Insulin resistance and endometrial cancer risk: A systematic review and meta-analysis

2.50
Hdl Handle:
http://hdl.handle.net/10757/621216
Title:
Insulin resistance and endometrial cancer risk: A systematic review and meta-analysis
Authors:
Hernandez, Adrian V. ( 0000-0002-9999-4003 ) ; Pasupuleti, Vinay; Benites Zapata, Vicente A. ( 0000-0002-9158-1108 ) ; Thota, Priyaleela; Deshpande, Abhishek ( 0000-0001-5522-2995 ) ; Perez Lopez, Faustino R.
Citation:
: Hernandez AV, et al., Insulin resistance and endometrial cancer risk: A systematic review and meta-analysis, European Journal of Cancer (2015), http://dx.doi.org/10.1016/j.ejca.2015.08.031
Publisher:
Elsevier B.V.
Journal:
European Journal of Cancer
Issue Date:
Dec-2015
URI:
http://hdl.handle.net/10757/621216
DOI:
10.1016/j.ejca.2015.08.031
Additional Links:
http://linkinghub.elsevier.com/retrieve/pii/S0959804915008515
Abstract:
Abstract Aim: It has been suggested that chronic hyperinsulinemia from insulin resistance is involved in the etiology of endometrial cancer (EC). We performed a systematic review and meta-analysis to assess whether insulin resistance is associated with the risk of EC. Methods: We searched PubMed-Medline, Embase, Scopus, and Web of Science for articles published from database inception through 30th September 2014. We included all observational studies evaluating components defining insulin resistance in women with and without EC. Quality of the included studies was assessed by NewcastleeOttawa scale. Randomeffects models and inverse variance method were used to meta-analyze the association between insulin resistance components and EC. Results: Twenty-five studies satisfied our inclusion criteria. Fasting insulin levels (13 studies, n Z 4088) were higher in women with EC (mean difference [MD] 33.94 pmol/L, 95% confi- dence interval [CI] 15.04e52.85, p Z 0.0004). No differences were seen in postmenopausal versus pre- and postmenopausal subgroup analysis. Similarly, non-fasting/fasting C-peptide levels (five studies, n Z 1938) were also higher in women with EC (MD 0.14 nmol/L, 95% CI 0.08e0.21, p < 0.00001). Homeostatic model assessment - insulin resistance (HOMA-IR) values (six studies, n Z 1859) in EC patients were significantly higher than in women without EC (MD 1.13, 95% CI 0.20e2.06, p Z 0.02). There was moderate-to-high heterogeneity among the included studies. Conclusion: Currently available epidemiologic evidence is suggestive of significantly higher risk of EC in women with high fasting insulin, non-fasting/fasting C-peptide and HOMAIR values.
Type:
info:eu-repo/semantics/article
Rights:
info:eu-repo/semantics/openAccess
Language:
eng
Keywords:
Insulin resistance; Endometrial cancer; Meta analysis
ISSN:
09598049
Email:
adrianhernandezdiaz@gmail.com

Full metadata record

DC FieldValue Language
dc.contributor.authorHernandez, Adrian V.es
dc.contributor.authorPasupuleti, Vinayes
dc.contributor.authorBenites Zapata, Vicente A.es
dc.contributor.authorThota, Priyaleelaes
dc.contributor.authorDeshpande, Abhishekes
dc.contributor.authorPerez Lopez, Faustino R.es
dc.date.accessioned2017-03-30T14:50:59Z-
dc.date.available2017-03-30T14:50:59Z-
dc.date.issued2015-12-
dc.identifier.citation: Hernandez AV, et al., Insulin resistance and endometrial cancer risk: A systematic review and meta-analysis, European Journal of Cancer (2015), http://dx.doi.org/10.1016/j.ejca.2015.08.031es
dc.identifier.issn09598049-
dc.identifier.doi10.1016/j.ejca.2015.08.031-
dc.identifier.urihttp://hdl.handle.net/10757/621216-
dc.description.abstractAbstract Aim: It has been suggested that chronic hyperinsulinemia from insulin resistance is involved in the etiology of endometrial cancer (EC). We performed a systematic review and meta-analysis to assess whether insulin resistance is associated with the risk of EC. Methods: We searched PubMed-Medline, Embase, Scopus, and Web of Science for articles published from database inception through 30th September 2014. We included all observational studies evaluating components defining insulin resistance in women with and without EC. Quality of the included studies was assessed by NewcastleeOttawa scale. Randomeffects models and inverse variance method were used to meta-analyze the association between insulin resistance components and EC. Results: Twenty-five studies satisfied our inclusion criteria. Fasting insulin levels (13 studies, n Z 4088) were higher in women with EC (mean difference [MD] 33.94 pmol/L, 95% confi- dence interval [CI] 15.04e52.85, p Z 0.0004). No differences were seen in postmenopausal versus pre- and postmenopausal subgroup analysis. Similarly, non-fasting/fasting C-peptide levels (five studies, n Z 1938) were also higher in women with EC (MD 0.14 nmol/L, 95% CI 0.08e0.21, p < 0.00001). Homeostatic model assessment - insulin resistance (HOMA-IR) values (six studies, n Z 1859) in EC patients were significantly higher than in women without EC (MD 1.13, 95% CI 0.20e2.06, p Z 0.02). There was moderate-to-high heterogeneity among the included studies. Conclusion: Currently available epidemiologic evidence is suggestive of significantly higher risk of EC in women with high fasting insulin, non-fasting/fasting C-peptide and HOMAIR values.es
dc.formatapplication/pdfes
dc.language.isoenges
dc.publisherElsevier B.V.es
dc.relation.urlhttp://linkinghub.elsevier.com/retrieve/pii/S0959804915008515es
dc.rightsinfo:eu-repo/semantics/openAccesses_PE
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.sourceUniversidad Peruana de Ciencias Aplicadas (UPC)es_PE
dc.sourceRepositorio Académico - UPCes_PE
dc.subjectInsulin resistancees
dc.subjectEndometrial canceres
dc.subjectMeta analysises
dc.titleInsulin resistance and endometrial cancer risk: A systematic review and meta-analysises
dc.typeinfo:eu-repo/semantics/articlees_PE
dc.identifier.journalEuropean Journal of Canceres
dc.description.peerreviewRevisión por pareses_PE
dc.contributor.emailadrianhernandezdiaz@gmail.comes_PE
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