Obesity-related insulin resistance in adolescents: a systematic review and meta-analysis of observational studies

2.50
Hdl Handle:
http://hdl.handle.net/10757/622281
Title:
Obesity-related insulin resistance in adolescents: a systematic review and meta-analysis of observational studies
Authors:
Thota, P.; Perez-Lopez, F. R.; Benites-Zapata, V. A.; Pasupuleti, V.; Hernandez, Adrian V. ( 0000-0002-9999-4003 )
Citation:
Obesity-related insulin resistance in adolescents: a systematic review and meta-analysis of observational studies 2017, 33 (3):179 Gynecological Endocrinology
Publisher:
Taylor and Francis Ltd
Journal:
Gynecological Endocrinology
Issue Date:
19-Jan-2017
URI:
http://hdl.handle.net/10757/622281
DOI:
10.1080/09513590.2016.1273897
Additional Links:
https://www.tandfonline.com/doi/full/10.1080/09513590.2016.1273897
Abstract:
Insulin resistance is common among obese adolescents; however, the extent of this problem is not clear. We conducted a systematic review of PubMed-Medline, CINAHL, The Web of Science, EMBASE and Scopus for observational studies evaluating components defining insulin resistance (insulin, C-peptide and homeostatic model assessment-insulin resistance [HOMA-IR]) in obese adolescents (12–18 years) versus non-obese adolescents. Our systematic review and meta-analysis followed the PRISMA guidelines. Data were combined using a random-effects model and summary statistics were calculated using the mean differences (MDs). 31 studies were included (n = 8655). In 26 studies, fasting insulin levels were higher in obese adolescents when compared to non-obese adolescents (MD = 64.11 pmol/L, 95%CI 49.48–78.75, p < 0.00001). In three studies, fasting C-peptide levels were higher in obese adolescents when compared to non-obese adolescents (MD = 0.29 nmol/L, 95%CI 0.22–0.36, p < 0.00001). In 24 studies, HOMA-IR values were higher in obese adolescents when compared to non-obese adolescents (MD = 2.22, 95%CI 1.78–2.67, p < 0.00001). Heterogeneity of effects among studies was moderate to high. Subgroup analyses showed similar results to the main analyses. Circulating insulin and C-peptide levels and HOMA-IR values were significantly higher in obese adolescents compared to those non-obese.
Type:
info:eu-repo/semantics/article
Rights:
info:eu-repo/semantics/restrictedAccess
Language:
eng
Description:
El texto completo de este trabajo no está disponible en el Repositorio Académico UPC por restricciones de la casa editorial donde ha sido publicado.
Keywords:
Adolescence; C-peptide; HOMA-IR; Homeostatic model assessment-insulin resistance; Insulin; Insulin resistance; Obesity
ISSN:
0951-3590; 1473-0766
Email:
adrianhernandezdiaz@gmail.com

Full metadata record

DC FieldValue Language
dc.contributor.authorThota, P.es
dc.contributor.authorPerez-Lopez, F. R.es
dc.contributor.authorBenites-Zapata, V. A.es
dc.contributor.authorPasupuleti, V.es
dc.contributor.authorHernandez, Adrian V.es
dc.date.accessioned2017-10-22T18:11:42Z-
dc.date.available2017-10-22T18:11:42Z-
dc.date.issued2017-01-19-
dc.identifier.citationObesity-related insulin resistance in adolescents: a systematic review and meta-analysis of observational studies 2017, 33 (3):179 Gynecological Endocrinologyes
dc.identifier.issn0951-3590-
dc.identifier.issn1473-0766-
dc.identifier.doi10.1080/09513590.2016.1273897-
dc.identifier.urihttp://hdl.handle.net/10757/622281-
dc.descriptionEl texto completo de este trabajo no está disponible en el Repositorio Académico UPC por restricciones de la casa editorial donde ha sido publicado.es_PE
dc.description.abstractInsulin resistance is common among obese adolescents; however, the extent of this problem is not clear. We conducted a systematic review of PubMed-Medline, CINAHL, The Web of Science, EMBASE and Scopus for observational studies evaluating components defining insulin resistance (insulin, C-peptide and homeostatic model assessment-insulin resistance [HOMA-IR]) in obese adolescents (12–18 years) versus non-obese adolescents. Our systematic review and meta-analysis followed the PRISMA guidelines. Data were combined using a random-effects model and summary statistics were calculated using the mean differences (MDs). 31 studies were included (n = 8655). In 26 studies, fasting insulin levels were higher in obese adolescents when compared to non-obese adolescents (MD = 64.11 pmol/L, 95%CI 49.48–78.75, p < 0.00001). In three studies, fasting C-peptide levels were higher in obese adolescents when compared to non-obese adolescents (MD = 0.29 nmol/L, 95%CI 0.22–0.36, p < 0.00001). In 24 studies, HOMA-IR values were higher in obese adolescents when compared to non-obese adolescents (MD = 2.22, 95%CI 1.78–2.67, p < 0.00001). Heterogeneity of effects among studies was moderate to high. Subgroup analyses showed similar results to the main analyses. Circulating insulin and C-peptide levels and HOMA-IR values were significantly higher in obese adolescents compared to those non-obese.es
dc.formatapplication/pdfes
dc.language.isoenges
dc.publisherTaylor and Francis Ltdes
dc.relation.urlhttps://www.tandfonline.com/doi/full/10.1080/09513590.2016.1273897es
dc.rightsinfo:eu-repo/semantics/restrictedAccesses
dc.subjectAdolescencees
dc.subjectC-peptidees
dc.subjectHOMA-IRes
dc.subjectHomeostatic model assessment-insulin resistancees
dc.subjectInsulines
dc.subjectInsulin resistancees
dc.subjectObesityes
dc.titleObesity-related insulin resistance in adolescents: a systematic review and meta-analysis of observational studieses
dc.typeinfo:eu-repo/semantics/articlees
dc.identifier.journalGynecological Endocrinologyes
dc.contributor.institutionSchool of Medicine, Case Western Reserve University, Cleveland, OH, USA,-
dc.contributor.institutionDepartment of Obstetrics and Gynecology, University of Zaragoza Faculty of Medicine and Lozano Blesa University Hospital, Domingo Miral s/n, Zaragoza, Spain,-
dc.contributor.institutionCenter for Public Health Research, Research Institute, Faculty of Medicine, University of San Martin de Porres, Lima, Peru,-
dc.contributor.institutionSchool of Medicine, Case Western Reserve University, Cleveland, OH, USA,-
dc.contributor.institutionSchool of Medicine, Universidad Peruana de Ciencias Aplicadas (UPC), Lima, Peru, and-
dc.description.peerreviewRevisión por pareses_PE
dc.contributor.emailadrianhernandezdiaz@gmail.comes_PE
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