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dc.contributor.authorWeilg Espejo, Pablo*
dc.contributor.authorOrellana Peralta, Fiorella*
dc.contributor.authorCornejo Pacheres, Hernán*
dc.contributor.authorDel Valle, Luis J.*
dc.contributor.authorCornejo Tapia, Ángela*
dc.contributor.authorBazán Mayra, Jorge*
dc.contributor.authorRuiz, Joaquim*
dc.contributor.authorDel Valle Mendoza, Juana*
dc.date.accessioned2014-03-11T03:08:32Zes_PE
dc.date.available2014-03-11T03:08:32Zes_PE
dc.date.issued2014-03-10es_PE
dc.identifier.citationTrans R Soc Trop Med Hyg first published online April 27, 2014. doi:10.1093/trstmh/tru059eng
dc.identifier.issn1878-3503es_PE
dc.identifier.doi10.1093/trstmh/tru059eng
dc.identifier.urihttp://hdl.handle.net/10757/313901es_PE
dc.descriptionArtículo sustentado el 30 de Enero 2014 para la obtención del título profesional Médico Cirujano en la Escuela de Medicina, Facultad de Ciencias de la Salud. Universidad Peruana de Ciencias Aplicadas - UPC.es_PE
dc.descriptionArtículo publicado el 27 de Abril de 2014 en la Revista Transactions of the Royal Society of Tropical Medicine & Hygiene (Oxford University Press).es_PE
dc.description.abstractBackground: Gastroenteritis by rotavirus is responsible for approximately 810 annual deaths/year in children under 5 years in Peru and emerging rotavirus genotypes have led to concerns regarding cross-protection by the vaccines available. Moreover, there are no reports on the molecular-epidemiology of rotavirus diarrhea in Peru Methodology: A total of 131 stool samples were obtained from children under 5 years old hospitalized from January 2010 to December 2012 in the Hospital Regional de Cajamarca, Peru. ELISA and RT-PCR techniques were performed for rotavirus detection. G and P typing of rotavirus-positive samples were obtained by semi-nested multiplex RT-PCR and sequencing was performed to confirm the PCR results. Results: Of the 117 samples available, 18.80% (22/117) tested positive for rotavirus by ELISA and 35.90% (42/117) by RT-PCR. Among the G-genotype identified, G9 in 35.71% (15/42) and G12 in 33.33% (14/42) were the most prevalent. With the most common combination being G12/P6 in 23.81% (10/42). Conclusions: A high prevalence of the G12/P6 genotype was detected. It is know that this genotype is not covered by the current vaccines available. More in depth studies are needed to know the current rotavirus genotypes presents in Peru.
dc.formatapplication/pdfeng
dc.formatapplication/mswordeng
dc.language.isoenges_PE
dc.publisherOxford University Presseng
dc.relation.urlhttp://www.ncbi.nlm.nih.gov/pubmed/24778205eng
dc.rightsinfo:eu-repo/semantics/openAccesses_PE
dc.sourceUniversidad Peruana de Ciencias Aplicadas (UPC)es_PE
dc.sourceRepositorio Académico - UPCes_PE
dc.subjectViral genotypeseng
dc.subjectEpidemiologyeng
dc.subjectAcute gastroenteritiseng
dc.subjectPerueng
dc.titleDiarrhoea caused by rotavirus in a regional Peruvian hospital: determination of circulating genotypeseng
dc.typeinfo:eu-repo/semantics/articlees_PE
dc.identifier.eissn0035-9203es_PE
dc.description.peer-reviewRevisión por pareses_PE
refterms.dateFOA2018-06-18T23:40:51Z
html.description.abstractBackground: Gastroenteritis by rotavirus is responsible for approximately 810 annual deaths/year in children under 5 years in Peru and emerging rotavirus genotypes have led to concerns regarding cross-protection by the vaccines available. Moreover, there are no reports on the molecular-epidemiology of rotavirus diarrhea in Peru Methodology: A total of 131 stool samples were obtained from children under 5 years old hospitalized from January 2010 to December 2012 in the Hospital Regional de Cajamarca, Peru. ELISA and RT-PCR techniques were performed for rotavirus detection. G and P typing of rotavirus-positive samples were obtained by semi-nested multiplex RT-PCR and sequencing was performed to confirm the PCR results. Results: Of the 117 samples available, 18.80% (22/117) tested positive for rotavirus by ELISA and 35.90% (42/117) by RT-PCR. Among the G-genotype identified, G9 in 35.71% (15/42) and G12 in 33.33% (14/42) were the most prevalent. With the most common combination being G12/P6 in 23.81% (10/42). Conclusions: A high prevalence of the G12/P6 genotype was detected. It is know that this genotype is not covered by the current vaccines available. More in depth studies are needed to know the current rotavirus genotypes presents in Peru.


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