Enfermedad celíaca vs. atrofia villositaria serológicamente negativa: similitudes y diferencias histológicas y en el perfil inmunohistoquímico de linfocitos CD3, CD4, CD8 y CD56
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Authors
Arévalo Suárez, FernandoPortugal, Sabino
Barreda, Carlos
Montes, Pedro
Perez-Narrea, María Teresa
Rodríguez, Omar
Vergara, Greys
Monge, Eduardo
Issue Date
2016-06Keywords
nfermedad celíacaAntígenos CD8
Antígenos CD4
Antígenos CD56
Hiperplasia
Celiac disease
Antigens
CD8
CD56
Hyperplasia
xmlui.metadata.dc.contributor.email
[email protected]
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Celiac disease and negative serology villous atrophy: histological comparison and immunohistochemical study of CD3, CD4, CD8 and CD56 lymphocytesCitation
Arévalo Suárez F, Portugal S, Barreda C, Montes P, Perez-Narrea MT, Rodríguez O, et al. Enfermedad celíaca vs. atrofia villositaria serológicamente negativa: similitudes y diferencias histológicas y en el perfil inmunohistoquímico de linfocitos CD3, CD4, CD8 y CD56. Rev Gastroenterol Peru. 2016;36(2):123-8Journal
Revista de Gastroenterología del Perú (Rev Gastroenterol Peru)Additional Links
http://www.scielo.org.pe/scielo.php?script=sci_arttext&pid=S1022-51292016000200004&lng=es&nrm=iso&tlng=esAbstract
There is a group of enteropathies recently known as seronegative villous atrophy (SNVA), which can simulate celiac disease. Objective: The aim of this study was to describe histological and immunohistochemical differences between a group of Celiac disease and SNVA patients. Material and methods: Microscopy reexamination and Immunohistochemistry study were performed for a group of 15 celiac patients and 19 SNVA patients. Histological features as severe atrophy, crypt hyperplasia, plasma cells number, eosinophils number, neutrophils presence were studied; CD4, CD8, CD3, and CD56 markers were studied through immunohistochemistry. Results: There was a significant difference between the frequency of observation of crypt hyperplasia (p=0.0348) and plasma cells (p=0.0348) in celiac disease patients than SNVA patients. In celiac disease was bigger. The number and distribution of CD 8, CD4 and CD56 lymphocytes was similar in both groups. The percentage of CD3 positive intraepithelial lymphocytes (p=0.0144) was higher in SNVA. Conclusion: Histological and immunohistochemical evaluation shows more similarities than differences. The differences found in this study suggest more humoral immune response in celiac disease than in SNVA.Type
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spaISSN
1022-5129Collections
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