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Antiviral activity of maca (Lepidium meyenii) against human influenza virus

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Authors
Del Valle Mendoza, Juana
Pumarola, Tomàs
Alzamora Gonzales, Libertad
Del Valle, Luis J.
Issue Date
2014-11-20
Keywords
Influenza virus flu
Antiviral activity
Lepidium meyenii
Maca
xmlui.metadata.dc.contributor.email
jdevall@upc.edu.pe

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Citation
Del Valle Mendoza J, Pumarola T, Gonzales LA, del Valle LJ. Antiviral activity of maca (Lepidium meyenii) against human influenza virus. Asian Pacific Journal of Tropical Medicine. septiembre de 2014;7, Supplement 1:S415-20.
Publisher
Elsevier B.V.
Journal
Asian Pacific Journal of Tropical Medicine
URI
http://hdl.handle.net/10757/335865
DOI
10.1016/S1995-7645(14)60268-6
Additional Links
http://www.sciencedirect.com/science/article/pii/S1995764514602686
Abstract
Objective: To investigate antiviral activity of maca to reduce viral load in kidney (MDCK) cells infected with influenza type A and B viruses (Flu-A and MFalud-inB-, Dreasrpbeyc ctiavneilny)e. Methods: Maca were extracted with methanol (1:2, v/v). The cell viability and toxicity of the eaxgtariancstts Fwluer-eA e avnaldu aFtleud- oBn v MirDusCeKs cwealsls a usssianyge dm uetshinogd aM TteTs ta sfosar yd. eAtenrtmiviinrainl ga ctthiev itiyn hoifb citoimonp oouf nthdes cytopathic effect on cell culture and multiplex RT-PCR. Results: The methanol extract of maca showed low cytotoxicity and inhibited influenza-induced cytopathic effect significantly, while viral load was reduced via inhibition of viral growth in MDCK infected cells. Maca contains potent inhibitors of Flu-A and Flu-B with a selectivity index [cytotoxic concentration 50%/IC50] of 157.4 and 110.5, respectively. Conclusions: In vitro assays demonstrated that maca has antiviral activity not only against Flu-A (like most antiviral agents) but also Flu-B viruses, providing remarkable therapeutic benefits.
Type
info:eu-repo/semantics/article
Rights
info:eu-repo/semantics/openAccess
Language
eng
ISSN
1995-7645
Sponsors
Financial support of this study was provided by AECID grants (PCI: C/033641/10) and AGAUR (MAT2009-11503, MAT2012-36205, 2009SGR-1208). JDVM support was provided by 1st Concurso Incentivo a la Investigación de la Universidad Peruana de Ciencias Aplicadas, Lima, Peru.
ae974a485f413a2113503eed53cd6c53
10.1016/S1995-7645(14)60268-6
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Medicina

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