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Maria J. Pons, Cláudia Gomes, Ruth Aguilar, Diana Barrios, Miguel Angel Aguilar-Luis, Joaquim Ruiz, Carlota Dobaño, Juana del Valle-Mendoza, Gemma Moncunill
Immunosuppressive and angiogenic cytokine profile associated with Bartonella bacilliformis infection in post-outbreak and endemic areas of Carrion's disease in Peru
www.plosntds.org
www.plosntds.org
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(humoral)Tj
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(and)Tj
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(cellular)Tj
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(immune)Tj
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(responses)Tj
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(are)Tj
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(induced)Tj
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(dur-)Tj
-35.8183 -1.3039 Td
(ing)Tj
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(acute)Tj
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(infection)Tj
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(of)Tj
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(CD)Tj
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([)Tj
0.83 0.64 0.02 0 k
(3)Tj
0 g
(].)Tj
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(seems)Tj
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/F14 1 Tf
1.0261 0 Td
[()]TJ
/F9 1 Tf
(.)Tj
/F14 1 Tf
1.0148 0 Td
[( )4()6(\n)1()4()4()12()12()9()11()-9()18()-4()]TJ
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-32.156 -1.2982 Td
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(3)Tj
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([)Tj
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(3)Tj
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(].)Tj
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(3)Tj
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(].)Tj
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(multiplex)Tj
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(fluorescent)Tj
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(bead-based)Tj
4.7168 0 Td
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1.9956 0 Td
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-34.0041 -1.3039 Td
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[()]TJ
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(.)Tj
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1.0148 0 Td
[( )4()6(\n)1()4()4()12()12()9()11()-9()18()-4()]TJ
/F9 1 Tf
5.023 0 Td
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1.7348 0 Td
(identifying)Tj
4.575 0 Td
(potential)Tj
3.7588 0 Td
(serum)Tj
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(biomarkers)Tj
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(of)Tj
/F14 1 Tf
-36.578 -1.2983 Td
[()]TJ
/F9 1 Tf
(.)Tj
/F14 1 Tf
1.0147 0 Td
[( )4()6(\n)1()4()4()12()12()9()11()-9()18()-4()]TJ
/F9 1 Tf
5.023 0 Td
(infection)Tj
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(in)Tj
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(non-acute)Tj
4.2803 0 Td
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1.7801 0 Td
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(evaluating)Tj
-31.1865 -1.2982 Td
(simultaneously)Tj
6.2418 0 Td
(a)Tj
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(high)Tj
2.0069 0 Td
(number)Tj
3.4185 0 Td
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1.0148 0 Td
(analytes)Tj
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(using)Tj
2.3867 0 Td
(low)Tj
1.6554 0 Td
(sample)Tj
3.0218 0 Td
(volumes,)Tj
3.787 0 Td
(which)Tj
2.6532 0 Td
(facilitates)Tj
3.9572 0 Td
(to)Tj
-34.2196 -1.2983 Td
(extend)Tj
2.9083 0 Td
(the)Tj
1.4683 0 Td
(studies)Tj
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(to)Tj
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(specially)Tj
3.5943 0 Td
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1.6214 0 Td
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Q
q
1 j
1 J
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BT
/F3 1 Tf
1 TL
-0.0033 Tc
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(and)Tj
1.989 0 Td
(methods)Tj
/F0 1 Tf
-5.948 -1.4976 Td
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6.0898 0 Td
(area)Tj
ET
Q
q
1 j
1 J
0 w
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BT
/F9 1 Tf
1 TL
-0.004 Tc
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(A)Tj
0.9014 0 Td
(cross-sectional)Tj
6.1057 0 Td
(survey)Tj
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(was)Tj
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(done)Tj
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(in)Tj
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(5)Tj
0.6973 0 Td
(villages)Tj
3.1181 0 Td
(of)Tj
1.0148 0 Td
(Piura)Tj
2.3754 0 Td
(\(northern)Tj
4.1613 0 Td
(Peru\))Tj
2.4377 0 Td
(on)Tj
1.2756 0 Td
(March)Tj
2.8687 0 Td
(2014)Tj
2.1259 0 Td
([)Tj
0.83 0.64 0.02 0 k
(16)Tj
0 g
(].)Tj
-34.8545 -1.3039 Td
(In)Tj
1.1055 0 Td
(4)Tj
0.6973 0 Td
(of)Tj
1.0148 0 Td
(them)Tj
2.2903 0 Td
(\(Guayaquiles,)Tj
5.6806 0 Td
(Los)Tj
1.6271 0 Td
(Ranchos,)Tj
3.8721 0 Td
(Mayland,)Tj
3.9798 0 Td
(and)Tj
1.7292 0 Td
(Tunal\))Tj
2.931 0 Td
(an)Tj
1.2018 0 Td
(Oroya)Tj
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(fever)Tj
2.1827 0 Td
(outbreak)Tj
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(while)Tj
2.3697 0 Td
(Huancabamba)Tj
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0.8504 0 Td
(a)Tj
0.6519 0 Td
(well-established)Tj
-30.6479 -1.2983 Td
(endemic)Tj
3.651 0 Td
(area)Tj
1.8821 0 Td
(for)Tj
1.389 0 Td
(this)Tj
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([)Tj
0.83 0.64 0.02 0 k
(16)Tj
0 g
()Tj
0.83 0.64 0.02 0 k
(17)Tj
0 g
(].)Tj
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(and)Tj
1.7291 0 Td
(Tunal,)Tj
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-35.0643 -1.2983 Td
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4.3767 0 Td
(diagnosed)Tj
4.286 0 Td
(with)Tj
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(CD)Tj
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(\(by)Tj
1.5193 0 Td
(clinical)Tj
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(symptoms)Tj
4.354 0 Td
(and/or)Tj
2.9424 0 Td
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-35.1097 -1.3039 Td
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2.5114 0 Td
(smear\))Tj
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(during)Tj
2.931 0 Td
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(ciprofloxacin)Tj
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2.931 0 Td
(14)Tj
1.1679 0 Td
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2.0013 0 Td
(following)Tj
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(diagnosis)Tj
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3.8551 0 Td
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1.1792 0 Td
(house-to-house)Tj
6.4176 0 Td
(visits)Tj
2.2337 0 Td
([)Tj
0.83 0.64 0.02 0 k
(16)Tj
0 g
(].)Tj
2.0749 0 Td
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3.3166 0 Td
(and)Tj
1.7291 0 Td
(demo-)Tj
-32.91 -1.3039 Td
(graphical)Tj
3.9061 0 Td
(data)Tj
1.9105 0 Td
(were)Tj
2.126 0 Td
(recorded)Tj
3.7927 0 Td
([)Tj
0.83 0.64 0.02 0 k
(16)Tj
0 g
(].)Tj
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 292.7055 cm
BT
/F0 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(Ethics)Tj
2.9149 0 Td
(statement)Tj
ET
Q
q
1 j
1 J
0 w
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BT
/F9 1 Tf
1 TL
-0.004 Tc
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1.7801 0 Td
(study)Tj
2.3924 0 Td
(was)Tj
1.6951 0 Td
(approved)Tj
3.9742 0 Td
(by)Tj
1.1849 0 Td
(the)Tj
1.4683 0 Td
(Universidad)Tj
5.1363 0 Td
(Peruana)Tj
3.5206 0 Td
(de)Tj
1.1679 0 Td
(Ciencias)Tj
3.6113 0 Td
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4.1159 0 Td
(Ethics)Tj
2.6646 0 Td
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-32.7116 -1.2982 Td
(and)Tj
1.7291 0 Td
(the)Tj
1.4683 0 Td
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3.617 0 Td
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0 Tc
0.8504 0.051 Td
()Tj
-0.004 Tc
0.3288 -0.051 Td
(nic)Tj
1.457 0 Td
(of)Tj
1.0148 0 Td
(Barcelona)Tj
4.1896 0 Td
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2.6702 0 Td
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4.9606 0 Td
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3.3959 0 Td
(informed)Tj
3.9741 0 Td
(consent)Tj
3.3279 0 Td
(was)Tj
-32.9837 -1.3039 Td
(obtained)Tj
3.7303 0 Td
(from)Tj
2.2054 0 Td
(all)Tj
1.1508 0 Td
(adults)Tj
2.6135 0 Td
(and)Tj
1.7292 0 Td
(parents)Tj
3.1748 0 Td
(or)Tj
1.0998 0 Td
(guardians)Tj
4.1556 0 Td
(of)Tj
1.0147 0 Td
(any)Tj
1.6555 0 Td
(child)Tj
2.211 0 Td
(participant)Tj
4.5977 0 Td
(on)Tj
1.2756 0 Td
(their)Tj
2.109 0 Td
(behalf)Tj
-32.7229 -1.2983 Td
(before)Tj
2.7382 0 Td
(recruitment.)Tj
ET
Q
q
1 j
1 J
0 w
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BT
/F0 1 Tf
1 TL
-0.0033 Tc
0 0 Td
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ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 192.359 cm
BT
/F9 1 Tf
1 TL
-0.004 Tc
0 0 Td
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2.8346 0 Td
(samples)Tj
3.3845 0 Td
(from)Tj
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(a)Tj
0.6519 0 Td
(total)Tj
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(144)Tj
1.6441 0 Td
(individuals)Tj
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(out)Tj
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2.1203 0 Td
(randomly)Tj
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(selected.)Tj
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(size)Tj
-35.5689 -1.2982 Td
(was)Tj
1.6951 0 Td
(limited)Tj
3.067 0 Td
(by)Tj
1.1792 0 Td
(the)Tj
1.4627 0 Td
(number)Tj
3.4186 0 Td
(of)Tj
1.0091 0 Td
(tests)Tj
1.9615 0 Td
(that)Tj
1.7745 0 Td
(could)Tj
2.4491 0 Td
(be)Tj
1.1452 0 Td
(performed)Tj
4.4674 0 Td
(in)Tj
1.0318 0 Td
(two)Tj
1.7065 0 Td
(Luminex)Tj
3.8097 0 Td
(kit)Tj
1.2756 0 Td
(plates.)Tj
2.7212 0 Td
(In)Tj
1.1055 0 Td
(a)Tj
0.652 0 Td
(pre-)Tj
-35.9317 -1.3039 Td
(vious)Tj
2.3357 0 Td
(study,)Tj
2.6135 0 Td
(IgG)Tj
1.7405 0 Td
(and)Tj
1.7348 0 Td
(IgM)Tj
1.9162 0 Td
(levels)Tj
2.3754 0 Td
(against)Tj
/F14 1 Tf
3.0274 0 Td
[()]TJ
/F9 1 Tf
(.)Tj
/F14 1 Tf
1.0148 0 Td
[( )4()6(\n)1()4()4()12()12()9()11()-9()18()-4()]TJ
/F9 1 Tf
5.0286 0 Td
(lysate)Tj
2.4378 0 Td
(were)Tj
2.1203 0 Td
(measured)Tj
4.1102 0 Td
(by)Tj
1.1792 0 Td
(ELISA,)Tj
3.0557 0 Td
(and)Tj
/F14 1 Tf
-34.6901 -1.2983 Td
[()]TJ
/F9 1 Tf
(.)Tj
/F14 1 Tf
1.0147 0 Td
[( )4()6(\n)1()4()4()12()12()9()11()-9()18()-4()]TJ
/F9 1 Tf
5.023 0 Td
(was)Tj
1.7008 0 Td
(detected)Tj
3.5659 0 Td
(and)Tj
1.7292 0 Td
(quantified)Tj
4.3086 0 Td
(by)Tj
1.1849 0 Td
(RT-PCR)Tj
3.6453 0 Td
([)Tj
0.83 0.64 0.02 0 k
(16)Tj
0 g
(].)Tj
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 125.9716 cm
BT
/F0 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(Quantification)Tj
6.2598 0 Td
(of)Tj
1.0489 0 Td
(cytokines,)Tj
4.6205 0 Td
(chemokines)Tj
5.4945 0 Td
(and)Tj
1.8614 0 Td
(growth)Tj
3.189 0 Td
(factors)Tj
ET
Q
q
1 j
1 J
0 w
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BT
/F9 1 Tf
1 TL
-0.004 Tc
0 0 Td
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1.7801 0 Td
(Cytokine)Tj
3.8778 0 Td
(Human)Tj
3.3222 0 Td
(Magnetic)Tj
3.9684 0 Td
(30-Plex)Tj
3.2202 0 Td
(Panel)Tj
2.4264 0 Td
(from)Tj
2.211 0 Td
(Life)Tj
1.7348 0 Td
(Technologies)Tj
5.5275 0 Td
(was)Tj
1.7008 0 Td
(used)Tj
2.0636 0 Td
(to)Tj
1.0205 0 Td
(measure)Tj
-32.8533 -1.3039 Td
(the)Tj
1.4683 0 Td
(concentrations)Tj
6.1795 0 Td
(\(pg/mL\))Tj
3.5716 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4683 0 Td
(following)Tj
3.9799 0 Td
(cytokines,)Tj
4.2236 0 Td
(chemokines)Tj
5.0172 0 Td
(and)Tj
1.7348 0 Td
(growth)Tj
3.0728 0 Td
(factors)Tj
2.9026 0 Td
(in)Tj
-34.6334 -1.2982 Td
(serum:)Tj
2.948 0 Td
(epidermal)Tj
4.2519 0 Td
(growth)Tj
3.0727 0 Td
(factor)Tj
2.5399 0 Td
(\(EGF\),)Tj
2.9366 0 Td
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296.7216 179.4623 l
f*
296.7216 168.4624 m
263.3879 168.4624 l
263.3879 168.9625 l
296.7216 168.9625 l
f*
349.5773 179.4623 m
349.5773 168.4624 l
349.0773 168.4624 l
349.0773 179.4623 l
f*
349.0773 168.4624 m
297.2217 168.4624 l
297.2217 168.9625 l
349.0773 168.9625 l
f*
401.468 179.4623 m
401.468 168.4624 l
400.968 168.4624 l
400.968 179.4623 l
f*
400.968 168.4624 m
349.5773 168.4624 l
349.5773 168.9625 l
400.968 168.9625 l
f*
435.3018 179.4623 m
435.3018 168.4624 l
434.8018 168.4624 l
434.8018 179.4623 l
f*
434.8018 168.4624 m
401.468 168.4624 l
401.468 168.9625 l
434.8018 168.9625 l
f*
487.1925 179.4623 m
487.1925 168.4624 l
486.6925 168.4624 l
486.6925 179.4623 l
f*
486.6925 168.4624 m
435.3018 168.4624 l
435.3018 168.9625 l
486.6925 168.9625 l
f*
542.666 179.4623 m
542.666 168.4624 l
542.166 168.4624 l
542.166 179.4623 l
f*
542.166 168.4624 m
487.1925 168.4624 l
487.1925 168.9625 l
542.166 168.9625 l
f*
575.9997 168.4624 m
542.666 168.4624 l
542.666 168.9625 l
575.9997 168.9625 l
f*
121.6494 168.4624 m
121.6494 157.4626 l
121.1494 157.4626 l
121.1494 168.4624 l
f*
121.1494 157.4626 m
36 157.4626 l
36 157.9626 l
121.1494 157.9626 l
f*
159.6064 168.4624 m
159.6064 157.4626 l
159.1064 157.4626 l
159.1064 168.4624 l
f*
159.1064 157.4626 m
121.6494 157.4626 l
121.6494 157.9626 l
159.1064 157.9626 l
f*
211.4972 168.4624 m
211.4972 157.4626 l
210.9971 157.4626 l
210.9971 168.4624 l
f*
210.9971 157.4626 m
159.6064 157.4626 l
159.6064 157.9626 l
210.9971 157.9626 l
f*
263.3879 168.4624 m
263.3879 157.4626 l
262.8879 157.4626 l
262.8879 168.4624 l
f*
262.8879 157.4626 m
211.4972 157.4626 l
211.4972 157.9626 l
262.8879 157.9626 l
f*
297.2217 168.4624 m
297.2217 157.4626 l
296.7216 157.4626 l
296.7216 168.4624 l
f*
296.7216 157.4626 m
263.3879 157.4626 l
263.3879 157.9626 l
296.7216 157.9626 l
f*
349.5773 168.4624 m
349.5773 157.4626 l
349.0773 157.4626 l
349.0773 168.4624 l
f*
349.0773 157.4626 m
297.2217 157.4626 l
297.2217 157.9626 l
349.0773 157.9626 l
f*
401.468 168.4624 m
401.468 157.4626 l
400.968 157.4626 l
400.968 168.4624 l
f*
400.968 157.4626 m
349.5773 157.4626 l
349.5773 157.9626 l
400.968 157.9626 l
f*
435.3018 168.4624 m
435.3018 157.4626 l
434.8018 157.4626 l
434.8018 168.4624 l
f*
434.8018 157.4626 m
401.468 157.4626 l
401.468 157.9626 l
434.8018 157.9626 l
f*
487.1925 168.4624 m
487.1925 157.4626 l
486.6925 157.4626 l
486.6925 168.4624 l
f*
486.6925 157.4626 m
435.3018 157.4626 l
435.3018 157.9626 l
486.6925 157.9626 l
f*
542.666 168.4624 m
542.666 157.4626 l
542.166 157.4626 l
542.166 168.4624 l
f*
542.166 157.4626 m
487.1925 157.4626 l
487.1925 157.9626 l
542.166 157.9626 l
f*
575.9997 157.4626 m
542.666 157.4626 l
542.666 157.9626 l
575.9997 157.9626 l
f*
575.9997 101.2127 m
36 101.2127 l
36 101.7128 l
575.9997 101.7128 l
f*
0.83 0.64 0.02 0 k
36 88.1575 m
185.4425 88.1575 l
h
f*
0 g
7.9999 0 0 7.9999 36 327.7984 cm
BT
/F3 1 Tf
1 TL
-0.005 Tc
0 0 Td
(Table)Tj
2.7992 0 Td
(1.)Tj
1.2614 0 Td
(Epidemiolog)Tj
5.9457 0 Td
(ic)Tj
1.0418 0 Td
(and)Tj
1.9842 0 Td
(demogr)Tj
3.6213 0 Td
(aphic)Tj
2.8063 0 Td
(characte)Tj
4.0394 0 Td
(ristics)Tj
3.1111 0 Td
(of)Tj
1.1551 0 Td
(study)Tj
2.856 0 Td
(particip)Tj
3.5575 0 Td
(ants)Tj
2.2464 0 Td
(stratified)Tj
4.3796 0 Td
(by)Tj
1.3677 0 Td
(RT-PCR,)Tj
4.2308 0 Td
(IgM)Tj
1.9275 0 Td
(and)Tj
1.9772 0 Td
(IgG)Tj
1.878 0 Td
(results.)Tj
ET
Q
q
1 j
1 J
0 w
6.5001 0 0 6.5001 127.0488 314.4755 cm
BT
/F3 1 Tf
1 TL
0 0 Td
(Samples)Tj
6.6721 0 Td
(RT-PCR)Tj
3.9946 0 Td
(+)Tj
4.1167 0 Td
(RT-PCR)Tj
3.9946 0 Td
(-)Tj
3.0178 0 Td
(p-value)Tj
7.2216 0 Td
(IgM+)Tj
8.1375 0 Td
(IgM-)Tj
5.8785 0 Td
(p-value)Tj
7.2129 0 Td
(IgG+)Tj
8.3817 0 Td
(IgG-)Tj
6.1314 0 Td
(p-value)Tj
-64.7507 -1.692 Td
(\(N)Tj
1.2821 0 Td
(=)Tj
0.8111 0 Td
(144\))Tj
3.4277 0 Td
(\(N)Tj
1.2821 0 Td
(=)Tj
0.8111 0 Td
(54,)Tj
1.6136 0 Td
(37.5%\))Tj
4.2824 0 Td
(\(N)Tj
1.2821 0 Td
(=)Tj
0.8111 0 Td
(90,)Tj
1.6135 0 Td
(62.5%\))Tj
9.5155 0 Td
(\(N)Tj
1.2822 0 Td
(=)Tj
0.8111 0 Td
(52,)Tj
1.6135 0 Td
(36.1%\))Tj
4.3086 0 Td
(\(N)Tj
1.2821 0 Td
(=)Tj
0.8111 0 Td
(92,)Tj
1.6136 0 Td
(63.9%\))Tj
9.4806 0 Td
(\(N)Tj
1.2821 0 Td
(=)Tj
0.8111 0 Td
(43,)Tj
1.6136 0 Td
(29.9%\))Tj
4.2824 0 Td
(\(N)Tj
1.2734 0 Td
(=)Tj
0.8198 0 Td
(101,)Tj
2.163 0 Td
(70.1%\))Tj
-74.1964 -1.692 Td
(Sex)Tj
ET
Q
q
1 j
1 J
0 w
4.875 0 0 4.3327 47.5086 295.37 cm
BT
/F0 1 Tf
1 TL
0 0 Td
(a)Tj
ET
Q
q
1 j
1 J
0 w
6.5001 0 0 6.5001 266.7968 292.4787 cm
BT
/F0 1 Tf
1 TL
0 0 Td
(p)Tj
0.7849 0 Td
(=)Tj
0.8111 0 Td
(0.296)Tj
19.6503 0 Td
(p)Tj
0.7762 0 Td
(=)Tj
0.8112 0 Td
(0.288)Tj
20.1299 0 Td
(p)Tj
0.785 0 Td
(=)Tj
0.8111 0 Td
(0.062)Tj
-70.7425 -1.692 Td
(Female)Tj
4.7708 0 Td
(88)Tj
1.3257 0 Td
(\(61.1\))Tj
5.582 0 Td
(30)Tj
1.3344 0 Td
(\(55.6\))Tj
6.646 0 Td
(58)Tj
1.3345 0 Td
(\(64.4\))Tj
11.8964 0 Td
(35)Tj
1.3257 0 Td
(\(67.3\))Tj
6.6897 0 Td
(53)Tj
1.3344 0 Td
(\(57.6\))Tj
11.853 0 Td
(21)Tj
1.3344 0 Td
(\(48.8\))Tj
6.9251 0 Td
(67)Tj
1.3345 0 Td
(\(66.3\))Tj
-62.5266 -1.692 Td
(Male)Tj
3.6108 0 Td
(56)Tj
1.3257 0 Td
(\(38.9\))Tj
5.582 0 Td
(24)Tj
1.3344 0 Td
(\(44.4\))Tj
6.646 0 Td
(32)Tj
1.3345 0 Td
(\(35.5\))Tj
11.8964 0 Td
(17)Tj
1.3257 0 Td
(\(32.7\))Tj
6.6897 0 Td
(39)Tj
1.3344 0 Td
(\(42.4\))Tj
11.853 0 Td
(22)Tj
1.3344 0 Td
(\(51.2\))Tj
6.9251 0 Td
(34)Tj
1.3345 0 Td
(\(33.7\))Tj
/F3 1 Tf
-73.0103 -1.692 Td
(Age)Tj
2.1107 0 Td
(Median)Tj
3.6719 0 Td
(years)Tj
2.8259 0 Td
(\(IQR\))Tj
ET
Q
q
1 j
1 J
0 w
4.875 0 0 4.3327 109.3039 262.3748 cm
BT
/F0 1 Tf
1 TL
0 0 Td
(b,)Tj
1.1396 0 Td
(c)Tj
ET
Q
q
1 j
1 J
0 w
6.5001 0 0 6.5001 125.0645 259.4834 cm
BT
/F0 1 Tf
1 TL
0 0 Td
(40)Tj
1.3344 0 Td
(\(18,)Tj
1.945 0 Td
(52\))Tj
3.0526 0 Td
(36)Tj
1.3344 0 Td
(\(12.25,51\))Tj
7.2304 0 Td
(40)Tj
1.3257 0 Td
(\(27,)Tj
1.945 0 Td
(56\))Tj
3.637 0 Td
(p)Tj
0.785 0 Td
(=)Tj
0.8111 0 Td
(0.114)Tj
3.6108 0 Td
(27.5)Tj
2.163 0 Td
(\(12,)Tj
1.945 0 Td
(44.75\))Tj
4.5964 0 Td
(44)Tj
1.3344 0 Td
(\(31,)Tj
1.945 0 Td
(56.5\))Tj
4.169 0 Td
(p)Tj
/F8 1 Tf
[( )]TJ
/F0 1 Tf
1.3606 0 Td
(0.001)Tj
4.108 0 Td
(40)Tj
1.3344 0 Td
(\(32,)Tj
1.945 0 Td
(51.75\))Tj
5.6692 0 Td
(39)Tj
1.3344 0 Td
(\(13,)Tj
1.945 0 Td
(54\))Tj
3.9074 0 Td
(p)Tj
0.7849 0 Td
(=)Tj
0.8112 0 Td
(0.351)Tj
/F3 1 Tf
-80.0662 -1.692 Td
(Age)Tj
2.1107 0 Td
(group)Tj
3.07 0 Td
(N)Tj
0.9507 0 Td
(\(%\))Tj
ET
Q
q
1 j
1 J
0 w
4.875 0 0 4.3327 85.8897 251.3763 cm
BT
/F0 1 Tf
1 TL
0 0 Td
(a,)Tj
1.1512 0 Td
(c)Tj
ET
Q
q
1 j
1 J
0 w
6.5001 0 0 6.5001 266.4 248.485 cm
BT
/F0 1 Tf
1 TL
0 0 Td
(p)Tj
0.7762 0 Td
(=)Tj
0.8111 0 Td
(0.125)Tj
19.7201 0 Td
(p)Tj
0.7762 0 Td
(=)Tj
0.8111 0 Td
(0.002)Tj
20.13 0 Td
(p)Tj
0.7849 0 Td
(=)Tj
0.8112 0 Td
(0.068)Tj
/F8 1 Tf
-80.0662 -1.692 Td
[( )]TJ
/F0 1 Tf
(10)Tj
14.0944 0 Td
(19)Tj
1.3258 0 Td
(\(13.3\))Tj
5.861 0 Td
(9)Tj
0.7763 0 Td
(\(16.7\))Tj
6.9251 0 Td
(10)Tj
1.3344 0 Td
(\(11.2\))Tj
11.8965 0 Td
(10)Tj
1.3257 0 Td
(\(19.2\))Tj
7.2391 0 Td
(9)Tj
0.785 0 Td
(\(9.9\))Tj
12.4024 0 Td
(1)Tj
0.785 0 Td
(\(2.4\))Tj
6.9251 0 Td
(18)Tj
1.3344 0 Td
(\(17.8\))Tj
-73.0102 -1.692 Td
(11)Tj
1.3344 0 Td
(to)Tj
1.0641 0 Td
(25)Tj
11.6959 0 Td
(22)Tj
1.3258 0 Td
(\(15.4\))Tj
5.5819 0 Td
(13)Tj
1.3345 0 Td
(\(24.1\))Tj
6.9251 0 Td
(9)Tj
0.7849 0 Td
(\(10.1\))Tj
12.1669 0 Td
(14)Tj
1.3257 0 Td
(\(26.9\))Tj
7.2391 0 Td
(8)Tj
0.785 0 Td
(\(8.8\))Tj
12.132 0 Td
(6)Tj
0.7763 0 Td
(\(14.3\))Tj
7.2042 0 Td
(16)Tj
1.3344 0 Td
(\(15.8\))Tj
-73.0102 -1.692 Td
(26)Tj
1.3344 0 Td
(to)Tj
1.0641 0 Td
(55)Tj
11.6959 0 Td
(72)Tj
1.3258 0 Td
(\(50.4\))Tj
5.5819 0 Td
(24)Tj
1.3345 0 Td
(\(44.4\))Tj
6.646 0 Td
(48)Tj
1.3344 0 Td
(\(53.9\))Tj
11.8965 0 Td
(21)Tj
1.3257 0 Td
(\(40.4\))Tj
7.1083 0 Td
(51)Tj
1.3257 0 Td
(\(56\))Tj
11.443 0 Td
(27)Tj
1.3345 0 Td
(\(64.3\))Tj
6.9251 0 Td
(45)Tj
1.3344 0 Td
(\(44.6\))Tj
-73.0102 -1.7008 Td
(56)Tj
1.3344 0 Td
(to70)Tj
13.17 0 Td
(20)Tj
1.3344 0 Td
(\(14\))Tj
5.4424 0 Td
(6)Tj
0.7763 0 Td
(\(11.1\))Tj
6.9251 0 Td
(14)Tj
1.3344 0 Td
(\(15.7\))Tj
12.1669 0 Td
(7)Tj
0.7849 0 Td
(\(13.5\))Tj
6.96 0 Td
(13)Tj
1.3345 0 Td
(\(14.3\))Tj
12.132 0 Td
(6)Tj
0.7763 0 Td
(\(14.3\))Tj
7.2042 0 Td
(14)Tj
1.3344 0 Td
(\(13.9\))Tj
/F8 1 Tf
-73.0102 -1.692 Td
[( !)]TJ
/F0 1 Tf
(71)Tj
14.7835 0 Td
(10)Tj
1.3344 0 Td
(\(7\))Tj
5.4337 0 Td
(2)Tj
0.785 0 Td
(\(3.7\))Tj
7.6141 0 Td
(8)Tj
0.785 0 Td
(\(9\))Tj
12.4372 0 Td
(0)Tj
0.7849 0 Td
(\(0\))Tj
6.6897 0 Td
(10)Tj
1.3257 0 Td
(\(11\))Tj
11.9925 0 Td
(2)Tj
0.785 0 Td
(\(4.8\))Tj
7.4746 0 Td
(8)Tj
0.7849 0 Td
(\(7.9\))Tj
/F3 1 Tf
-73.0102 -1.6921 Td
(Area)Tj
ET
Q
q
1 j
1 J
0 w
4.875 0 0 4.3327 50.3433 185.3291 cm
BT
/F0 1 Tf
1 TL
0 0 Td
(a)Tj
ET
Q
q
1 j
1 J
0 w
6.5001 0 0 6.5001 271.9559 182.4377 cm
BT
/F0 1 Tf
1 TL
0 0 Td
(0.337)Tj
21.2463 0 Td
(0.624)Tj
21.1591 0 Td
(p)Tj
/F8 1 Tf
[( )]TJ
/F0 1 Tf
(0.001)Tj
-78.7056 -1.692 Td
(Post-outbreak)Tj
13.8154 0 Td
(123)Tj
1.8839 0 Td
(\(85.4\))Tj
5.3029 0 Td
(44)Tj
1.3344 0 Td
(\(81.5\))Tj
6.646 0 Td
(79)Tj
1.3345 0 Td
(\(87.8\))Tj
11.8964 0 Td
(43)Tj
1.3258 0 Td
(\(82.7\))Tj
7.1082 0 Td
(80)Tj
1.3258 0 Td
(\(87\))Tj
11.443 0 Td
(29)Tj
1.3344 0 Td
(\(67.4\))Tj
6.9251 0 Td
(94)Tj
1.3345 0 Td
(\(93.1\))Tj
-73.0103 -1.692 Td
(Endemic)Tj
14.0945 0 Td
(21)Tj
1.3257 0 Td
(\(14.6\))Tj
5.582 0 Td
(10)Tj
1.3344 0 Td
(\(18.5\))Tj
6.646 0 Td
(11)Tj
1.3345 0 Td
(\(12.2\))Tj
12.1668 0 Td
(9)Tj
0.785 0 Td
(\(17.3\))Tj
7.3786 0 Td
(12)Tj
1.3258 0 Td
(\(13\))Tj
11.443 0 Td
(14)Tj
1.3344 0 Td
(\(32.6\))Tj
7.4746 0 Td
(7)Tj
0.785 0 Td
(\(6.9\))Tj
ET
Q
q
1 j
1 J
0 w
7.9999 0 0 7.9999 36 141.7322 cm
BT
/F0 1 Tf
1 TL
0 0 Td
(Abbrevia)Tj
3.9118 0 Td
(tions:)Tj
2.6079 0 Td
(IQR,)Tj
2.289 0 Td
(interquar)Tj
3.9118 0 Td
(tile)Tj
1.5024 0 Td
(range.)Tj
ET
Q
q
1 j
1 J
0 w
5.9998 0 0 5.3325 36 133.285 cm
BT
/F0 1 Tf
1 TL
0 0 Td
(a)Tj
ET
Q
q
1 j
1 J
0 w
7.9999 0 0 7.9999 41.159 129.7133 cm
BT
/F0 1 Tf
1 TL
0 0 Td
(P-values)Tj
4.089 0 Td
(were)Tj
2.3811 0 Td
(computed)Tj
4.5921 0 Td
(through)Tj
3.593 0 Td
(two)Tj
1.7787 0 Td
(sided)Tj
2.6008 0 Td
(Fisher's)Tj
3.7064 0 Td
(exact)Tj
2.6079 0 Td
(test.)Tj
ET
Q
q
1 j
1 J
0 w
5.9998 0 0 5.3325 36 121.2661 cm
BT
/F3 1 Tf
1 TL
0 0 Td
(b)Tj
ET
Q
q
1 j
1 J
0 w
7.9999 0 0 7.9999 41.4992 117.6944 cm
BT
/F0 1 Tf
1 TL
0 0 Td
(P-values)Tj
4.096 0 Td
(were)Tj
2.3812 0 Td
(computed)Tj
4.5921 0 Td
(through)Tj
3.593 0 Td
(Wilcoxon)Tj
4.2591 0 Td
(rank-sum)Tj
4.3724 0 Td
(test.)Tj
ET
Q
q
1 j
1 J
0 w
5.9998 0 0 5.3325 36 109.2472 cm
BT
/F3 1 Tf
1 TL
0 0 Td
(c)Tj
ET
Q
q
1 j
1 J
0 w
7.9999 0 0 7.9999 41.159 105.7322 cm
BT
/F0 1 Tf
1 TL
0 0 Td
(Age)Tj
1.9913 0 Td
(is)Tj
0.9496 0 Td
(missing)Tj
3.593 0 Td
(from)Tj
2.2252 0 Td
(one)Tj
1.8779 0 Td
(individual,)Tj
4.6347 0 Td
(who)Tj
2.0481 0 Td
(was)Tj
1.9984 0 Td
(RTPCR)Tj
3.4229 0 Td
(-,)Tj
0.8433 0 Td
(IgM-)Tj
2.2252 0 Td
(and)Tj
1.878 0 Td
(IgG+.)Tj
0.83 0.64 0.02 0 k
/F11 1 Tf
-0.025 Tc
-28.3324 -2.0622 Td
(https://do)Tj
3.5574 0 Td
(i.org/10.1371/j)Tj
5.4425 0 Td
(ournal.pntd.)Tj
4.4646 0 Td
(0005684.t0)Tj
4.2662 0 Td
(01)Tj
ET
Q
q
1 j
1 J
0 w
576 737.1 m
36 737.1 l
36 737.6 l
576 737.6 l
f*
36 741.2598 183.2882 23.6976 re
W* n
q
183.2315 0 0 23.6409 36 741.3165 cm
q
/I0 Do
Q
Q
Q
q
0 0 612 792 re
W* n
1 j
1 J
0 w
7.9999 0 0 7.9999 448.5543 745.7952 cm
BT
/F0 1 Tf
1 TL
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