Factors Associated with Anti-Tuberculosis Medication Adverse Effects: A Case-Control Study in Lima, Peru
dc.contributor.author | Chung Delgado, Kocfa | * |
dc.contributor.author | Revilla Montag, Alejandro | * |
dc.contributor.author | Guillen Bravo, Sonia | * |
dc.contributor.author | Velez Segovia, Eduardo | * |
dc.contributor.author | Soria Montoya, Andrea | * |
dc.contributor.author | Nuñez Garbin, Alexandra | * |
dc.contributor.author | Silva-Caso, Wilmer | * |
dc.contributor.author | Bernabe-Ortiz, Antonio | * |
dc.date.accessioned | 2014-03-07T21:32:02Z | |
dc.date.available | 2014-03-07T21:32:02Z | |
dc.date.issued | 2014-03-07 | |
dc.identifier.citation | PLoS ONE 6(11): e27610 | es_PE |
dc.identifier.doi | 10.1371/journal.pone.0027610 | |
dc.identifier.uri | http://hdl.handle.net/10757/313811 | es_PE |
dc.description.abstract | Background: Long-term exposure to anti-tuberculosis medication increases risk of adverse drug reactions and toxicity. The objective of this investigation was to determine factors associated with anti-tuberculosis adverse drug reactions in Lima, Peru, with special emphasis on MDR-TB medication, HIV infection, diabetes, age and tobacco use. Methodology and Results: A case-control study was performed using information from Peruvian TB Programme. A case was defined as having reported an anti-TB adverse drug reaction during 2005–2010 with appropriate notification on clinical records. Controls were defined as not having reported a side effect, receiving anti-TB therapy during the same time that the case had appeared. Crude, and age- and sex-adjusted models were calculated using odds ratios (OR) and 95% confidence intervals (95%CI). A multivariable model was created to look for independent factors associated with side effect from anti-TB therapy. A total of 720 patients (144 cases and 576 controls) were analyzed. In our multivariable model, age, especially those over 40 years (OR = 3.93; 95%CI: 1.65–9.35), overweight/obesity (OR = 2.13; 95%CI: 1.17–3.89), anemia (OR = 2.10; IC95%: 1.13–3.92), MDR-TB medication (OR = 11.1; 95%CI: 6.29–19.6), and smoking (OR = 2.00; 95%CI: 1.03–3.87) were independently associated with adverse drug reactions. Conclusions: Old age, anemia, MDR-TB medication, overweight/obesity status, and smoking history are independent risk factors associated with anti-tuberculosis adverse drug reactions. Patients with these risk factors should be monitored during the anti-TB therapy. A comprehensive clinical history and additional medical exams, including hematocrit and HIV-ELISA, might be useful to identify these patients. | |
dc.format | application/pdf | es_PE |
dc.language.iso | eng | es_PE |
dc.publisher | Public Library of Science (PLoS) | es_PE |
dc.relation.url | http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0027610 | es_PE |
dc.rights | info:eu-repo/semantics/openAccess | es_PE |
dc.source | Universidad Peruana de Ciencias Aplicadas (UPC) | es_PE |
dc.source | Repositorio Académico - UPC | es_PE |
dc.title | Factors Associated with Anti-Tuberculosis Medication Adverse Effects: A Case-Control Study in Lima, Peru | es_PE |
dc.type | info:eu-repo/semantics/article | es_PE |
dc.identifier.eissn | 1932-6203 | |
dc.identifier.orcid | 0000-0003-1962-9434 | eng |
dc.description.peer-review | Revisión por pares | eng |
refterms.dateFOA | 2018-06-19T04:59:32Z | |
html.description.abstract | Background: Long-term exposure to anti-tuberculosis medication increases risk of adverse drug reactions and toxicity. The objective of this investigation was to determine factors associated with anti-tuberculosis adverse drug reactions in Lima, Peru, with special emphasis on MDR-TB medication, HIV infection, diabetes, age and tobacco use. Methodology and Results: A case-control study was performed using information from Peruvian TB Programme. A case was defined as having reported an anti-TB adverse drug reaction during 2005–2010 with appropriate notification on clinical records. Controls were defined as not having reported a side effect, receiving anti-TB therapy during the same time that the case had appeared. Crude, and age- and sex-adjusted models were calculated using odds ratios (OR) and 95% confidence intervals (95%CI). A multivariable model was created to look for independent factors associated with side effect from anti-TB therapy. A total of 720 patients (144 cases and 576 controls) were analyzed. In our multivariable model, age, especially those over 40 years (OR = 3.93; 95%CI: 1.65–9.35), overweight/obesity (OR = 2.13; 95%CI: 1.17–3.89), anemia (OR = 2.10; IC95%: 1.13–3.92), MDR-TB medication (OR = 11.1; 95%CI: 6.29–19.6), and smoking (OR = 2.00; 95%CI: 1.03–3.87) were independently associated with adverse drug reactions. Conclusions: Old age, anemia, MDR-TB medication, overweight/obesity status, and smoking history are independent risk factors associated with anti-tuberculosis adverse drug reactions. Patients with these risk factors should be monitored during the anti-TB therapy. A comprehensive clinical history and additional medical exams, including hematocrit and HIV-ELISA, might be useful to identify these patients. |
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Medicina [970]