The fecal virome of South and Central American children with diarrhea includes small circular DNA viral genomes of unknown origin.
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Authors
Phan, Tung Giada Costa, Antonio Charlys
Del Valle Mendoza, Juana
Bucardo Rivera, Filemon
Nordgren, Johan
O'Ryan, Miguel
Deng, Xutao
Delwart, Eric
Issue Date
2016-04xmlui.metadata.dc.contributor.email
[email protected]
Metadata
Show full item recordCitation
The fecal virome of South and Central American children with diarrhea includes small circular DNA viral genomes of unknown origin. 2016, 161 (4):959-66 Arch. Virol.Publisher
Springer International PublishingJournal
Archives of virology (Arch Virol.)DOI
10.1007/s00705-016-2756-4PubMed ID
26780893Additional Links
http://www.ncbi.nlm.nih.gov/pubmed/26780893Abstract
Viral metagenomics of feces collected from 58 Peruvian children with unexplained diarrhea revealed several small circular ssDNA genomes. Two genomes related to sequences previously reported in feces from chimpanzees and other mammals and recently named smacoviruses were characterized and then detected by PCR in 1.7 % (1/58) and 19 % (11/58) of diarrheal samples, respectively. Another three genomes from a distinct small circular ssDNA viral group provisionally called pecoviruses encoded Cap and Rep proteins with <35 % identity to those in related genomes reported in human, seal, porcine and dromedary feces. Pecovirus DNA was detected in 15.5 % (9/58), 5.9 % (3/51) and 3 % (3/100) of fecal samples from unexplained diarrhea in Peru, Nicaragua and Chile, respectively. Feces containing these ssDNA genomes also contained known human enteric viral pathogens. The cellular origins of these circular ssDNA viruses, whether human cells, ingested plants, animals or fungal foods, or residents of the gut microbiome, are currently unknown.Type
info:eu-repo/semantics/articleRights
info:eu-repo/semantics/openAccessLanguage
engISSN
1432-8798Sponsors
This study was funded by NHLBI Grant R01 HL105770 to E.L.D and by Sao Paulo Research Foundation (FAPESP) Grant numbers 2014/05211-2 and 2012/03417-7 to A.C.C.ae974a485f413a2113503eed53cd6c53
10.1007/s00705-016-2756-4
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