Human papillomavirus vaccine efficacy in the prevention of anogenital warts: systematic review and meta-analysis.

5.00
Hdl Handle:
http://hdl.handle.net/10757/622240
Title:
Human papillomavirus vaccine efficacy in the prevention of anogenital warts: systematic review and meta-analysis.
Authors:
Tejada, Romina A; Vargas, Kris G; Benites-Zapata, Vicente; Mezones-Holguín, Edward ( 0000-0001-7168-8613 ) ; Bolaños-Díaz, Rafael; Hernandez, Adrian V. ( 0000-0002-9999-4003 )
Citation:
Human papillomavirus vaccine efficacy in the prevention of anogenital warts: systematic review and meta-analysis., 59 (1):84-94 Salud Publica Mex
Publisher:
Instituto Nacional de Salud Pública
Journal:
Salud publica de Mexico
Issue Date:
Feb-2017
URI:
http://hdl.handle.net/10757/622240
DOI:
10.21149/7824
PubMed ID:
28423114
Abstract:
Objective: To review evidence on the efficacy of HPV vaccines in the prevention of non-cancer lesions (anogenital warts [AGW], recurrent laryngeal papillomatosis and oral papillomatosis). Materials and methods: We conducted a systematic review of randomized trials. We performed random effect models and effects were reported as relative risks (RR) and their confidence intervals (95%CI) following both intention to treat (ITT) and per protocol (PP) analyses. Results: We included six studies (n=27 078). One study was rated as high risk of bias. One study could not be included in the meta-analysis because it provided combined results. We found that quadrivalent vaccine reduced the risk of AGW by 62% (RR: 0.38, 95%CI:0.32-0.45, I2:0%) in the ITT analysis and by 95% (RR: 0.05, 95%CI:0.01-0.25, I2:66%) in the PP analysis. Subgroup analyses of studies in women or with low-risk of bias provided similar results. Conclusion: HPV quadrivalent vaccine is efficacious in preventing AGW in men and women.
Abstract:
HPV quadrivalent vaccine is efficacious in preventing AGW in men and women.
Type:
info:eu-repo/semantics/article
Rights:
info:eu-repo/semantics/openAccess
Language:
spa
Keywords:
Papillomavirus vaccines; Condyloma; Papillomatosis; Meta-analysis
ISSN:
1606-7916
Email:
rtejada@ins.gob.pe

Full metadata record

DC FieldValue Language
dc.contributor.authorTejada, Romina Aes
dc.contributor.authorVargas, Kris Ges
dc.contributor.authorBenites-Zapata, Vicentees
dc.contributor.authorMezones-Holguín, Edwardes
dc.contributor.authorBolaños-Díaz, Rafaeles
dc.contributor.authorHernandez, Adrian V.es
dc.date.accessioned2017-10-16T20:34:46Z-
dc.date.available2017-10-16T20:34:46Z-
dc.date.issued2017-02-
dc.identifier.citationHuman papillomavirus vaccine efficacy in the prevention of anogenital warts: systematic review and meta-analysis., 59 (1):84-94 Salud Publica Mexes
dc.identifier.issn1606-7916-
dc.identifier.pmid28423114-
dc.identifier.doi10.21149/7824-
dc.identifier.urihttp://hdl.handle.net/10757/622240-
dc.description.abstractObjective: To review evidence on the efficacy of HPV vaccines in the prevention of non-cancer lesions (anogenital warts [AGW], recurrent laryngeal papillomatosis and oral papillomatosis). Materials and methods: We conducted a systematic review of randomized trials. We performed random effect models and effects were reported as relative risks (RR) and their confidence intervals (95%CI) following both intention to treat (ITT) and per protocol (PP) analyses. Results: We included six studies (n=27 078). One study was rated as high risk of bias. One study could not be included in the meta-analysis because it provided combined results. We found that quadrivalent vaccine reduced the risk of AGW by 62% (RR: 0.38, 95%CI:0.32-0.45, I2:0%) in the ITT analysis and by 95% (RR: 0.05, 95%CI:0.01-0.25, I2:66%) in the PP analysis. Subgroup analyses of studies in women or with low-risk of bias provided similar results. Conclusion: HPV quadrivalent vaccine is efficacious in preventing AGW in men and women.es
dc.description.abstractHPV quadrivalent vaccine is efficacious in preventing AGW in men and women.es
dc.formatapplication/pdfes
dc.language.isospaes
dc.publisherInstituto Nacional de Salud Públicaes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectPapillomavirus vaccineses
dc.subjectCondylomaes
dc.subjectPapillomatosises
dc.subjectMeta-analysises
dc.titleHuman papillomavirus vaccine efficacy in the prevention of anogenital warts: systematic review and meta-analysis.es
dc.typeinfo:eu-repo/semantics/articlees
dc.identifier.journalSalud publica de Mexicoes
dc.description.peerreviewRevisión por pareses_PE
dc.contributor.emailrtejada@ins.gob.pees_PE

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