Incidencia y factores asociados de Helicobacter pylori en la población infantil del departamento de Cajamarca - Perú’

2.50
Hdl Handle:
http://hdl.handle.net/10757/621826
Title:
Incidencia y factores asociados de Helicobacter pylori en la población infantil del departamento de Cajamarca - Perú’
Authors:
Calderón Rivera, Andrea Ximena; Espinal Reyes, Maria De Fátima; Palacios Cuervo, Fernando André
Advisors:
Del Valle Mendoza, Juana Mercedes ( 0000-0002-6011-5040 ) ; Soto, Alonso
Publisher:
Universidad Peruana de Ciencias Aplicadas (UPC)
Issue Date:
12-Feb-2016
URI:
http://hdl.handle.net/10757/621826
Abstract:
Background: The prevalence of H. pylori is greater than 50% in low development countries. In children, infection with H. pylori produces effects such as low height, impairment in growth especially in pubertal age. Polymerase Chain Reaction has a high sensitivity and specificity of 89.6% and 100% respectively, compared to other invasive methods. The objective of this study is to determine the frequency of patients with presence of H. pylori in asymptomatic children in a rural community in the north of Peru, using PCR technique in stool samples. Methods: A cross-sectional study with a convenience sampling was performed, resulting in 147 children aged between 6-14 years old of the district of San Pablo in Cajamarca, Peru. Using stool samples H. pylori DNA was obtained, then PCR amplification was done, and sequencing those with positive results, in an agreement with Macrogen, Seoul - Korea. Results: It was found a frequency of H. pylori positive cases of 21.1% with a CI 95% of 14.8 to 28.6. It was found a frequency (p=0.01) of positive for H. pylori among males (29% IC95: 19.1- 40.5) compared to women (12.7%; IC95: 6.0-22.7). There was no statistically significant differences between those positive and negative patients with H. pylori compared to age (p = 0.57), presence of overweight (p = 0.09), or excreta disposal (p = 0.71). It was not found significance difference among other variables. Conclusion: Our study found a high frequency of H. pylori determined by a molecular test with high sensitivity and specificity, demonstrating the feasibility of its implementation in rural communities. It can be considered as a tool for surveillance in areas of high prevalence of H. pylori infection.
Type:
info:eu-repo/semantics/bachelorThesis
Rights:
info:eu-repo/semantics/openAccess
Language:
eng
Keywords:
Helicobacter pylori; PCR; Gastric disease; Duodenal peptide ulcer disease

Full metadata record

DC FieldValue Language
dc.contributor.advisorDel Valle Mendoza, Juana Mercedeses
dc.contributor.advisorSoto, Alonsoes
dc.contributor.authorCalderón Rivera, Andrea Ximenaes
dc.contributor.authorEspinal Reyes, Maria De Fátimaes
dc.contributor.authorPalacios Cuervo, Fernando Andrées
dc.date.accessioned2017-08-21T22:48:47Z-
dc.date.available2017-08-21T22:48:47Z-
dc.date.issued2016-02-12-
dc.identifier.urihttp://hdl.handle.net/10757/621826-
dc.description.abstractBackground: The prevalence of H. pylori is greater than 50% in low development countries. In children, infection with H. pylori produces effects such as low height, impairment in growth especially in pubertal age. Polymerase Chain Reaction has a high sensitivity and specificity of 89.6% and 100% respectively, compared to other invasive methods. The objective of this study is to determine the frequency of patients with presence of H. pylori in asymptomatic children in a rural community in the north of Peru, using PCR technique in stool samples. Methods: A cross-sectional study with a convenience sampling was performed, resulting in 147 children aged between 6-14 years old of the district of San Pablo in Cajamarca, Peru. Using stool samples H. pylori DNA was obtained, then PCR amplification was done, and sequencing those with positive results, in an agreement with Macrogen, Seoul - Korea. Results: It was found a frequency of H. pylori positive cases of 21.1% with a CI 95% of 14.8 to 28.6. It was found a frequency (p=0.01) of positive for H. pylori among males (29% IC95: 19.1- 40.5) compared to women (12.7%; IC95: 6.0-22.7). There was no statistically significant differences between those positive and negative patients with H. pylori compared to age (p = 0.57), presence of overweight (p = 0.09), or excreta disposal (p = 0.71). It was not found significance difference among other variables. Conclusion: Our study found a high frequency of H. pylori determined by a molecular test with high sensitivity and specificity, demonstrating the feasibility of its implementation in rural communities. It can be considered as a tool for surveillance in areas of high prevalence of H. pylori infection.es
dc.description.uriTesises_PE
dc.formatapplication/pdfes
dc.formatapplication/mswordes
dc.language.isoenges
dc.publisherUniversidad Peruana de Ciencias Aplicadas (UPC)es
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.sourceUniversidad Peruana de Ciencias Aplicadas (UPC)es_PE
dc.sourceRepositorio Académico - UPCes_PE
dc.subjectHelicobacter pylories
dc.subjectPCRes
dc.subjectGastric diseasees
dc.subjectDuodenal peptide ulcer diseasees
dc.titleIncidencia y factores asociados de Helicobacter pylori en la población infantil del departamento de Cajamarca - Perú’es
dc.typeinfo:eu-repo/semantics/bachelorThesises
thesis.degree.grantorUniversidad Peruana de Ciencias Aplicadas (UPC). Facultad de Ciencias de la Saludes_PE
thesis.degree.levelLicenciaturaes_PE
thesis.degree.disciplineMedicinaes_PE
thesis.degree.nameMédico cirujanoes_PE
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