hoifb citoimonp oouf nthdes cytopathic effect on cell culture and multiplex RT-PCR. Results: The methanol extract of maca showed low cytotoxicity and inhibited influenza-induced cytopathic effect significantly, while viral load was reduced via inhibition of viral growth in MDCK infected cells. Maca contains potent inhibitors of Flu-A and Flu-B with a selectivity index [cytotoxic concentration 50%/IC50] of 157.4 and 110.5, respectively. Conclusions: In vitro assays demonstrated that maca has antiviral activity not only against Flu-A (like most antiviral agents) but also Flu-B viruses, providing remarkable therapeutic benefits.


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