Refractory Thrombocytopenia Responds to Octreotide Treatment in a Case of Evans Syndrome with Gastric Neuroendocrine Tumor
Average rating
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Star rating
Your vote was cast
Thank you for your feedback
Thank you for your feedback
Authors
Chung Delgado, KocfaRevilla Montag, Alejandro
Guillén Bravo, Sonia
Ríos Díaz, Hugo
Alva Muñoz, José C.
Issue Date
2014-03-12
Metadata
Show full item recordCitation
Case Reports in Hematology Volume 2013, Article ID 391086, 5 pagesPublisher
Hindawi Publishing CorporationDOI
http://dx.doi.org/10.1155/2013/391086Additional Links
http://www.hindawi.com/journals/crihem/2013/391086/Abstract
A 37-year-old woman with history of Evans Syndrome with poor response to high-dose corticoid treatment presented to the emergency department with gastrointestinal and vaginal bleeding. The patient was later diagnosed with severe thrombocytopenia and a stage G1, well-differentiated gastric neuroendocrine tumor, confirmed by a biopsy. A total gastrectomy was performed to eradicate the tumor. After being treated with a total splenectomy for her Evans Syndrome with no clinical or laboratory improvement, she began regular treatment with octreotide on the basis of a possible hepatic metastasis. Days after the initiation of the octreotide, an increase in the platelet count was evidenced by laboratory findings, from 2,000 platelets/mm3 to 109,000 platelets/mm3 . Weeks later, the hepatic metastasis is discarded by a negative octreotide-body scan, and the octreotide treatment was interrupted. Immediately after the drug interruption, a progressive and evident descent in the platelet count was evidenced (4000 platelets/mm3 ). The present case report highlights the possible association between octreotide treatment and a severe thrombocytopenia resistant to conventional treatment.Type
info:eu-repo/semantics/articleRights
info:eu-repo/semantics/openAccessLanguage
engISSN
2090-6560EISSN
2090-6579ae974a485f413a2113503eed53cd6c53
http://dx.doi.org/10.1155/2013/391086
Scopus Count
Collections