Preventive effect of Oenothera rosea on N-methyl-N-nitrosourea- (NMU) induced gastric cancer in rats

2.50
Hdl Handle:
http://hdl.handle.net/10757/622967
Title:
Preventive effect of Oenothera rosea on N-methyl-N-nitrosourea- (NMU) induced gastric cancer in rats
Authors:
Almora Pinedo, Yuan; Arroyo-Acevedo, Jorge Luis; Herrera-Calderon, Oscar; Chumpitaz Cerrate, Victor Manuel; Hañari Quispe, Renán; Tinco Jayo, Johnny Aldo; Franco Quino, Cesar ( https://orcid.org/0000-0003-1773-3019 ) ; Figueroa Salvador, Linder ( https://orcid.org/0000-0002-8425-3069 )
Citation:
Preventive effect of Oenothera rosea on N-methyl-N-nitrosourea- (NMU) induced gastric cancer in rats 2017, Volume 10:327 Clinical and Experimental Gastroenterology
Publisher:
Dove Medical Press Ltd
Journal:
Clinical and Experimental Gastroenterology
Issue Date:
Dec-2017
URI:
http://hdl.handle.net/10757/622967
DOI:
10.2147/CEG.S142515
Additional Links:
https://www.dovepress.com/preventive-effect-of-oenothera-rosea-on-n-methyl-n-nitrosourea--nmu-in-peer-reviewed-article-CEG
Abstract:
Background: Currently, gastric cancer (GC) is considered a public health problem worldwide. Using medicinal plants for the prevention of chronic diseases such as cancer constitutes new alternatives in traditional medicine. Oenothera rosea (OR) could be an option, but it needs to be evaluated. Aim: The main objective of this study was to evaluate the protective effect of OR extract on N-methyl-N-nitrosourea (NMU)-induced GC in rats. Methods: In total, 80 male Holtzman rats were randomized into five groups. Group A received the saline solution (5mL/kg), group B received NMU 500 μg/kg (cancer inductor) by oral administration for 16 weeks, and groups C, D, and E were treated with OR extract (100, 200, and 300 mg/kg, respectively) and NMU in order to evaluate the preventive effect on cancer induced by NMU for 16 weeks. Blood and histological samples of stomachs were collected to determine histopathological, biochemical, and hematological parameters between different experimental groups. Results: Groups C, D, and E presented less histopathological changes such as anaplastic and hyperplastic cells, compared with group B. Hematological and biochemical parameters were recorded, and superoxide dismutase, malondialdehyde, and nitric oxide levels were statistically less than those of NMU group (P<0.05, P<0.01, and P<0.01). Conclusion: Considering the histopathological signs and the antioxidant activity in vivo as well as hematological and biochemical parameters of ethanolic extract of OR, we concluded that its administration in rats has a protective effect on GC, which is induced experimentally. This species could be studied in clinical trials for patients with GC in the future.
Type:
info:eu-repo/semantics/article
Rights:
info:eu-repo/semantics/openAccess
Language:
eng
Keywords:
Anaplasia; Anticancer; Antioxidant; Carcinogenic; Gastroenterology
ISSN:
1178-7023

Full metadata record

DC FieldValue Language
dc.contributor.authorAlmora Pinedo, Yuanes
dc.contributor.authorArroyo-Acevedo, Jorge Luises
dc.contributor.authorHerrera-Calderon, Oscares
dc.contributor.authorChumpitaz Cerrate, Victor Manueles
dc.contributor.authorHañari Quispe, Renánes
dc.contributor.authorTinco Jayo, Johnny Aldoes
dc.contributor.authorFranco Quino, Cesares
dc.contributor.authorFigueroa Salvador, Linderes
dc.date.accessioned2018-03-20T12:22:45Z-
dc.date.available2018-03-20T12:22:45Z-
dc.date.issued2017-12-
dc.identifier.citationPreventive effect of Oenothera rosea on N-methyl-N-nitrosourea- (NMU) induced gastric cancer in rats 2017, Volume 10:327 Clinical and Experimental Gastroenterologyes
dc.identifier.issn1178-7023-
dc.identifier.doi10.2147/CEG.S142515-
dc.identifier.urihttp://hdl.handle.net/10757/622967-
dc.description.abstractBackground: Currently, gastric cancer (GC) is considered a public health problem worldwide. Using medicinal plants for the prevention of chronic diseases such as cancer constitutes new alternatives in traditional medicine. Oenothera rosea (OR) could be an option, but it needs to be evaluated. Aim: The main objective of this study was to evaluate the protective effect of OR extract on N-methyl-N-nitrosourea (NMU)-induced GC in rats. Methods: In total, 80 male Holtzman rats were randomized into five groups. Group A received the saline solution (5mL/kg), group B received NMU 500 μg/kg (cancer inductor) by oral administration for 16 weeks, and groups C, D, and E were treated with OR extract (100, 200, and 300 mg/kg, respectively) and NMU in order to evaluate the preventive effect on cancer induced by NMU for 16 weeks. Blood and histological samples of stomachs were collected to determine histopathological, biochemical, and hematological parameters between different experimental groups. Results: Groups C, D, and E presented less histopathological changes such as anaplastic and hyperplastic cells, compared with group B. Hematological and biochemical parameters were recorded, and superoxide dismutase, malondialdehyde, and nitric oxide levels were statistically less than those of NMU group (P<0.05, P<0.01, and P<0.01). Conclusion: Considering the histopathological signs and the antioxidant activity in vivo as well as hematological and biochemical parameters of ethanolic extract of OR, we concluded that its administration in rats has a protective effect on GC, which is induced experimentally. This species could be studied in clinical trials for patients with GC in the future.es
dc.formatapplication/pdfes
dc.language.isoenges
dc.publisherDove Medical Press Ltdes
dc.relation.urlhttps://www.dovepress.com/preventive-effect-of-oenothera-rosea-on-n-methyl-n-nitrosourea--nmu-in-peer-reviewed-article-CEGes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.sourceUniversidad Peruana de Ciencias Aplicadas (UPC)es_PE
dc.sourceRepositorio Academico - UPCes_PE
dc.subjectAnaplasiaes
dc.subjectAnticanceres
dc.subjectAntioxidantes
dc.subjectCarcinogenices
dc.subjectGastroenterologyes
dc.titlePreventive effect of Oenothera rosea on N-methyl-N-nitrosourea- (NMU) induced gastric cancer in ratses
dc.typeinfo:eu-repo/semantics/articlees
dc.identifier.journalClinical and Experimental Gastroenterologyes
dc.description.peerreviewRevisión por pareses_PE
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