EZSCAN for undiagnosed type 2 diabetes mellitus: A systematic review and meta-analysis
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Autor
Bernabe-Ortiz, AntonioRuiz-Alejos, Andrea
Miranda, J. Jaime
Mathur, Rohini
Perel, Pablo
Smeeth, Liam
Fecha de publicación
2017-10-30Palabras clave
Type 2 diabetesMeta-analysis
Systematic reviews
Database searching
HbA1c
Diabetes mellitus
Glucose tolerance tests
Observational studies
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EZSCAN for undiagnosed type 2 diabetes mellitus: A systematic review and meta-analysis 2017, 12 (10):e0187297 PLOS ONEEditorial
Public Library of Science (PLoS)Journal
PLOS ONEDOI
10.1371/journal.pone.0187297Enlaces adicionales
http://dx.plos.org/10.1371/journal.pone.0187297Resumen
Objectives: The EZSCAN is a non-invasive device that, by evaluating sweat gland function, may detect subjects with type 2 diabetes mellitus (T2DM). The aim of the study was to conduct a systematic review and meta-analysis including studies assessing the performance of the EZSCAN for detecting cases of undiagnosed T2DM. Methodology/Principal findings: We searched for observational studies including diagnostic accuracy and performance results assessing EZSCAN for detecting cases of undiagnosed T2DM. OVID (Medline, Embase, Global Health), CINAHL and SCOPUS databases, plus secondary resources, were searched until March 29, 2017. The following keywords were utilized for the systematic searching: type 2 diabetes mellitus, hyperglycemia, EZSCAN, SUDOSCAN, and sudomotor function. Two investigators extracted the information for meta-analysis and assessed the quality of the data using the Revised Version of the Quality Assessment of Diagnostic Accuracy Studies (QUADAS-2) checklist. Pooled estimates were obtained by fitting the logistic-normal random-effects model without covariates but random intercepts and using the Freeman-Tukey Arcsine Transformation to stabilize variances. Heterogeneity was also assessed using the I2 measure. Four studies (n = 7,720) were included, three of them used oral glucose tolerance test as the gold standard. Using Hierarchical Summary Receiver Operating Characteristic model, summary sensitivity was 72.0% (95%CI: 60.0%– 83.0%), whereas specificity was 56.0% (95%CI: 38.0%– 74.0%). Studies were very heterogeneous (I2 for sensitivity: 79.2% and for specificity: 99.1%) regarding the inclusion criteria and bias was present mainly due to participants selection. Conclusions: The sensitivity of EZSCAN for detecting cases of undiagnosed T2DM seems to be acceptable, but evidence of high heterogeneity and participant selection bias was detected in most of the studies included. More studies are needed to evaluate the performance of the EZSCAN for undiagnosed T2DM screening, especially at the population level.Tipo
info:eu-repo/semantics/articleDerechos
info:eu-repo/semantics/openAccessIdioma
engISSN
1932-6203ae974a485f413a2113503eed53cd6c53
10.1371/journal.pone.0187297
Scopus Count
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