Prevalence and incidence of diabetic peripheral neuropathy in Latin America and the Caribbean: A systematic review and metaanalysis
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Authors
Yovera-Aldana, MarlonVelasquez-Rimachi, Victor
Huerta-Rosario, Andrely
More-Yupanqui, M. D.
Osores-Flores, Mariela
Espinoza, Ricardo
Gil-Olivares, Fradis
Quispe-Nolazco, Cesar
Quea-Velez, Flor
Moran-Mariños, Christian
Pinedo-Torres, Isabel
Alva-Diaz, Carlos
Pacheco-Barrios, Kevin
Issue Date
2021-05-01
Metadata
Show full item recordPublisher
Public Library of ScienceJournal
PLoS ONEDOI
10.1371/journal.pone.0251642Abstract
Aims The objective of this systematic review and meta-analysis is to estimate the prevalence and incidence of diabetic peripheral neuropathy (DPN) in Latin America and the Caribbean (LAC). Materials and methods We searched MEDLINE, SCOPUS, Web of Science, EMBASE and LILACS databases of published observational studies in LAC up to December 2020. Meta-analyses of proportions were performed using random-effects models using Stata Program 15.1. Heterogeneity was evaluated through sensitivity, subgroup, and meta-regression analyses. Evidence certainty was performed with the GRADE approach. Results Twenty-nine studies from eight countries were included. The estimated prevalence of DPN was 46.5% (95%CI: 38.0-55.0) with a significant heterogeneity (I2 = 98.2%; p<0.01). Only two studies reported incidence, and the pooled effect size was 13.7% (95%CI: 10.6-17.2). We found an increasing trend of cumulative DPN prevalence over time. The main sources of heterogeneity associated with higher prevalence were diagnosis criteria, higher A1c (%), and inadequate sample size. We judge the included evidence as very low certainty. Conclusion The overall prevalence of DPN is high in LAC with significant heterogeneity between and within countries that could be explained by population type and methodological aspects. Significant gaps (e.g., under-representation of most countries, lack of incidence studies, and heterogenous case definition) were identified. Standardized and population-based studies of DPN in LAC are needed.Type
info:eu-repo/semantics/articleRights
info:eu-repo/semantics/openAccessAttribution-NonCommercial-ShareAlike 4.0 International
Language
engEISSN
19326203ae974a485f413a2113503eed53cd6c53
10.1371/journal.pone.0251642
Scopus Count
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