Lymphocyte-to-monocyte ratio and clinical outcomes in Cholangiocarcinoma: A systematic review and meta-analysis
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Issue Date
2023-02-27Keywords
ColangiocarcinomaLinfocito-monocito
Supervivencia
Metaanálisis
Cholangiocarcinoma
Lymphocyte-monocyte ratio
Survival
Meta-analysis
Metadata
Show full item recordAbstract
Antecedentes y objetivos: La relación de linfocitos a monocitos (LMR) ha demostrado una asociación con los resultados de supervivencia en varias enfermedades oncológicas. Este estudio tuvo como objetivo evaluar la asociación entre LMR y los resultados clínicos para pacientes con colangiocarcinoma. Material y métodos: Se realizó una revisión sistemática y un metaanálisis para evaluar la asociación entre los valores de LMR y la supervivencia general (SG), la supervivencia libre de enfermedad (DFS), la supervivencia libre de recurrencia (RFS) y el tiempo hasta la recurrencia (TTR) en pacientes con colangiocarcinoma. Utilizamos el cociente de riesgos (HR) y el intervalo de confianza (IC) del 95 % como medida del efecto para el metaanálisis del modelo de efectos aleatorios. Se utilizó la escala de Newcastle-Ottawa para la evaluación de la calidad. La prueba de Egger y el gráfico en embudo se desarrollaron para abordar el sesgo de publicación. Resultados: En este estudio se incluyeron un total de 19 estudios (n = 3860). El metaanálisis mostró que los pacientes con colangiocarcinoma con valores bajos de LMR se asociaron con peor SG (HR: 0,82; IC 95 %: 0,71–0,96; I2 = 86 %) y peor TTR (HR: 0,71; IC 95 %: 0,58- 0,86; I2 = 0%). También se evaluaron DFS y RFS; sin embargo, no mostraron asociaciones estadísticamente significativas.Background and aims: Lymphocyte-to-Monocyte Ratio (LMR) has shown an association with survival outcomes in several oncological diseases. This study aimed to evaluate the association between LMR and survival outcomes for cholangiocarcinoma patients. Materials and Methods: A systematic review and meta-analysis was performed to assess the association between LMR and overall survival (OS), disease-free survival (DFS), recurrence-free survival (RFS) and time to recurrence (TTR) in cholangiocarcinoma patients. We used hazard ratios (HRs) and their 95% confidence intervals (CIs) as a measure of effect for the random effect model meta-analysis. The Newcastle-Ottawa Scale was used for quality assessment. The Egger test and funnel plot were developed for approaching publication bias. Results: A total of 19 studies were included in this study (n=3860). The meta-analysis showed that cholangiocarcinoma patients with low values of LMR were associated with worse OS (HR: 0.82; 95% CI: 0.71-0.96; I2=86%) and TTR (HR: 0.71; 95% CI: 0.58-0.86; I2=0%). DFS and RFS also were evaluated; however, they did not show statistically significant associations. Conclusion: Low LMR values were associated with worse OS and TTR.
Type
info:eu-repo/semantics/bachelorThesisRights
info:eu-repo/semantics/openAccessAttribution-NonCommercial-ShareAlike 4.0 International
Language
spaCollections
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- Creative Commons